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Vaccinia virus recruits host proteins to promote viral release from infected cells. This is achieved by the viral protein A36, which contains three NPF motifs that interact with the host proteins intersectin-1 and Eps15.
Spatial correlation between microbial communities and chemical gradients within a lake system was observed, with few organisms capable of sulphate reduction, supporting microbial cooperation for geochemical functioning
The Mouse Intestinal Bacterial Collection (miBC) is a public repository of bacterial strains and associated genomes from the mouse gut. A minimal consortium of 18 species covered 50–75% of the known functional potential.
The cryoEM structures of Ebola virus GP and sGP in complex with GP-specific and GP/sGP cross-reactive antibodies provides insight into the oligomeric arrangement of sGP and a comparison of its structure and epitope presentation with GP.
Pseudomonas aeruginosa infection induces host microRNA miR-301b via a TLR4-dependent pathway in order to block c-Myb inflammatory cytokine signalling and neutrophil infiltration.
Measurements of mercury species and metagenomic analyses of Antarctic snow, brine, sea ice, and seawater suggest that mercury methylation may be conducted by the marine microaerophilic bacterium Nitrospina in Antarctic sea ice.
A phylogenetic approach was used to illuminate the physiology of the last universal common ancestor, supporting the theory that LUCA was an H2-dependent autotroph in a hydrothermal setting rich in hydrogen, carbon dioxide and iron.
Murine sepsis models and humans with established acute respiratory distress syndrome harbour a lung microbiome enriched in viable gut-associated bacteria and were correlated with inflammation intensity.
The skin microbiome in patients prone to atopic dermatitis is enriched in Streptococcus and Gemella, and is associated with an adaptive immune response, an altered eukaryotic community and a functional shift in the microbiome-wide gene repertoire.
Modulation of the gut microbiota in mice with oral treatment of W27 immunoglobulin A had a therapeutic effect on lymphoproliferative disease and colitis models in mice.
Long colonic transit times are associated with high microbial richness and a shift towards protein catabolism, whilst short transit times are associated with a possible increase in colonic mucosa renewal.
Non-structural protein-1 (NS1) of dengue virus (DENV) and Japanese encephalitis virus (JEV) are secreted into the serum of an infected host where they facilitate virus transmission by overcoming the immune barrier in the midgut of their mosquito vector.
A lentiviral screening platform for camelid-derived antibody fragments (VHHs) identifies 19 antiviral VHHs that protect human cells from influenza A virus or vesicular stomatitis virus by preventing vRNP nuclear import or mRNA transcription.
Organisms previously thought to be endemic to marine hydrothermal vents have been found in the pelagic realm, albeit at low abundance, supporting the open ocean seed bank hypothesis for the colonization of geographically distant vent habitats.
A manually curated metabolic module framework for (meta)genomic data analysis identifies species-function relationships in gut microbial genomes and microbiomes, revealing significant genus-level metabolic diversification linked to bacterial life-strategy.
Shigella flexneri effectors, IpaH1.4 and IpaH2.5, target the E3 linear ubiquitin chain ligase complex (LUBAC) for degradation to inhibit downstream immune signalling during infection.
