Browse Articles

  • News & Views |

    The secondary metabolite cepacin A is the essential compound made by Burkholderia ambifaria needed for biocontrol of plant pathogens. In this organism, genes responsible for virulence and for cepacin A biosynthesis reside on different replicons, allowing for the engineering of avirulent mutants that retain their biocontrol properties.

    • Tom Coenye
  • News & Views |

    A recent study finds that viruses cooperate altruistically to overcome innate host immunity and that this can be explained in the same way we explain altruism between animals.

    • Asher Leeks
    •  & Stuart West
  • News & Views |

    A class of drugs approved to treat schizophrenia can cause rapid loss of the pilus, an essential virulence factor necessary for the disease-causing properties in the strict human pathogen Neisseria meningitidis.

    • H Steven Seifert
  • Editorial |

    Long-known to happen in other realms of the microscopic and macroscopic worlds, social interactions in viruses are increasingly being appreciated and have the potential to influence many processes, including viral pathogenesis, resistance to antiviral immunity, establishment of persistence and even life cycle choice.

  • News & Views |

    Differences in microbial genomes can result in vastly different phenotypes and functions. Consequently, it is critical to understand the genome variations that differentiate microbial strains. Here, we discuss recent exciting advances that enable structural variant measurement, their associated phenotypes and the horizon for future discovery.

    • Matthew G. Durrant
    •  & Ami S. Bhatt
  • Article |

    The electron cryo-microscopy structure of Sulfolobus islandicus pili enabled the identification of SiL_2606 as the main pilin in these filaments and revealed that the pili are glycosylated, which probably explains how these structures remain soluble and stable even when cells grow at pH 3 and 80 °C.

    • Fengbin Wang
    • , Virginija Cvirkaite-Krupovic
    • , Mark A. B. Kreutzberger
    • , Zhangli Su
    • , Guilherme A. P. de Oliveira
    • , Tomasz Osinski
    • , Nicholas Sherman
    • , Frank DiMaio
    • , Joseph S. Wall
    • , David Prangishvili
    • , Mart Krupovic
    •  & Edward H. Egelman
  • Article |

    VacA promotes Helicobacter pylori intracellular localization and persistence in the face of antibiotics. Activation of the lysosomal TRPML1 calcium channel reverses VacA toxicity and promotes bacterial clearance during drug treatment.

    • Mariana I. Capurro
    • , Laura K. Greenfield
    • , Akriti Prashar
    • , Sunny Xia
    • , Majd Abdullah
    • , Harikesh Wong
    • , Xi Zoe Zhong
    • , Nina Bertaux-Skeirik
    • , Jayati Chakrabarti
    • , Iram Siddiqui
    • , Catherine O’Brien
    • , Xianping Dong
    • , Lisa Robinson
    • , Richard M. Peek Jr
    • , Dana J. Philpott
    • , Yana Zavros
    • , Michael Helmrath
    •  & Nicola L. Jones
  • Article |

    Leukotriene B4 signalling contributes to disease tolerance to influenza virus infection by stimulating the production of interferon-α (IFN-α) by interstitial macrophages. IFN-α, in turn, suppresses in situ inflammatory, monocyte-derived macrophage proliferation and mitigates lung immunopathology.

    • Erwan Pernet
    • , Jeffrey Downey
    • , Donald C. Vinh
    • , William S. Powell
    •  & Maziar Divangahi
  • Article | | open

    Using metagenomics and proteomics on Mediterranean grassland soil samples resulted in the recovery of 793 metagenome-assembled genomes and provided insights into microbial activity in this environment, and how this changes with soil depth and exposure to extended rainfall.

    • Spencer Diamond
    • , Peter F. Andeer
    • , Zhou Li
    • , Alexander Crits-Christoph
    • , David Burstein
    • , Karthik Anantharaman
    • , Katherine R. Lane
    • , Brian C. Thomas
    • , Chongle Pan
    • , Trent R. Northen
    •  & Jillian F. Banfield
  • Article |

    The GTPase MglA, its cognate GTPase activating protein (GAP) MglB and RomR are known to regulate gliding motility in Myxococcus xanthus. There are no known cognate guanine nucleotide exchange factors (GEFs) for MglA. Here, RomX is identified as a binding partner of RomR, and their complex serves as an MglA GEF.

    • Dobromir Szadkowski
    • , Andrea Harms
    • , Luis António Menezes Carreira
    • , Manon Wigbers
    • , Anna Potapova
    • , Kristin Wuichet
    • , Daniela Keilberg
    • , Ulrich Gerland
    •  & Lotte Søgaard-Andersen
  • Article |

    Direct interaction of influenza virus with Gram-positive and Gram-negative bacterial pathogens of the respiratory tract results in increased bacterial adherence to respiratory epithelial cells in culture and in higher bacterial burdens in vivo.

    • Hannah M. Rowe
    • , Victoria A. Meliopoulos
    • , Amy Iverson
    • , Perrine Bomme
    • , Stacey Schultz-Cherry
    •  & Jason W. Rosch
  • Article |

    Mycobacterium tuberculosis secreted protein MPT53 mediates the activation of TAK1 and induces the host immune inflammatory response.

    • Lin Wang
    • , Zhonghua Liu
    • , Jie Wang
    • , Haipeng Liu
    • , Juehui Wu
    • , Tianqi Tang
    • , Haohao Li
    • , Hua Yang
    • , Lianhua Qin
    • , Dapeng Ma
    • , Jianxia Chen
    • , Feng Liu
    • , Peng Wang
    • , Ruijuan Zheng
    • , Peng Song
    • , Yilong Zhou
    • , Zhenling Cui
    • , Xiangyang Wu
    • , Xiaochen Huang
    • , Haijiao Liang
    • , Shanshan Zhang
    • , Jingjing Cao
    • , Chunyan Wu
    • , Yiping Chen
    • , Dan Su
    • , Xinchun Chen
    • , Gucheng Zeng
    •  & Baoxue Ge
  • Article |

    Co-administration of a whole-inactivated influenza virus (IAV) vaccine (γ-Flu) with a whole-inactivated Streptococcus pneumoniae vaccine (γ-PN) enhances IAV-specific immune responses due to the ability of γ-PN to directly interact with γ-Flu, thus increasing viral uptake by macrophages.

    • Shannon C. David
    • , Todd Norton
    • , Timona Tyllis
    • , Jasmine J. Wilson
    • , Eve V. Singleton
    • , Zoe Laan
    • , Justin Davies
    • , Timothy R. Hirst
    • , Iain Comerford
    • , Shaun R. McColl
    • , James C. Paton
    •  & Mohammed Alsharifi
  • Article |

    Phylogenetic analysis based on a concatenated set of 77 single-copy marker genes enabled the classification of tailed double-stranded DNA viruses from large datasets, and was reproducible across software and models, providing a framework that could be applied to other viruses.

    • Soo Jen Low
    • , Mária Džunková
    • , Pierre-Alain Chaumeil
    • , Donovan H. Parks
    •  & Philip Hugenholtz
  • Article |

    SEDS family peptidoglycan transglycosylases, RodA and FtsW, in Staphylococcus aureus pair with the cognate transpeptidases PBP3 and PBP1 to mediate sidewall elongation and septal peptidoglycan incorporation, respectively, and maintain coccoid morphology.

    • Nathalie T. Reichmann
    • , Andreia C. Tavares
    • , Bruno M. Saraiva
    • , Ambre Jousselin
    • , Patricia Reed
    • , Ana R. Pereira
    • , João M. Monteiro
    • , Rita G. Sobral
    • , Michael S. VanNieuwenhze
    • , Fábio Fernandes
    •  & Mariana G. Pinho
  • Article |

    Global sampling of microbial communities associated with wastewater treatment plants and application of ecological theory revealed a small, core bacterial community associated with performance and provides insights into the community dynamics in this environment.

    • Linwei Wu
    • , Daliang Ning
    • , Bing Zhang
    • , Yong Li
    • , Ping Zhang
    • , Xiaoyu Shan
    • , Qiuting Zhang
    • , Mathew Brown
    • , Zhenxin Li
    • , Joy D. Van Nostrand
    • , Fangqiong Ling
    • , Naijia Xiao
    • , Ya Zhang
    • , Julia Vierheilig
    • , George F. Wells
    • , Yunfeng Yang
    • , Ye Deng
    • , Qichao Tu
    • , Aijie Wang
    • , Dany Acevedo
    • , Miriam Agullo-Barcelo
    • , Pedro J. J. Alvarez
    • , Lisa Alvarez-Cohen
    • , Gary L. Andersen
    • , Juliana Calabria de Araujo
    • , Kevin Boehnke
    • , Philip Bond
    • , Charles B. Bott
    • , Patricia Bovio
    • , Rebecca K. Brewster
    • , Faizal Bux
    • , Angela Cabezas
    • , Léa Cabrol
    • , Si Chen
    • , Craig S. Criddle
    • , Ye Deng
    • , Claudia Etchebehere
    • , Amanda Ford
    • , Dominic Frigon
    • , Janeth Sanabria Gómez
    • , James S. Griffin
    • , April Z. Gu
    • , Moshe Habagil
    • , Lauren Hale
    • , Steven D. Hardeman
    • , Marc Harmon
    • , Harald Horn
    • , Zhiqiang Hu
    • , Shameem Jauffur
    • , David R. Johnson
    • , Jurg Keller
    • , Alexander Keucken
    • , Sheena Kumari
    • , Cintia Dutra Leal
    • , Laura A. Lebrun
    • , Jangho Lee
    • , Minjoo Lee
    • , Zarraz M. P. Lee
    • , Yong Li
    • , Zhenxin Li
    • , Mengyan Li
    • , Xu Li
    • , Fangqiong Ling
    • , Yu Liu
    • , Richard G. Luthy
    • , Leda C. Mendonça-Hagler
    • , Francisca Gleire Rodriguez de Menezes
    • , Arthur J. Meyers
    • , Amin Mohebbi
    • , Per H. Nielsen
    • , Daliang Ning
    • , Adrian Oehmen
    • , Andrew Palmer
    • , Prathap Parameswaran
    • , Joonhong Park
    • , Deborah Patsch
    • , Valeria Reginatto
    • , Francis L. de los Reyes III
    • , Bruce E. Rittmann
    • , Adalberto Noyola Robles
    • , Simona Rossetti
    • , Xiaoyu Shan
    • , Jatinder Sidhu
    • , William T. Sloan
    • , Kylie Smith
    • , Oscarina Viana de Sousa
    • , David A. Stahl
    • , Kyle Stephens
    • , Renmao Tian
    • , James M. Tiedje
    • , Nicholas B. Tooker
    • , Qichao Tu
    • , Joy D. Van Nostrand
    • , Daniel De los Cobos Vasconcelos
    • , Julia Vierheilig
    • , Michael Wagner
    • , Steve Wakelin
    • , Aijie Wang
    • , Bei Wang
    • , Joseph E. Weaver
    • , George F. Wells
    • , Stephanie West
    • , Paul Wilmes
    • , Sung-Geun Woo
    • , Linwei Wu
    • , Jer-Horng Wu
    • , Liyou Wu
    • , Chuanwu Xi
    • , Naijia Xiao
    • , Meiying Xu
    • , Tao Yan
    • , Yunfeng Yang
    • , Min Yang
    • , Michelle Young
    • , Haowei Yue
    • , Bing Zhang
    • , Ping Zhang
    • , Qiuting Zhang
    • , Ya Zhang
    • , Tong Zhang
    • , Qian Zhang
    • , Wen Zhang
    • , Yu Zhang
    • , Hongde Zhou
    • , Jizhong Zhou
    • , Xianghua Wen
    • , Thomas P. Curtis
    • , Qiang He
    • , Zhili He
    • , Matthew Brown
    • , Tong Zhang
    • , Zhili He
    • , Jurg Keller
    • , Per H. Nielsen
    • , Pedro J. J. Alvarez
    • , Craig S. Criddle
    • , Michael Wagner
    • , James M. Tiedje
    • , Qiang He
    • , Thomas P. Curtis
    • , David A. Stahl
    • , Lisa Alvarez-Cohen
    • , Bruce E. Rittmann
    • , Xianghua Wen
    •  & Jizhong Zhou
  • Letter |

    A combination of microfluidic devices, transcriptomic analyses and reporter strains shows that Pseudomonas aeruginosa modulates gene expression in response to shear flow. This process, termed rheosensing, does not require known surface sensors and is regulated by the alternative sigma factor FroR.

    • Joseph E. Sanfilippo
    • , Alexander Lorestani
    • , Matthias D. Koch
    • , Benjamin P. Bratton
    • , Albert Siryaporn
    • , Howard A. Stone
    •  & Zemer Gitai
  • Letter |

    Here, the authors identify a mutualistic symbiosis between a non-motile, magnetic deltaproteobacterium and a protist, resulting in eukaryotic magnetoreception in marine anoxic sediments.

    • Caroline L. Monteil
    • , David Vallenet
    • , Nicolas Menguy
    • , Karim Benzerara
    • , Valérie Barbe
    • , Stéphanie Fouteau
    • , Corinne Cruaud
    • , Magali Floriani
    • , Eric Viollier
    • , Géraldine Adryanczyk
    • , Nathalie Leonhardt
    • , Damien Faivre
    • , David Pignol
    • , Purificación López-García
    • , Richard J. Weld
    •  & Christopher T. Lefevre
  • Brief Communication |

    The authors report the development of a Madin-Darby canine kidney (MDCK) cell line that is more suitable than conventional MDCK or human virus receptor-overexpressing cells for the isolation and propagation of human influenza viruses without cell culture-adaptive mutations.

    • Kosuke Takada
    • , Chiharu Kawakami
    • , Shufang Fan
    • , Shiho Chiba
    • , Gongxun Zhong
    • , Chunyang Gu
    • , Kohei Shimizu
    • , Sara Takasaki
    • , Yuko Sakai-Tagawa
    • , Tiago J. S. Lopes
    • , Jayeeta Dutta
    • , Zenab Khan
    • , Divya Kriti
    • , Harm van Bakel
    • , Shinya Yamada
    • , Tokiko Watanabe
    • , Masaki Imai
    •  & Yoshihiro Kawaoka
  • Article |

    Following export from the parasite, the dense granule-resident effector TEEGR travels to the host cell nucleus where it interferes with host transcription factors to modulate immune signalling and regulate Toxoplasma persistence.

    • Laurence Braun
    • , Marie-Pierre Brenier-Pinchart
    • , Pierre-Mehdi Hammoudi
    • , Dominique Cannella
    • , Sylvie Kieffer-Jaquinod
    • , Julien Vollaire
    • , Véronique Josserand
    • , Bastien Touquet
    • , Yohann Couté
    • , Isabelle Tardieux
    • , Alexandre Bougdour
    •  & Mohamed-Ali Hakimi
  • News & Views |

    Computational analysis of fungal genomes revealed that some early-branching fungi use selenocysteine, the selenium-containing amino acid, that was thought to be missing from proteins in this lineage.

    • Sergi Castellano
  • News & Views |

    Inflammatory molecules evolved partly to protect hosts from viruses, but increasing evidence suggests that they cause disease pathology and chronic conditions, and play a role in aging. By mitigating these effects, bats are able to both tolerate viral infections and live well beyond expectations.

    • David T. S. Hayman
  • News & Views |

    A large-scale comparative genomic survey of Cryptosporidium species and subtypes reveals a cryptic anthroponotic Cryptosporidium parvum branch and a large, recent superclade of species and subtypes that undergo genetic exchange, potentially facilitating host associations.

    • Jessica C. Kissinger
  • Editorial |

    Access to life-saving vaccines is still a problem for millions around the world, while others endanger public health by refusing available, safe and effective vaccines. Yet some outbreaks increasingly occur in highly vaccinated populations, highlighting the need for further vaccine development to provide long-lasting immunity.

  • Article |

    A combination of electron cryotomography and immunofluorescence microscopy reveals the structure of the core transmembrane subcomplex of the Legionella defective in organelle trafficking (Dot)/intracellular multiplication (Icm) type IVB secretion system (T4BSS) and an early-stage assembly process by which T4BSS components are targeted to the bacterial poles by DotU and IcmF.

    • Debnath Ghosal
    • , Kwangcheol C. Jeong
    • , Yi-Wei Chang
    • , Jacob Gyore
    • , Lin Teng
    • , Adam Gardner
    • , Joseph P. Vogel
    •  & Grant J. Jensen
  • Letter |

    Using a short-hairpin RNA-based depletion strategy coupled with high throughput RNA sequencing, the authors unravel a layer of intrinsic immunity to positive-strand RNA viruses in immortalized hepatocytes that relies on basal expression levels of interferon regulatory factor 1 maintaining the transcription of a suite of antiviral genes.

    • Daisuke Yamane
    • , Hui Feng
    • , Efraín E. Rivera-Serrano
    • , Sara R. Selitsky
    • , Asuka Hirai-Yuki
    • , Anshuman Das
    • , Kevin L. McKnight
    • , Ichiro Misumi
    • , Lucinda Hensley
    • , William Lovell
    • , Olga González-López
    • , Ryosuke Suzuki
    • , Mami Matsuda
    • , Hiroki Nakanishi
    • , Takayo Ohto-Nakanishi
    • , Takayuki Hishiki
    • , Eliane Wauthier
    • , Tsunekazu Oikawa
    • , Kouichi Morita
    • , Lola M. Reid
    • , Praveen Sethupathy
    • , Michinori Kohara
    • , Jason K. Whitmire
    •  & Stanley M. Lemon
  • Article |

    The ADP-ribosyltransferase PARP11 promotes ubiquitination and degradation of the interferon type I (IFN-I) receptor IFNAR1 by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP, thus suppressing the IFN-I-mediated antiviral responses both in vitro and in vivo.

    • Tingting Guo
    • , Yibo Zuo
    • , Liping Qian
    • , Jin Liu
    • , Yukang Yuan
    • , Kailin Xu
    • , Ying Miao
    • , Qian Feng
    • , Xiangjie Chen
    • , Lincong Jin
    • , Liting Zhang
    • , Chunsheng Dong
    • , Sidong Xiong
    •  & Hui Zheng
  • Author Correction |

    • Eric A. Franzosa
    • , Alexandra Sirota-Madi
    • , Julian Avila-Pacheco
    • , Nadine Fornelos
    • , Henry J. Haiser
    • , Stefan Reinker
    • , Tommi Vatanen
    • , A. Brantley Hall
    • , Himel Mallick
    • , Lauren J. McIver
    • , Jenny S. Sauk
    • , Robin G. Wilson
    • , Betsy W. Stevens
    • , Justin M. Scott
    • , Kerry Pierce
    • , Amy A. Deik
    • , Kevin Bullock
    • , Floris Imhann
    • , Jeffrey A. Porter
    • , Alexandra Zhernakova
    • , Jingyuan Fu
    • , Rinse K. Weersma
    • , Cisca Wijmenga
    • , Clary B. Clish
    • , Hera Vlamakis
    • , Curtis Huttenhower
    •  & Ramnik J. Xavier
  • Article |

    A nonlinear time-series analysis was used to identify antibiotic use thresholds that are associated with the emergence of antibiotic resistance.

    • José-María López-Lozano
    • , Timothy Lawes
    • , César Nebot
    • , Arielle Beyaert
    • , Xavier Bertrand
    • , Didier Hocquet
    • , Mamoon Aldeyab
    • , Michael Scott
    • , Geraldine Conlon-Bingham
    • , David Farren
    • , Gábor Kardos
    • , Adina Fésűs
    • , Jesús Rodríguez-Baño
    • , Pilar Retamar
    • , Nieves Gonzalo-Jiménez
    • , Ian M. Gould
    • , José-María López-Lozano
    • , Timothy Lawes
    • , César Nebot
    • , Arielle Beyaert
    • , Xavier Bertrand
    • , Didier Hocquet
    • , Mamoon Aldeyab
    • , Michael Scott
    • , Geraldine Conlon-Bingham
    • , David Farren
    • , Gábor Kardos
    • , Adina Fésus
    • , Jesús Rodríguez-Baño
    • , Pilar Retamar
    • , Nieves Gonzalo-Jiménez
    • , Ian M. Gould
    • , María Núñez-Núñez
    • , Ana I. Suárez
    • , Michelle Thouverez
    • , María Navarro-Cots
    • , Emilio Borrajo
    • , Carlos Devesa
    • , Joan Gregori
    • , Inmaculada García-Cuello
    • , Isabel Pacheco
    • , María Cerón
    •  & Hajnalka Tóth
  • Publisher Correction | | open

    • Moritz U. G. Kraemer
    • , Robert C. Reiner Jr
    • , Oliver J. Brady
    • , Jane P. Messina
    • , Marius Gilbert
    • , David M. Pigott
    • , Dingdong Yi
    • , Kimberly Johnson
    • , Lucas Earl
    • , Laurie B. Marczak
    • , Shreya Shirude
    • , Nicole Davis Weaver
    • , Donal Bisanzio
    • , T. Alex Perkins
    • , Shengjie Lai
    • , Xin Lu
    • , Peter Jones
    • , Giovanini E. Coelho
    • , Roberta G. Carvalho
    • , Wim Van Bortel
    • , Cedric Marsboom
    • , Guy Hendrickx
    • , Francis Schaffner
    • , Chester G. Moore
    • , Heinrich H. Nax
    • , Linus Bengtsson
    • , Erik Wetter
    • , Andrew J. Tatem
    • , John S. Brownstein
    • , David L. Smith
    • , Louis Lambrechts
    • , Simon Cauchemez
    • , Catherine Linard
    • , Nuno R. Faria
    • , Oliver G. Pybus
    • , Thomas W. Scott
    • , Qiyong Liu
    • , Hongjie Yu
    • , G. R. William Wint
    • , Simon I. Hay
    •  & Nick Golding
  • Review Article |

    This Review highlights some of the advances that have been made towards understanding the complexity of differential interferon (IFN) signalling inputs and outputs as well as some of the strategies viruses use to interfere with or circumvent IFN-induced antiviral responses.

    • Emily V. Mesev
    • , Robert A. LeDesma
    •  & Alexander Ploss
  • Article |

    Human DNase I is shown to be overexpressed in hypoxic environments in vitro and to be incorporated into human hepatitis B virus (HBV) particles, resulting in virions devoid of genomic DNA. These findings might help explain the low levels of circulating HBV DNA commonly observed in cirrhotic livers and liver tumours.

    • Camille Hallez
    • , Xiongxiong Li
    • , Rodolphe Suspène
    • , Valérie Thiers
    • , Mohamed S Bouzidi
    • , Cristina M Dorobantu
    • , Vincent Lucansky
    • , Simon Wain-Hobson
    • , Raphaël Gaudin
    •  & Jean-Pierre Vartanian
  • Article |

    The study of the impact of mutations in the glutamate dehydrogenase enzyme from Bacillus subtilis across multiple settings, including liquid cultures, biofilms and in soil, highlights how bacterial growth states and the environment can differentially impact protein evolution.

    • Lianet Noda-García
    • , Dan Davidi
    • , Elisa Korenblum
    • , Assaf Elazar
    • , Ekaterina Putintseva
    • , Asaph Aharoni
    •  & Dan S. Tawfik
  • Letter |

    This study highlights the impact of the gut virome on host immunity by showing that a specific strain of murine astrovirus in the gut of immunodeficient mice protects them against norovirus and rotavirus infections, and that this protection depends on interferon-λ signalling in gut epithelial cells.

    • Harshad Ingle
    • , Sanghyun Lee
    • , Teresa Ai
    • , Anthony Orvedahl
    • , Rachel Rodgers
    • , Guoyan Zhao
    • , Meagan Sullender
    • , Stefan T. Peterson
    • , Marissa Locke
    • , Ta-Chiang Liu
    • , Christine C. Yokoyama
    • , Bridgett Sharp
    • , Stacey Schultz-Cherry
    • , Jonathan J. Miner
    •  & Megan T. Baldridge
  • Letter |

    A comparative analysis of Asgard archaea genomes elucidates their metabolic potential and leads to the proposal of a revised ‘aerobic protoeukaryotes’ model for the origin of the eukaryotic cell.

    • Paul-Adrian Bulzu
    • , Adrian-Ştefan Andrei
    • , Michaela M. Salcher
    • , Maliheh Mehrshad
    • , Keiichi Inoue
    • , Hideki Kandori
    • , Oded Beja
    • , Rohit Ghai
    •  & Horia L. Banciu
  • Article |

    The isolation and characterization of glycoprotein-specific monoclonal antibodies from a patient with Rift Valley fever (RVF) provide insights into the humoral immune responses elicited by the RVF virus as well as the therapeutic potential of antibody-based strategies.

    • Qihui Wang
    • , Tong Ma
    • , Yan Wu
    • , Zhihai Chen
    • , Hui Zeng
    • , Zhou Tong
    • , Feng Gao
    • , Jianxun Qi
    • , Zhennan Zhao
    • , Yan Chai
    • , Huabing Yang
    • , Gary Wong
    • , Yuhai Bi
    • , Lili Wu
    • , Rui Shi
    • , Mi Yang
    • , Jian Song
    • , Haihai Jiang
    • , Zhiqiang An
    • , Junzhi Wang
    • , Tilahun D. Yilma
    • , Yi Shi
    • , William J. Liu
    • , Mifang Liang
    • , Chuan Qin
    • , George F. Gao
    •  & Jinghua Yan
  • Article |

    Here, the authors characterize the symbiotic relationship between Haliclona sponges and its intracellular symbiont. The symbiont has a highly streamlined genome, yet retains a plasmid with the biosynthetic gene cluster for production of the defence chemical renieramycin and lives within chemobacteriocytes for nutrient acquisition.

    • Ma. Diarey Tianero
    • , Jared N. Balaich
    •  & Mohamed S. Donia
  • Letter |

    Strain-level analysis of gut and oral microbiomes from individuals living in the Fiji Islands identified shared genomes particularly within households, indicating potential microbial transmission within social networks.

    • Ilana L. Brito
    • , Thomas Gurry
    • , Shijie Zhao
    • , Katherine Huang
    • , Sarah K. Young
    • , Terrence P. Shea
    • , Waisea Naisilisili
    • , Aaron P. Jenkins
    • , Stacy D. Jupiter
    • , Dirk Gevers
    •  & Eric J. Alm
  • Article |

    Variable susceptibility to Salmonella infection across genetically similar mice from commercial vendors is due to differential colonization of the gut microbiome by endogenous Enterobacteriaceae.

    • Eric M. Velazquez
    • , Henry Nguyen
    • , Keaton T. Heasley
    • , Cheng H. Saechao
    • , Lindsey M. Gil
    • , Andrew W. L. Rogers
    • , Brittany M. Miller
    • , Matthew R. Rolston
    • , Christopher A. Lopez
    • , Yael Litvak
    • , Megan J. Liou
    • , Franziska Faber
    • , Denise N. Bronner
    • , Connor R. Tiffany
    • , Mariana X. Byndloss
    • , Austin J. Byndloss
    •  & Andreas J. Bäumler
  • Letter |

    A combination of genetic analyses of Anopheles species across sub-Saharan Africa, time-series quantification of Plasmodium falciparum prevalence in mosquitoes and Granger causality statistical testing reveals that changes in the genetic structure of a population over short ecological timescales drive Plasmodium dynamics in nature.

    • Markus Gildenhard
    • , Evans K. Rono
    • , Assetou Diarra
    • , Anne Boissière
    • , Priscila Bascunan
    • , Paola Carrillo-Bustamante
    • , Djeneba Camara
    • , Hanne Krüger
    • , Modibo Mariko
    • , Ramata Mariko
    • , Paul Mireji
    • , Sandrine E. Nsango
    • , Julien Pompon
    • , Yara Reis
    • , Martin K. Rono
    • , Pamela B. Seda
    • , Janis Thailayil
    • , Alou Traorè
    • , Cynthia V. Yapto
    • , Parfait Awono-Ambene
    • , Roch K. Dabiré
    • , Abdulaye Diabaté
    • , Daniel Masiga
    • , Flaminia Catteruccia
    • , Isabelle Morlais
    • , Mouctar Diallo
    • , Djibril Sangare
    •  & Elena A. Levashina
  • Article |

    Phenothiazines inhibit Type IV pili function in Neisseria meningitidis and protect against bacterial colonization of blood vessels and lethality during infection.

    • Kevin Denis
    • , Marion Le Bris
    • , Loic Le Guennec
    • , Jean-Philippe Barnier
    • , Camille Faure
    • , Anne Gouge
    • , Haniaa Bouzinba-Ségard
    • , Anne Jamet
    • , Daniel Euphrasie
    • , Beatrice Durel
    • , Nicolas Barois
    • , Philippe Pelissier
    • , Philippe C. Morand
    • , Mathieu Coureuil
    • , Frank Lafont
    • , Olivier Join-Lambert
    • , Xavier Nassif
    •  & Sandrine Bourdoulous
  • News & Views |

    Animal studies have strongly implicated the gut microbiome as a key regulator of brain and behaviour. Recent work using two large population cohorts and bioinformatics tools has strengthened the link between microbial disturbances and depression (or quality of life in general).

    • John F. Cryan
    •  & Timothy G. Dinan