Volume 18

  • No. 6 June 2021

    Detect-seq traces the editome of cytosine base editors

    Just as the path of a snail can be traced by the trail of slime it leaves behind, Detect-seq traces the editing-intermediate deoxyuridine to reveal the editome, including different types of off-target mutations induced by cytosine base editors.

    See Lei et al.

  • No. 5 May 2021

    PDB 50th anniversary: celebrating the future of structural biology

    In honor of the 50th anniversary of the Protein Data Bank (PDB), we and our colleagues at Nature Structural & Molecular Biology present a joint special focus issue to celebrate both the past and the future of structural biology.

    See Editorial

  • No. 4 April 2021

    A virtual mouse model for training behavioral analysis algorithms

    A 3D virtual mouse model was generated by adding features such as fur and whiskers to a mesh model of the body. After annotation with landmarks and generation of realistic videos of behavior, the virtual mouse model can be used to train behavioral analysis algorithms.

    See Bolaños et al.

  • No. 3 March 2021

    Deconvoluting RNA structural ensembles

    DRACO is an algorithm for the deconvolution of coexisting alternative RNA conformations from structure probing experiments. When applied to the SARS-CoV-2 genome, DRACO revealed the presence of structurally dynamic regulatory regions, including the frameshifting element and the 3′ UTR.

    See Morandi et al.

  • No. 2 February 2021

    A high-efficiency exosome isolation system

    EXODUS is an ultrafiltration strategy for purifying exosomes from biological fluids with high efficiency. Periodic negative pressure oscillations across a nanoporous membrane filter allow impurities and liquids to pass through while trapping the exosomes in the central chamber.

    See Chen et al.

  • No. 1 January 2021

    Method of the Year: spatially resolved transcriptomics

    Our choice for the 2020 Method of the Year is spatially resolved transcriptomics. The cover depicts an example of data generated by spatially resolved transcriptomics technology. Middle layer: H&E-stained small intestine section. Bottom layer: mRNA capture platform (for example, barcoded microarray or beads). Top layer: RNA-seq data from the small intestine section.

    See Editorial