Volume 17 Issue 11, November 2020

Volume 17 Issue 11

The power of a picture

The cover photo, the winner of Nikon’s Small World Photomicrography Competition, features a juvenile zebrafish captured using fluorescence labeling, confocal microscopy and image stacking. Bones and scales are labeled in blue, lymphatic vessels in orange.

See Editorial

Image: Daniel Castranova, Brant Weinstein & Bakary Samasa. Cover Design: Erin Dewalt.

Editorial

  • Editorial |

    This month, we celebrate the beauty and power of microscopy images.

This Month

  • This Month |

    Neurochemistry sensors for brain research and life with a collaborative frame of mind.

    • Vivien Marx

Correspondence

Research Highlights

Technology Feature

  • Technology Feature |

    Algorithms trained to interpret microscope data can greatly extend the information that can be derived from the resulting images, or even optimize how imaging experiments are conducted.

    • Michael Eisenstein

    Collection:

News & Views

Analysis

Brief Communications

  • Brief Communication |

    vLUME is a complete virtual reality environment for visualizing, analyzing and interacting with three-dimensional single-molecule localization microscopy data.

    • Alexander Spark
    • , Alexandre Kitching
    • , Daniel Esteban-Ferrer
    • , Anoushka Handa
    • , Alexander R. Carr
    • , Lisa-Maria Needham
    • , Aleks Ponjavic
    • , Ana Mafalda Santos
    • , James McColl
    • , Christophe Leterrier
    • , Simon J. Davis
    • , Ricardo Henriques
    •  & Steven F. Lee

Articles

  • Article |

    Long-read metagenomics offers a valuable approach for profiling bacterial communities. This work presents a long-read assembler, metaFlye, that specifically addresses the challenges of assembling metagenomes.

    • Mikhail Kolmogorov
    • , Derek M. Bickhart
    • , Bahar Behsaz
    • , Alexey Gurevich
    • , Mikhail Rayko
    • , Sung Bong Shin
    • , Kristen Kuhn
    • , Jeffrey Yuan
    • , Evgeny Polevikov
    • , Timothy P. L. Smith
    •  & Pavel A. Pevzner

  • Article |

    O-Pair search identifies O-glycopeptides and localizes O-glycosites using a fragment-ion-indexed open modification search combined with a graph-based approach. It also introduces a classification scheme to unify data reporting for glycoproteomics.

    • Lei Lu
    • , Nicholas M. Riley
    • , Michael R. Shortreed
    • , Carolyn R. Bertozzi
    •  & Lloyd M. Smith

  • Article |

    A genetically encoded acetylcholine sensor with improved sensitivity allows detection of cholinergic neurotransmission in vivo in the Drosophila and mouse brain.

    • Miao Jing
    • , Yuexuan Li
    • , Jianzhi Zeng
    • , Pengcheng Huang
    • , Miguel Skirzewski
    • , Ornela Kljakic
    • , Wanling Peng
    • , Tongrui Qian
    • , Ke Tan
    • , Jing Zou
    • , Simon Trinh
    • , Runlong Wu
    • , Shichen Zhang
    • , Sunlei Pan
    • , Samuel A. Hires
    • , Min Xu
    • , Haohong Li
    • , Lisa M. Saksida
    • , Vania F. Prado
    • , Timothy J. Bussey
    • , Marco A. M. Prado
    • , Liangyi Chen
    • , Heping Cheng
    •  & Yulong Li

  • Article |

    Red and yellow versions of the genetically encoded dopamine sensor dLight1 have been developed and allow multiplexed imaging of dopamine with neurotransmitter or cell-type-specific calcium combined with green sensors or actuators, as demonstrated ex vivo and in behaving rodents.

    • Tommaso Patriarchi
    • , Ali Mohebi
    • , Junqing Sun
    • , Aaron Marley
    • , Ruqiang Liang
    • , Chunyang Dong
    • , Kyle Puhger
    • , Grace Or Mizuno
    • , Carolyn M. Davis
    • , Brian Wiltgen
    • , Mark von Zastrow
    • , Joshua D. Berke
    •  & Lin Tian

  • Article |

    Red and improved green versions of the genetically encoded dopamine sensor GRABDA have been developed. These neurotransmitter sensors are used alone or in combination with, for example, calcium sensors in behaving fruit flies and rodents.

    • Fangmiao Sun
    • , Jingheng Zhou
    • , Bing Dai
    • , Tongrui Qian
    • , Jianzhi Zeng
    • , Xuelin Li
    • , Yizhou Zhuo
    • , Yajun Zhang
    • , Yipan Wang
    • , Cheng Qian
    • , Ke Tan
    • , Jiesi Feng
    • , Hui Dong
    • , Dayu Lin
    • , Guohong Cui
    •  & Yulong Li

Amendments & Corrections

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