Articles

Multiomics reveals that sexual differentiation in human malaria parasites, which is essential for transmission, is regulated by competition between phospholipid metabolism and histone methylation.

A conjugative plasmid isolated from Thermococcus enables interspecies transfer across Archaea, whether naturally competent or not, and at temperatures up to 100 °C.

Structural and biochemical analyses show how one archaeon links both sulfur reduction and methane production.

Oil-rich deep-sea sediments are used to culture syntrophic communities of archaea and bacteria that pair petroleum alkane oxidation to sulfide generation.

The plant commensal Bacillus velezensis SQR9 uses its type VII secretion system to deliver effector protein YukE to plant roots, which causes iron leakage and promotes its colonization on roots.

Genomic and phenotypic analyses of 272 infant-associated Clostridium perfringens isolates suggest that pfoA is an important toxin gene in C. perfringens linked with preterm infant intestinal diseases.

RNAi and single-cell RNA-seq characterize the mechanism of endosymbiosis between coral and dinoflagellates.

Metadegradome sequencing maps 5′P mRNA decay intermediates in complex samples and 96 isolated bacterial species, to identify codon- and gene-level ribosome stalling responses to stress and drug treatment.

A suite of human monoclonal antibodies block infection by all human ACE2 binding sarbecoviruses, including severe acute respiratory syndrome coronavirus 2 variants, at subnanomolar concentrations in cell culture and protect mice against severe acute respiratory syndrome coronavirus 2 infection.

Centenarians have a diverse population of gut bacteriophages, a subset of which encode sulfate metabolism genes and may promote healthy aging.

Comparing norovirus infection in neonate and adult mice suggests age-dependent differences in passive viral uptake, cellular tropism, interferon regulation and viral dissemination.

Personal information such as genetic sex, ancestry and clinically relevant genetic variants can be recovered from human reads present in faecal metagenomic sequencing data.

Analyses of metagenome-resolved genomes from humans and primate species reveal significant co-diversification of bacterial gut symbionts, which are becoming extinct from human populations.

Chloroquine resistance in Plasmodium falciparum is characterized using population genomics, genetic crosses and gene editing.

Characterization of the myotis bat morbillivirus shows that infection in human cells is restricted by innate immune responses in vitro and cross-neutralization by sera from measles, mumps and rubella vaccinees.

An artificial intelligence system called BacterAI uses laboratory robots to learn the logic of microbial metabolism. BacterAI plans experiments autonomously and does not require any prior knowledge.

The microbiota associated with the rice plant panicle can protect against fungal disease via modulating host leucine production and induction of apoptosis-like cell death in the pathogen.

Inhibition of fatty acid biosynthesis re-sensitizes colistin-resistant clinically relevant bacteria in vivo by inducing stress responses and altering membrane composition.

The cryogenic electron microscopy structure of the Pseudomonas aeruginosa cell division complex and antibiotic drug target, FtsWIQBL, suggests a possible activation mechanism.

Sampling beneath the Ross Ice Shelf in Antarctica coupled to global sequencing datasets reveals an important but overlooked contributor to deep ocean carbon and sulfur cycles.