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Volume 19 Issue 8, August 2022

Monitoring blood flow in the brain at high spatiotemporal resolution

Functional ultrasound localization microscopy reveals whole-brain vascular changes during neuronal activation at high resolution, providing quantitative information on changes in flow, speed and vessel diameter in multiple vascular compartments over a wide field of view.

See Renaudin et al.

Image: Alexandre Dizeux, Physics for Medicine Paris, Inserm. Cover Design: Thomas Phillips.

Editorial

  • In this issue, we are delighted to launch a new regular feature: the Creature Column.

    Editorial

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This Month

  • Tardigrades are everywhere. They’re tiny — usually under a millimeter long — and they’re mostly transparent, so they’re easy to miss. But you probably walk by them every day. We’ve been grooming them as emerging models for studying how body forms evolve and how biological materials can survive extreme conditions.

    • Bob Goldstein
    This Month
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Correspondence

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Comment

  • The study of human–animal chimeras is fraught with technical and ethical challenges. In this Comment, we discuss the importance and future of human–monkey chimera research within the context of current scientific and regulatory obstacles.

    • Alejandro De Los Angeles
    • Alan Regenberg
    • Elias T. Zambidis
    Comment
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Research Highlights

  • Imputing missing parental genotypes sharpens estimates of direct genetic effects.

    • Lin Tang
    Research Highlight
  • Stem cell-derived endothelial cell subtypes enable study of viral tropism.

    • Madhura Mukhopadhyay
    Research Highlight
  • Researchers have discovered two naturally occurring channelrhodopsins for potassium ion transport that can be used in optogenetic applications.

    • Rita Strack
    Research Highlight
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Technology Feature

  • Expeditions are delivering data wealth about our planet’s oceans, including its microbes. Some labs are now diving deep into the ocean virome.

    • Vivien Marx

    Collection:

    Technology Feature
  • Even without a stint on an ocean-faring vessel, scientists can trawl through data to explore marine viruses and address new puzzles and cultural shifts.

    • Vivien Marx

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News & Views

  • Dipole–dipole crosstalk between fluorophores separated by a distance of less than 10 nm induces changes in their photophysics, which adds a challenge to localization microscopy in the sub-10-nm regime.

    • Karim Almahayni
    • Malte Spiekermann
    • Leonhard Möckl
    News & Views
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Research Briefings

  • The Integrative Genome Modeling (IGM) platform incorporates information from multiple, complementary experimental data sources to accurately simulate whole diploid genome structures. We show that such structures have high predictive power and give access to a large variety of structural observables for the characterization of the gene microenvironment.

    Research Briefing
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