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Volume 7 Issue 9, September 2010

Scanning electron micrograph of a human mesenchymal stem cell grown on an array of posts 12.9 micrometers high. Cover by Erin Dewalt, based on an image provided by Christopher Chen. Brief Communication p733

Editorial

  • A Human Proteome Project has been proposed. To ensure that such a project will have a transformative impact on biology, its scope should be determined by wide and open discussion.

    Editorial

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This Month

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Correspondence

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Research Highlights

  • Researchers designed an enzyme to carry out the Diels-Alder reaction, an activity not found in nature.

    • Allison Doerr
    Research Highlights
  • Application of single-molecule methods to assay genome-wide mRNA and protein levels in single bacteria provides a systems-level view of their relationship.

    • Daniel Evanko
    Research Highlights
  • The strength of selection that acts on a growing population of cells and the presence of a stochastic switching mechanism may be inferred from lineage data.

    • Natalie de Souza
    Research Highlights
  • A trackable multiplex recombineering method in Escherichia coli allows for the identification of genes that affect a selectable trait.

    • Nicole Rusk
    Research Highlights
  • Engineered kinases remain off in cells until turned on by small molecules.

    • Monya Baker
    Research Highlights
  • Single DNA molecules stretched in a nanochannel display melting patterns characteristic of their sequence.

    • Nicole Rusk
    Research Highlights
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Commentary

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Technology Feature

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News & Views

  • The technical toolkit for Caenorhabditis elegans expands to include experimental selection using antibiotic resistance genes.

    • Helen M Chamberlin
    News & Views
  • Arrays of microposts of different heights generate substrates with different flexibility, on which cells can be grown.

    • Amnon Buxboim
    • Dennis E Discher
    News & Views
  • Oxygen concentrations in the rodent brain are revealed at a microscopic scale by measuring the lifetime of two photon–excited phosphorescence.

    • Ulrich Dirnagl
    News & Views
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Resource

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Analysis

  • The authors compare quality metrics of libraries from seven strand-specific RNA-seq methods in terms of complexity, strand specificity, evenness and continuity of coverage, and expression profiling. They provide a computational pipeline to compare these metrics from any RNA-seq protocol.

    • Joshua Z Levin
    • Moran Yassour
    • Aviv Regev
    Analysis
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Brief Communication

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Article

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Advertising Feature: Application Note

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