Articles

  • Article |

    Bacillus subtilis cells are able to sense self-produced autoinducers, which gives rise to stronger quorum-sensing-mediated responses, in a process that can influence the generation of persisters during antibiotic treatment.

    • Tasneem Bareia
    • , Shaul Pollak
    •  & Avigdor Eldar
  • Article |

    Comparative genomics and high-resolution mass spectrometry reveal the biosynthetic gene clusters, and vast chemical diversity of natural products that they encode, in Photorhabdus and Xenorhabdus, bacteria that interact with hosts as symbionts and entomopathogens.

    • Nicholas J. Tobias
    • , Hendrik Wolff
    • , Bardya Djahanschiri
    • , Florian Grundmann
    • , Max Kronenwerth
    • , Yi-Ming Shi
    • , Svenja Simonyi
    • , Peter Grün
    • , David Shapiro-Ilan
    • , Sacha J. Pidot
    • , Timothy P. Stinear
    • , Ingo Ebersberger
    •  & Helge B. Bode
  • Article |

    Under nutritional limitation, modification of the Lactobacillus plantarum cell wall by d-alanylation of teichoic acids is important for host intestinal peptidase expression and consequently growth of the Drosophila host, providing further insights into host–commensal interactions.

    • Renata C. Matos
    • , Martin Schwarzer
    • , Hugo Gervais
    • , Pascal Courtin
    • , Pauline Joncour
    • , Benjamin Gillet
    • , Dali Ma
    • , Anne-Laure Bulteau
    • , Maria Elena Martino
    • , Sandrine Hughes
    • , Marie-Pierre Chapot-Chartier
    •  & François Leulier
  • Article |

    An atomic model for a type 2 secretion system pseudopilus from Klebsiella oxytoca reveals a comprehensive network of inter-subunit contacts while mutational and functional analyses highlight the role of calcium in PulG folding and stability.

    • Aracelys López-Castilla
    • , Jenny-Lee Thomassin
    • , Benjamin Bardiaux
    • , Weili Zheng
    • , Mangayarkarasi Nivaskumar
    • , Xiong Yu
    • , Michael Nilges
    • , Edward H. Egelman
    • , Nadia Izadi-Pruneyre
    •  & Olivera Francetic
  • Article |

    Fluorescent d-amino acid incorporation reveals host–prey cell wall modification during Bdellovibrio bacteriovorus predation including pore formation and l,d-transpeptidase-mediated prey strengthening.

    • Erkin Kuru
    • , Carey Lambert
    • , Jonathan Rittichier
    • , Rob Till
    • , Adrien Ducret
    • , Adeline Derouaux
    • , Joe Gray
    • , Jacob Biboy
    • , Waldemar Vollmer
    • , Michael VanNieuwenhze
    • , Yves V. Brun
    •  & R. Elizabeth Sockett
  • Article |

    Levulinic acid (LA) is a value-added chemical easily obtained from biomass. The pathway enabling LA degradation in Pseudomonas putida requires five enzymes and can be engineered into Escherichia coli, which could enable further biotechnological applications.

    • Jacqueline M. Rand
    • , Tippapha Pisithkul
    • , Ryan L. Clark
    • , Joshua M. Thiede
    • , Christopher R. Mehrer
    • , Daniel E. Agnew
    • , Candace E. Campbell
    • , Andrew L. Markley
    • , Morgan N. Price
    • , Jayashree Ray
    • , Kelly M. Wetmore
    • , Yumi Suh
    • , Adam P. Arkin
    • , Adam M. Deutschbauer
    • , Daniel Amador-Noguez
    •  & Brian F. Pfleger
  • Article | | open

    The recovery of 7,903 bacterial and archaeal metagenome-assembled genomes increases the phylogenetic diversity represented by public genome repositories and provides the first representatives from 20 candidate phyla.

    • Donovan H. Parks
    • , Christian Rinke
    • , Maria Chuvochina
    • , Pierre-Alain Chaumeil
    • , Ben J. Woodcroft
    • , Paul N. Evans
    • , Philip Hugenholtz
    •  & Gene W. Tyson
  • Article |

    The structures of a variant surface glycoprotein (VSG) from Trypanosoma brucei suggest that VSGs adopt different conformations to respond to obstacles present in the cell membrane, enabling them to maintain a protective coat at all times.

    • Thomas Bartossek
    • , Nicola G. Jones
    • , Christin Schäfer
    • , Mislav Cvitković
    • , Marius Glogger
    • , Helen R. Mott
    • , Jochen Kuper
    • , Martha Brennich
    • , Mark Carrington
    • , Ana-Sunčana Smith
    • , Susanne Fenz
    • , Caroline Kisker
    •  & Markus Engstler
  • Article |

    CD81 is shown to interact with SAMHD1 and lead to its proteasomal degradation, thereby impacting dNTP availability and enhancing HIV-1 reverse transcription in primary human T cells.

    • Vera Rocha-Perugini
    • , Henar Suárez
    • , Susana Álvarez
    • , Soraya López-Martín
    • , Gina M. Lenzi
    • , Felipe Vences-Catalán
    • , Shoshana Levy
    • , Baek Kim
    • , María A. Muñoz-Fernández
    • , Francisco Sánchez-Madrid
    •  & Maria Yáñez-Mó
  • Article |

    TRIM23 is identified as an essential regulator of virus-induced autophagy that mediates restriction to several RNA and DNA viruses. K27-mediated ubiquitylation activates TRIM23 GTPase activity, triggering its relocalization and selective autophagy.

    • Konstantin M. J. Sparrer
    • , Sebastian Gableske
    • , Matthew A. Zurenski
    • , Zachary M. Parker
    • , Florian Full
    • , Gavin J. Baumgart
    • , Jiro Kato
    • , Gustavo Pacheco-Rodriguez
    • , Chengyu Liang
    • , Owen Pornillos
    • , Joel Moss
    • , Martha Vaughan
    •  & Michaela U. Gack
  • Article |

    Chikungunya virus infection leads to painful arthritis-like joint inflammation. This study shows that the NLRP3 inflammasome is crucial for alphavirus-induced inflammation and its inhibition is an effective therapeutic strategy.

    • Weiqiang Chen
    • , Suan-Sin Foo
    • , Ali Zaid
    • , Terk-Shin Teng
    • , Lara J. Herrero
    • , Stefan Wolf
    • , Kothila Tharmarajah
    • , Luan D. Vu
    • , Caryn van Vreden
    • , Adam Taylor
    • , Joseph R. Freitas
    • , Rachel W. Li
    • , Trent M. Woodruff
    • , Richard Gordon
    • , David M. Ojcius
    • , Helder I. Nakaya
    • , Thirumala-Devi Kanneganti
    • , Luke A. J. O’Neill
    • , Avril A. B. Robertson
    • , Nicholas J. King
    • , Andreas Suhrbier
    • , Matthew A. Cooper
    • , Lisa F. P. Ng
    •  & Suresh Mahalingam
  • Article |

    This study reports the identification of broadly protective antibodies targeting the influenza B neuraminidase away from its active site. One dose of antibody therapy was more protective in mice than multiple doses of the current standard of care.

    • Teddy John Wohlbold
    • , Kira A. Podolsky
    • , Veronika Chromikova
    • , Ericka Kirkpatrick
    • , Veronica Falconieri
    • , Philip Meade
    • , Fatima Amanat
    • , Jessica Tan
    • , Benjamin R. tenOever
    • , Gene S. Tan
    • , Sriram Subramaniam
    • , Peter Palese
    •  & Florian Krammer
  • Article |

    Both African and epidemic strains of Zika virus are shown to target CD14+ monocytes, which are more susceptible in pregnant women, but African strains are associated with inflammatory responses, and epidemic strains with immunotolerance.

    • Suan-Sin Foo
    • , Weiqiang Chen
    • , Yen Chan
    • , James W. Bowman
    • , Lin-Chun Chang
    • , Younho Choi
    • , Ji Seung Yoo
    • , Jianning Ge
    • , Genhong Cheng
    • , Alexandre Bonnin
    • , Karin Nielsen-Saines
    • , Patrícia Brasil
    •  & Jae U. Jung
  • Article |

    A new class of drugs, hexahydroquinolines, inhibits host haemoglobin endocytosis by Plasmodium falciparum and displays both therapeutic and transmission-blocking activities.

    • Manu Vanaerschot
    • , Leonardo Lucantoni
    • , Tao Li
    • , Jill M. Combrinck
    • , Andrea Ruecker
    • , T. R. Santha Kumar
    • , Kelly Rubiano
    • , Pedro E. Ferreira
    • , Giulia Siciliano
    • , Sonia Gulati
    • , Philipp P. Henrich
    • , Caroline L. Ng
    • , James M. Murithi
    • , Victoria C. Corey
    • , Sandra Duffy
    • , Ori J. Lieberman
    • , M. Isabel Veiga
    • , Robert E. Sinden
    • , Pietro Alano
    • , Michael J. Delves
    • , Kim Lee Sim
    • , Elizabeth A. Winzeler
    • , Timothy J. Egan
    • , Stephen L. Hoffman
    • , Vicky M. Avery
    •  & David A. Fidock
  • Article |

    During acute HIV type 1 infection, a subset of γδ T cells that express Δ42PD1 are shown to home to the gut, where they activate innate immunity and inflammation through direct interaction of Δ42PD1 with Toll-like receptor 4. Blockade of this pathway reduces mucosal damage.

    • Allen Ka Loon Cheung
    • , Hau-yee Kwok
    • , Yiru Huang
    • , Min Chen
    • , Yufei Mo
    • , Xilin Wu
    • , Ka-shing Lam
    • , Hoi-Kuan Kong
    • , Terrence Chi Kong Lau
    • , Jingying Zhou
    • , Jingjing Li
    • , Lin Cheng
    • , Boon Kiat Lee
    • , Qiaoli Peng
    • , Xiaofan Lu
    • , Minghui An
    • , Hui Wang
    • , Hong Shang
    • , Boping Zhou
    • , Hao Wu
    • , Aimin Xu
    • , Kwok-Yung Yuen
    •  & Zhiwei Chen
  • Article |

    A genome-wide association approach identifies differential biofilm and virulence attributes associated with mortality in two Staphylococcus aureus clonal complexes.

    • Mario Recker
    • , Maisem Laabei
    • , Michelle S. Toleman
    • , Sandra Reuter
    • , Rebecca B. Saunderson
    • , Beth Blane
    • , M. Estee Török
    • , Khadija Ouadi
    • , Emily Stevens
    • , Maho Yokoyama
    • , Joseph Steventon
    • , Luke Thompson
    • , Gregory Milne
    • , Sion Bayliss
    • , Leann Bacon
    • , Sharon J. Peacock
    •  & Ruth C. Massey
  • Article |

    The group A streptococcal M protein virulence factor induces inflammasome activation during infection.

    • J. Andrés Valderrama
    • , Angelica M. Riestra
    • , Nina J. Gao
    • , Christopher N. LaRock
    • , Naveen Gupta
    • , Syed Raza Ali
    • , Hal M. Hoffman
    • , Partho Ghosh
    •  & Victor Nizet
  • Article |

    In situ analysis of natural Crocosphaera populations revealed diel cycling of transcript abundances for a range of metabolic pathways, indicating that these cyanobacteria are dominant nitrogen fixers and contributors to primary productivity.

    • Samuel T. Wilson
    • , Frank O. Aylward
    • , Francois Ribalet
    • , Benedetto Barone
    • , John R. Casey
    • , Paige E. Connell
    • , John M. Eppley
    • , Sara Ferrón
    • , Jessica N. Fitzsimmons
    • , Christopher T. Hayes
    • , Anna E. Romano
    • , Kendra A. Turk-Kubo
    • , Alice Vislova
    • , E. Virginia Armbrust
    • , David A. Caron
    • , Matthew J. Church
    • , Jonathan P. Zehr
    • , David M. Karl
    •  & Edward F. DeLong
  • Article |

    A structural analysis of the C-terminal extension of DotL and its binding partners DotN, IcmS, IcmW and LvgA elucidates how the type IV secretion system (T4SS) of Legionella pneumophila mediates the recruitment of T4SS effectors.

    • Mi-Jeong Kwak
    • , J. Dongun Kim
    • , Hyunmin Kim
    • , Cheolhee Kim
    • , James W. Bowman
    • , Seonghoon Kim
    • , Keehyoung Joo
    • , Jooyoung Lee
    • , Kyeong Sik Jin
    • , Yeon-Gil Kim
    • , Nam Ki Lee
    • , Jae U. Jung
    •  & Byung-Ha Oh
  • Article |

    A lack of models has hindered the study of Ebola virus (EBOV) persistence and sequelae, which are now shown to occur in rhesus monkeys. Progressive EBOV spread into eyes, brain and testes with CD68+ cells as the cryptic EBOV reservoir.

    • Xiankun Zeng
    • , Candace D. Blancett
    • , Keith A. Koistinen
    • , Christopher W. Schellhase
    • , Jeremy J. Bearss
    • , Sheli R. Radoshitzky
    • , Shelley P. Honnold
    • , Taylor B. Chance
    • , Travis K. Warren
    • , Jeffrey W. Froude
    • , Kathleen A. Cashman
    • , John M. Dye
    • , Sina Bavari
    • , Gustavo Palacios
    • , Jens H. Kuhn
    •  & Mei G. Sun
  • Article |

    Development of a broad-spectrum β-lactamase inhibitor capable of combatting multidrug-resistant pathogens, including Acinetobacter baumannii.

    • Thomas F. Durand-Réville
    • , Satenig Guler
    • , Janelle Comita-Prevoir
    • , Brendan Chen
    • , Neil Bifulco
    • , Hoan Huynh
    • , Sushmita Lahiri
    • , Adam B. Shapiro
    • , Sarah M. McLeod
    • , Nicole M. Carter
    • , Samir H. Moussa
    • , Camilo Velez-Vega
    • , Nelson B. Olivier
    • , Robert McLaughlin
    • , Ning Gao
    • , Jason Thresher
    • , Tiffany Palmer
    • , Beth Andrews
    • , Robert A. Giacobbe
    • , Joseph V. Newman
    • , David E. Ehmann
    • , Boudewijn de Jonge
    • , John O'Donnell
    • , John P. Mueller
    • , Rubén A. Tommasi
    •  & Alita A. Miller