Articles

Previous Escherichia coli infection epigenetically alters host epithelial cell maturation and COX-2 mediated inflammation to predispose mice for future recurrent infection.

‘Candidatus Udaeobacter copiosus’ is found to be one of the most abundant microorganisms across >1,000 soil samples. Metabolic reconstruction of the small genome suggests it is an aerobic heterotroph with multiple auxotrophies.

A small-molecule inhibitor that blocks the ATPase activity of the cellular human transcription/export complex (hTREX) protein UAP56 prevents the formation of Kaposi's sarcoma associated herpesvirus (KSHV) viral ribonucleoprotein particles (vRNPs)

The metabolomes of 260 strains of Pseudomonas were indexed, enabling the discovery and evolutionary relationships of 4 molecules — a poaeamide analogue, and the bananamides 1, 2 and 3 — a molecular sub-family of cyclic lipopeptides.

Calcium activates the two-component histidine kinase LadS to induce the Gac/Rsm chronic virulence regulatory program in Pseudomonas aeruginosa.

The S-oxidizing symbiont of the bivalve Codakia orbicularis encodes all proteins required for biological nitrogen fixation. The symbiont's NifH is phylogenetically close to free-living N-fixing Proteobacteria associated with seagrass sediment.

The chemosynthetic symbionts of the bivalve Loripes lucinalis and nematode Laxus oneistus are found to encode nitrogen fixation genes, with evidence for active nitrogen fixation.

Direct genome sequencing from clinical samples shows that Treponema pallidum experiences diversification during host infection.

The Helicobacter pylori outer membrane protein HopQ interacts with human CEACAMs to mediate bacterial attachment.

During bacterial infection, tryptophanyl-tRNA synthetase is secreted by monocytes and binds to macrophages via a TLR4–MD2 complex to induce phagocytosis and chemokine production, thereby serving as a primary defence system against infection.

Outer membrane protein HopQ binds human CEACAMs and serves as an adhesin for Helicobacter pylori.

Metagenomic, metatranscriptomic and metaproteomic approaches are used to resolve the taxonomic and functional characteristics of gastrointestinal microbiota from four families with multiple cases of type 1 diabetes mellitus.

Staphylococcus aureus utilizes its type VII secretion system to export a nuclease that targets non-immune bacterial competitors.

Phylogenetic analysis defines the population and transmission structure of Listeria monocytogenes isolates and creates a global framework for epidemiological surveillance.Phylogenetic analysis defines the population and transmission structure of Listeria monocytogenes isolates and creates a global framework for epidemiological surveillance.

The Verstraetearchaeota encode divergent methyl-coenzyme M reductase genes, which are required for methylotrophic methanogenesis, increasing methanogen diversity and the complexity of the global methane cycle.

The Pseudomonas aeruginosa quorum-sensing molecule 2-aminoacetophenone (2-AA) upregulates HDAC1 to reduce acetylation at cytokine promoters and promote host tolerance during infection.

Whole-genome sequencing suggests that the spread of multidrug-resistant Enterobacter cloacae infections in the UK and Ireland is driven by a diverse community-based pool of strains.

A symbiosis between the root-inhabiting Enterobacter sp. M6 and the finger millet creates a physical barrier around the roots, trapping and killing the fungus Fusarium graminearum via M6-derived release of fungicides into the barrier matrix.

Immunization with inactivated Japanese encephalitis vaccine generates cross-reactive antibodies that enhance immunogenicity on subsequent immunization with live attenuated yellow fever vaccine, demonstrating antibody-dependent enhancement of infection in a clinical trial.

Mutations in two previously unreported Plasmodium falciparum genes, acetyl-CoA transporter (pfact) and UDP-galactose transporter (pfugt), convey resistance to two imidazolopiperazine antimalarial compounds.