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Narrow-spectrum antibiotic exploits metabolic differences to inhibit Pseudomonas aeruginosa
We characterize the activity of fluorofolin, a potent inhibitor of dihydrofolate reductase, against Pseudomonas aeruginosa. By exploiting a divergence in thymidine metabolism, fluorofolin becomes selective for P. aeruginosa in the presence of thymine, demonstrating that it can be a narrow-spectrum antibiotic for this bacterial pathogen.
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CryoEM structures reveal how the bacterial flagellum rotates and switches direction
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Age-specific nasal epithelial responses to SARS-CoV-2 infection
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Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence
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Life history strategies of soil bacterial communities across global terrestrial biomes