Browse Articles

  • News & Views |

    Glycolytic Staphylococcus aureus generate lactate that targets specific histone deacetylases to stimulate the production of IL-10 and enable biofilm formation.

    • Alice Prince
  • Author Correction |

    • José-María López-Lozano
    • , Timothy Lawes
    • , César Nebot
    • , Arielle Beyaert
    • , Xavier Bertrand
    • , Didier Hocquet
    • , Mamoon Aldeyab
    • , Michael Scott
    • , Geraldine Conlon-Bingham
    • , David Farren
    • , Gábor Kardos
    • , Adina Fésűs
    • , Jesús Rodríguez-Baño
    • , Pilar Retamar
    • , Nieves Gonzalo-Jiménez
    • , Ian M. Gould
    • , José-María López-Lozano
    • , Timothy Lawes
    • , César Nebot
    • , Arielle Beyaert
    • , Xavier Bertrand
    • , Didier Hocquet
    • , Mamoon Aldeyab
    • , Michael Scott
    • , Geraldine Conlon-Bingham
    • , David Farren
    • , Gábor Kardos
    • , Adina Fésus
    • , Jesús Rodríguez-Baño
    • , Pilar Retamar
    • , Nieves Gonzalo-Jiménez
    • , Ian M. Gould
    • , María Núñez-Núñez
    • , Ana I. Suárez
    • , Michelle Thouverez
    • , María Navarro-Cots
    • , Emilio Borrajo
    • , Carlos Devesa
    • , Joan Gregori
    • , Inmaculada González Cuello
    • , Isabel Pacheco
    • , María Cerón
    •  & Hajnalka Tóth
  • Article |

    Very-long-chain fatty acids (VLCFAs) mediate recruitment of septins to the plasma membrane in fungal appressoria, leading to formation of a septin ring at the point of plant infection. VLCFA biosynthesis-inhibiting chemicals prevent septin assembly and have broad-spectrum fungicidal activity.

    • Min He
    • , Jia Su
    • , Youpin Xu
    • , Jinhua Chen
    • , Mawsheng Chern
    • , Mingliang Lei
    • , Tuo Qi
    • , Zongkuan Wang
    • , Lauren S. Ryder
    • , Bozeng Tang
    • , Míriam Osés-Ruiz
    • , Keke Zhu
    • , Yuyan Cao
    • , Xia Yan
    • , Iris Eisermann
    • , Yuan Luo
    • , Weitao Li
    • , Jing Wang
    • , Junjie Yin
    • , Sin Man Lam
    • , Guoxiong Peng
    • , Xiaofang Sun
    • , Xiaobo Zhu
    • , Bingtian Ma
    • , Jichun Wang
    • , Jiali Liu
    • , Hai Qing
    • , Li Song
    • , Long Wang
    • , Qingqing Hou
    • , Peng Qin
    • , Yan Li
    • , Jing Fan
    • , Deqiang Li
    • , Yuping Wang
    • , Xiue Wang
    • , Ling Jiang
    • , Guanghou Shui
    • , Yuxian Xia
    • , Guoshu Gong
    • , Fu Huang
    • , Wenming Wang
    • , Xianjun Wu
    • , Ping Li
    • , Lihuang Zhu
    • , Shigui Li
    • , Nicholas J. Talbot
    •  & Xuewei Chen
  • Article |

    Using single-particle analysis cryogenic electron microscopy, the authors determine the structures of the bacterial flagellum stator complexes from three diverse bacteria.

    • Justin C. Deme
    • , Steven Johnson
    • , Owen Vickery
    • , Amy Muellbauer
    • , Holly Monkhouse
    • , Thomas Griffiths
    • , Rory Hennell James
    • , Ben C. Berks
    • , James W. Coulton
    • , Phillip J. Stansfeld
    •  & Susan M. Lea
  • Article |

    Cryo-electron microscopy structures of three varicella-zoster virus (VZV) capsids show VZV-specific features of the capsid-associated tegument complex (CATC) and genome packaging. The authors conclude that the VZV capsid is less stable and the CATC binds more weakly than in the homologues in other herpesviruses, characteristics that are linked to the small genome size of VZV.

    • Wei Wang
    • , Qingbing Zheng
    • , Dequan Pan
    • , Hai Yu
    • , Wenkun Fu
    • , Jian Liu
    • , Maozhou He
    • , Rui Zhu
    • , Yuze Cai
    • , Yang Huang
    • , Zhenghui Zha
    • , Zhenqin Chen
    • , Xiangzhong Ye
    • , Jinle Han
    • , Yuqiong Que
    • , Ting Wu
    • , Jun Zhang
    • , Shaowei Li
    • , Hua Zhu
    • , Z. Hong Zhou
    • , Tong Cheng
    •  & Ningshao Xia
  • Article |

    Preclinical studies show that fluoxazolevir, which inhibits the fusion of hepatitis C virus (HCV) with hepatic cells by binding viral envelope protein 1, could be useful in drug cocktails to treat HCV.

    • Christopher D. Ma
    • , Michio Imamura
    • , Daniel C. Talley
    • , Adam Rolt
    • , Xin Xu
    • , Amy Q. Wang
    • , Derek Le
    • , Takuro Uchida
    • , Mitsutaka Osawa
    • , Yuji Teraoka
    • , Kelin Li
    • , Xin Hu
    • , Seung Bum Park
    • , Nishanth Chalasani
    • , Parker H. Irvin
    • , Andres E. Dulcey
    • , Noel Southall
    • , Juan J. Marugan
    • , Zongyi Hu
    • , Kazuaki Chayama
    • , Kevin J. Frankowski
    •  & Tsanyang Jake Liang
  • News & Views |

    The dogma that conversion of the RNA genome of HIV into DNA occurs in the cytoplasm before nuclear entry is challenged using nuclear pore blockade experiments.

    • Nathalie Jane Arhel
  • Article |

    Transcriptional and functional immune-cell profiling reveals that Candida auris is a strong inducer of innate host defence and identifies possible targets for adjuvant immunotherapy.

    • Mariolina Bruno
    • , Simone Kersten
    • , Judith M. Bain
    • , Martin Jaeger
    • , Diletta Rosati
    • , Michael D. Kruppa
    • , Douglas W. Lowman
    • , Peter J. Rice
    • , Bridget Graves
    • , Zuchao Ma
    • , Yue Ning Jiao
    • , Anuradha Chowdhary
    • , George Renieris
    • , Frank L. van de Veerdonk
    • , Bart-Jan Kullberg
    • , Evangelos J. Giamarellos-Bourboulis
    • , Alexander Hoischen
    • , Neil A. R. Gow
    • , Alistair J. P. Brown
    • , Jacques F. Meis
    • , David L. Williams
    •  & Mihai G. Netea
  • Article
    | Open Access

    Large freshwater phage genomes can encode the pmoC gene, an important subunit of the methane oxidation enzyme, methane monooxygenase. These genes are similar to bacterial homologues and are actively expressed in situ. Further work is needed to confirm whether these phages contribute to methane oxidation in the environment.

    • Lin-Xing Chen
    • , Raphaël Méheust
    • , Alexander Crits-Christoph
    • , Katherine D. McMahon
    • , Tara Colenbrander Nelson
    • , Gregory F. Slater
    • , Lesley A. Warren
    •  & Jillian F. Banfield
  • Article |

    The authors do a CRISPR-knockout selection to investigate host factors required for influenza replication. They identified IFIT2 as being repurposed by influenza to promote replication.

    • Vy Tran
    • , Mitchell P. Ledwith
    • , Thiprampai Thamamongood
    • , Christina A. Higgins
    • , Shashank Tripathi
    • , Max W. Chang
    • , Christopher Benner
    • , Adolfo García-Sastre
    • , Martin Schwemmle
    • , Adrianus C. M. Boon
    • , Michael S. Diamond
    •  & Andrew Mehle
  • Article |

    Outer membrane vesicles from Neisseria gonorrhoeae and other Gram-negative pathogens can kill macrophages via induction of mitochondrial apoptosis and activation of the pro-apoptotic BCL-2 family member BAK, and activate the NLRP3 inflammasome.

    • Pankaj Deo
    • , Seong H. Chow
    • , Mei-Ling Han
    • , Mary Speir
    • , Cheng Huang
    • , Ralf B. Schittenhelm
    • , Subhash Dhital
    • , Jack Emery
    • , Jian Li
    • , Benjamin T. Kile
    • , James E. Vince
    • , Kate E. Lawlor
    •  & Thomas Naderer
  • Article |

    Dissimilatory sulfate reduction in archaeon ‘Candidatus Vulcanisaeta moutnovskia’ is distinct from bacterial sulfate reduction and sheds light on the evolution of sulfur metabolism.

    • Nikolay A. Chernyh
    • , Sinje Neukirchen
    • , Evgenii N. Frolov
    • , Filipa L. Sousa
    • , Margarita L. Miroshnichenko
    • , Alexander Y. Merkel
    • , Nikolay V. Pimenov
    • , Dimitry Y. Sorokin
    • , Sergio Ciordia
    • , María Carmen Mena
    • , Manuel Ferrer
    • , Peter N. Golyshin
    • , Alexander V. Lebedinsky
    • , Inês A. Cardoso Pereira
    •  & Elizaveta A. Bonch-Osmolovskaya
  • Letter |

    Identification of the entire set of genes needed for multi-drug plasmid IncC conjugation will inform efforts to prevent plasmid spread.

    • Steven J. Hancock
    • , Minh-Duy Phan
    • , Zhenyao Luo
    • , Alvin W. Lo
    • , Kate M. Peters
    • , Nguyen Thi Khanh Nhu
    • , Brian M. Forde
    • , Jason Whitfield
    • , Ji Yang
    • , Richard A. Strugnell
    • , David L. Paterson
    • , Timothy R. Walsh
    • , Bostjan Kobe
    • , Scott A. Beatson
    •  & Mark A. Schembri
  • Author Correction |

    • Thomas D. Otto
    • , Aude Gilabert
    • , Thomas Crellen
    • , Ulrike Böhme
    • , Céline Arnathau
    • , Mandy Sanders
    • , Samuel O. Oyola
    • , Alain Prince Okouga
    • , Larson Boundenga
    • , Eric Willaume
    • , Barthélémy Ngoubangoye
    • , Nancy Diamella Moukodoum
    • , Christophe Paupy
    • , Patrick Durand
    • , Virginie Rougeron
    • , Benjamin Ollomo
    • , François Renaud
    • , Chris Newbold
    • , Matthew Berriman
    •  & Franck Prugnolle
  • Article |

    This study describes design automation and predictable gene regulatory network engineering in a eukaryotic microorganism.

    • Ye Chen
    • , Shuyi Zhang
    • , Eric M. Young
    • , Timothy S. Jones
    • , Douglas Densmore
    •  & Christopher A. Voigt
  • Article |

    This study describes the mechanism by which Chlamydia trachomatis reprogrammes host glutamine metabolism in a c-Myc-dependent manner. The authors show that glutamine uptake via the SLC15A transporter and glutaminolysis are crucial for peptidoglycan synthesis and Chlamydia replication.

    • Karthika Rajeeve
    • , Nadine Vollmuth
    • , Sudha Janaki-Raman
    • , Thomas F. Wulff
    • , Apoorva Baluapuri
    • , Francesca R. Dejure
    • , Claudia Huber
    • , Julian Fink
    • , Maximilian Schmalhofer
    • , Werner Schmitz
    • , Rajeeve Sivadasan
    • , Elmar Wolf
    • , Wolfgang Eisenreich
    • , Almut Schulze
    • , Jürgen Seibel
    •  & Thomas Rudel
  • Article |

    In this manuscript, the authors address evolutionary questions on the emergence of SARS-CoV-2. They find that SARS-CoV-2 is not a recombinant of any sarbecoviruses detected to date, and that the bat and pangolin sequences most closely related to SARS-CoV-2 probably diverged several decades ago or possibly earlier from human SARS-CoV-2 samples.

    • Maciej F. Boni
    • , Philippe Lemey
    • , Xiaowei Jiang
    • , Tommy Tsan-Yuk Lam
    • , Blair W. Perry
    • , Todd A. Castoe
    • , Andrew Rambaut
    •  & David L. Robertson
  • Article |

    This study reveals features of Epstein–Barr virus that are similar but not identical to the closely related Kaposi’s sarcoma-associated herpesvirus. The authors provide locations of protein components within the viral capsid and reveal different conformers of protein components by revealing variations in links between capsid proteins and exploiting approaches with relaxation of symmetry. The capsid-associated tegument complex is loaded on to the capsid with long-range asymmetry, relative to the location of the portal vertex (the site of genome entry and egress).

    • Wei Liu
    • , Yanxiang Cui
    • , Caiyan Wang
    • , Zihang Li
    • , Danyang Gong
    • , Xinghong Dai
    • , Guo-Qiang Bi
    • , Ren Sun
    •  & Z. Hong Zhou
  • Article |

    This study reveals that prion-like domains support the assembly of transcription factor complexes that control fungal cell identity and highlights parallels with the ‘super-enhancers’ that regulate mammalian cell fate.

    • Corey Frazer
    • , Mae I. Staples
    • , Yoori Kim
    • , Matthew Hirakawa
    • , Maureen A. Dowell
    • , Nicole V. Johnson
    • , Aaron D. Hernday
    • , Veronica H. Ryan
    • , Nicolas L. Fawzi
    • , Ilya J. Finkelstein
    •  & Richard J. Bennett
  • Letter |

    Subinhibitory levels of sulfamethoxazole, an antibiotic used to treat Escherichia coli infections, trigger a previously undescribed metabolic pathway in E. coli that comprises a family of hybrid pterin–phenylpyruvate conjugates called colipterins. These metabolites are antioxidants, have immunomodulatory properties and improve colitis in a murine model.

    • Hyun Bong Park
    • , Zheng Wei
    • , Joonseok Oh
    • , Hao Xu
    • , Chung Sub Kim
    • , Rurun Wang
    • , Thomas P. Wyche
    • , Grazia Piizzi
    • , Richard A. Flavell
    •  & Jason M. Crawford
  • News & Views |

    A virus has been found inserted into the genome of the most abundant bacteria in the oceans. Even though the virus can kill its host, the genes carried by the prophage may help these bacteria flourish around the world.

    • David L. Kirchman
  • News & Views |

    A dual-mechanism compound with antibacterial activity that targets both folate metabolism and membrane integrity, with a favourable resistance profile in vitro, is identified by screening a small molecule library.

    • Ursula Theuretzbacher
  • News & Views |

    Marine bacteria that produce an enormous panoply of glycan-degrading enzymes are identified as having a role in releasing fixed carbon present in glycan-rich cell walls of brown algae.

    • Fiona Cuskin
    •  & Elisabeth C. Lowe
  • News & Views |

    Iron-scavenging molecules called siderophores that are produced by the native microbial residents of plant roots fend off plant pathogens such as Ralstonia solanacearum.

    • Shaul Pollak
    •  & Otto X. Cordero
  • Letter |

    Here, the authors identify lymphocyte antigen 6E (LY6E) as a coronavirus (CoV) restriction factor that prevents infection of B cells and dendritic cells. LY6E inhibits both human and mouse CoV entry into cells by interfering with viral spike protein-mediated membrane fusion. It facilitates an antiviral immune response that prevents liver disease and reduces death in the mouse model of MHV-A59 CoV infection.

    • Stephanie Pfaender
    • , Katrina B. Mar
    • , Eleftherios Michailidis
    • , Annika Kratzel
    • , Ian N. Boys
    • , Philip V’kovski
    • , Wenchun Fan
    • , Jenna N. Kelly
    • , Dagny Hirt
    • , Nadine Ebert
    • , Hanspeter Stalder
    • , Hannah Kleine-Weber
    • , Markus Hoffmann
    • , Hans-Heinrich Hoffmann
    • , Mohsan Saeed
    • , Ronald Dijkman
    • , Eike Steinmann
    • , Mary Wight-Carter
    • , Matthew B. McDougal
    • , Natasha W. Hanners
    • , Stefan Pöhlmann
    • , Tom Gallagher
    • , Daniel Todt
    • , Gert Zimmer
    • , Charles M. Rice
    • , John W. Schoggins
    •  & Volker Thiel
  • Article
    | Open Access

    Metagenomic analysis of a single RNA virome from the Yangshan Deep-Water Harbour in China enabled the recovery of more than 4,500 distinct RNA viruses, doubling the known set of RNA viruses to date, and provided insights into their biology.

    • Yuri I. Wolf
    • , Sukrit Silas
    • , Yongjie Wang
    • , Shuang Wu
    • , Michael Bocek
    • , Darius Kazlauskas
    • , Mart Krupovic
    • , Andrew Fire
    • , Valerian V. Dolja
    •  & Eugene V. Koonin
  • Article |

    Vpu prevents HIV superinfection and immune activation by modulating DNA repair mechanisms, particularly by inhibiting homologous repair. Vpu achieves this by disrupting the RanBP2–RanGAP1*SUMO1–Ubc9 complex at the nuclear pore to reduce PML SUMOylation and consequent PML nuclear body formation, which hampers the homologous recombination factors Rad52 and BLM.

    • Meta Volcic
    • , Konstantin M. J. Sparrer
    • , Lennart Koepke
    • , Dominik Hotter
    • , Daniel Sauter
    • , Christina M. Stürzel
    • , Myriam Scherer
    • , Thomas Stamminger
    • , Thomas G. Hofmann
    • , Nathalie J. Arhel
    • , Lisa Wiesmüller
    •  & Frank Kirchhoff
  • Article |

    The AcP10 protein—an active uridine kinase, encoded by the beluga whale coronavirus SW1—is an antagonist of the integrated stress response that acts downstream of phosphorylation of the translation initiation factor eIF2, irrespective of which eIF2 kinase is activated. AcP10 acts as a competitive inhibitor of the eIF2[P]–eIF2B interaction by binding to eIF2B. A protein with a similar function is also encoded by Aichivirus, a picornavirus.

    • Huib H. Rabouw
    • , Linda J. Visser
    • , Tim C. Passchier
    • , Martijn A. Langereis
    • , Fan Liu
    • , Piero Giansanti
    • , Arno L. W. van Vliet
    • , José G. Dekker
    • , Susanne G. van der Grein
    • , Jesús G. Saucedo
    • , Aditya A. Anand
    • , Mikael E. Trellet
    • , Alexandre M. J. J. Bonvin
    • , Peter Walter
    • , Albert J. R. Heck
    • , Raoul J. de Groot
    •  & Frank J. M. van Kuppeveld
  • Article |

    The authors propose a nomenclature of SARS-CoV-2 lineages to assist research on epidemiology and decision-making during the COVID-19 pandemic. This nomenclature is based on the SARS-CoV-2 phylogeny and designed to provide a real-time bird’s-eye view of the diversity of the hundreds of thousands of genome sequences collected worldwide. The authors develop a set of rules to produce a hierarchical four-level nomenclature of labels that is flexible and dynamic.

    • Andrew Rambaut
    • , Edward C. Holmes
    • , Áine O’Toole
    • , Verity Hill
    • , John T. McCrone
    • , Christopher Ruis
    • , Louis du Plessis
    •  & Oliver G. Pybus
  • Article |

    This study highlights a unique drug target for trypanosomatid parasitic protozoa and a new chemical tool for investigating the function of their divergent kinetochores.

    • Manuel Saldivia
    • , Eric Fang
    • , Xiaolei Ma
    • , Elmarie Myburgh
    • , Juliana B. T. Carnielli
    • , Christopher Bower-Lepts
    • , Elaine Brown
    • , Ryan Ritchie
    • , Suresh B. Lakshminarayana
    • , Yen-Liang Chen
    • , Debjani Patra
    • , Elizabeth Ornelas
    • , Hazel X. Y. Koh
    • , Sarah L. Williams
    • , Frantisek Supek
    • , Daniel Paape
    • , Richard McCulloch
    • , Marcel Kaiser
    • , Michael P. Barrett
    • , Jan Jiricek
    • , Thierry T. Diagana
    • , Jeremy C. Mottram
    •  & Srinivasa P. S. Rao
  • Article |

    In this Article, the authors report the discovery of a small molecule (GHP-88309) that is a new class of allosteric viral polymerase inhibitor that works against two different genera of paramyxoviruses.

    • Robert M. Cox
    • , Julien Sourimant
    • , Mart Toots
    • , Jeong-Joong Yoon
    • , Satoshi Ikegame
    • , Mugunthan Govindarajan
    • , Ruth E. Watkinson
    • , Patricia Thibault
    • , Negar Makhsous
    • , Michelle J. Lin
    • , Jose R. Marengo
    • , Zachary Sticher
    • , Alexander A. Kolykhalov
    • , Michael G. Natchus
    • , Alexander L. Greninger
    • , Benhur Lee
    •  & Richard K. Plemper
  • Article |

    Adenovirus produces two early proteins, E1B55K and E4orf6, that become components of the host cell ubiquitin ligase complex comprising elongin-B and C, cullin-5 and RBX1. The authors identified new protein substrates that are ubiquitinated by the E1B55K–E4orf6 complex and find that hnRNP-C and RALY play an inhibitory role on late viral RNA transcripts and that this is counteracted by ubiquitination due to a reduction on the capacity of these proteins to interact with viral RNA.

    • Christin Herrmann
    • , Joseph M. Dybas
    • , Jennifer C. Liddle
    • , Alexander M. Price
    • , Katharina E. Hayer
    • , Richard Lauman
    • , Caitlin E. Purman
    • , Matthew Charman
    • , Eui Tae Kim
    • , Benjamin A. Garcia
    •  & Matthew D. Weitzman
  • Article |

    Bacteria-derived lactate mediates inhibition of HDAC11 during Staphylococcus aureus biofilm infections, resulting in epigenetic changes that reprogramme the host immune response.

    • Cortney E. Heim
    • , Megan E. Bosch
    • , Kelsey J. Yamada
    • , Amy L. Aldrich
    • , Sujata S. Chaudhari
    • , David Klinkebiel
    • , Casey M. Gries
    • , Abdulelah A. Alqarzaee
    • , Yixuan Li
    • , Vinai C. Thomas
    • , Edward Seto
    • , Adam R. Karpf
    •  & Tammy Kielian
  • Analysis |

    This is a comparative analysis of the performance of the primer–probe sets from four open-source molecular diagnostic assays for SARS-CoV-2 recommended by the World Health Organization.

    • Chantal B. F. Vogels
    • , Anderson F. Brito
    • , Anne L. Wyllie
    • , Joseph R. Fauver
    • , Isabel M. Ott
    • , Chaney C. Kalinich
    • , Mary E. Petrone
    • , Arnau Casanovas-Massana
    • , M. Catherine Muenker
    • , Adam J. Moore
    • , Jonathan Klein
    • , Peiwen Lu
    • , Alice Lu-Culligan
    • , Xiaodong Jiang
    • , Daniel J. Kim
    • , Eriko Kudo
    • , Tianyang Mao
    • , Miyu Moriyama
    • , Ji Eun Oh
    • , Annsea Park
    • , Julio Silva
    • , Eric Song
    • , Takehiro Takahashi
    • , Manabu Taura
    • , Maria Tokuyama
    • , Arvind Venkataraman
    • , Orr-El Weizman
    • , Patrick Wong
    • , Yexin Yang
    • , Nagarjuna R. Cheemarla
    • , Elizabeth B. White
    • , Sarah Lapidus
    • , Rebecca Earnest
    • , Bertie Geng
    • , Pavithra Vijayakumar
    • , Camila Odio
    • , John Fournier
    • , Santos Bermejo
    • , Shelli Farhadian
    • , Charles S. Dela Cruz
    • , Akiko Iwasaki
    • , Albert I. Ko
    • , Marie L. Landry
    • , Ellen F. Foxman
    •  & Nathan D. Grubaugh
  • Article |

    Productive influenza infection can be improved by cooperation and this varies between viral strains and hosts. By quantifying the rates of reassortment and virus production using several methods, including single-cell sequencing, the authors find that isolates of the avian H9N2 influenza subtype are dependent on infections with a second virus, but only in mammalian cells and not in avian cells. These findings are supported by in vivo experiments in guinea pigs and quail. The authors find indications that this type of cooperation between influenza A viruses depends on the RNA polymerase subunit PA.

    • Kara L. Phipps
    • , Ketaki Ganti
    • , Nathan T. Jacobs
    • , Chung-Young Lee
    • , Silvia Carnaccini
    • , Maria C. White
    • , Miglena Manandhar
    • , Brett E. Pickett
    • , Gene S. Tan
    • , Lucas M. Ferreri
    • , Daniel R. Perez
    •  & Anice C. Lowen
  • Article |

    Isolation of phages associated with the gut commensal Bacteroides thetaiotaomicron reveals a link between cell surface structures, including phase-variable capsular polysaccharides, lipoproteins and S-layer proteins, and susceptibility to phage infection.

    • Nathan T. Porter
    • , Andrew J. Hryckowian
    • , Bryan D. Merrill
    • , Jaime J. Fuentes
    • , Jackson O. Gardner
    • , Robert W. P. Glowacki
    • , Shaleni Singh
    • , Ryan D. Crawford
    • , Evan S. Snitkin
    • , Justin L. Sonnenburg
    •  & Eric C. Martens
  • News & Views |

    Cooperative behaviour enables populations of yeast cells to survive high temperatures.

    • Kevin R. Lauterjung
    • , Neydis Moreno Morales
    •  & Megan N. McClean
  • News & Views |

    Some cytosolic bacteria deform the plasma membrane to spread from cell to cell. Secretion of 25-hydroxy-cholesterol by macrophages has emerged as a protective response that depletes the cholesterol pool used by these bacteria to disseminate through epithelia.

    • Norma W. Andrews
  • News & Views |

    Monkeypox, a zoonotic disease that is marked in humans by a smallpox-like rash, may present as a rash-less respiratory disease in wild chimpanzees.

    • Jens H. Kuhn
  • Letter |

    A microbiome genome-wide association study using three large European cohorts identified several significant study-wide and genome-wide correlations between human genetic variants and microbial traits, and used Mendelian randomization to estimate causal relationships between microbial traits and disease.

    • David A. Hughes
    • , Rodrigo Bacigalupe
    • , Jun Wang
    • , Malte C. Rühlemann
    • , Raul Y. Tito
    • , Gwen Falony
    • , Marie Joossens
    • , Sara Vieira-Silva
    • , Liesbet Henckaerts
    • , Leen Rymenans
    • , Chloë Verspecht
    • , Susan Ring
    • , Andre Franke
    • , Kaitlin H. Wade
    • , Nicholas J. Timpson
    •  & Jeroen Raes