Volume 20

  • No. 5 May 2023

    Temporal profiling of the secretome

    Capture of secreted proteins onto their source cell surfaces using an affinity matrix enables simultaneous measurement of protein secretion, cell surface proteins and transcriptomes in thousands of cells at single-cell resolution.

    See Wu et al.

  • No. 4 April 2023

    Miniscopes for imaging in mice and juvenile zebra finches

    Miniature head-mounted microscopes provide expansive views of neurons in songbird and mouse brains.

    See Scherrer et al.

  • No. 3 March 2023

    Focus on single-cell proteomics

    Multiple established and emerging technologies are being applied for the analysis of the single-cell proteome, as covered in this month’s Focus on single-cell proteomics.

    See Editorial

  • No. 2 February 2023

    Robust signal separation in multiplexed fluorescence microscopy

    Highly multiplexed fluorescence images of embryonic zebrafish using data analyzed with the Hybrid Unmixing (HyU) method.

    See Chiang et al.

  • No. 1 January 2023

    Method of the Year 2022: Long-read sequencing

    Long-read sequencing is our pick for the Method of the Year 2022, owing to its unparalleled utility in reading genomes, transcriptomes and epigenomes with high accuracy and completeness.

    See Editorial