Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 16 Issue 5, May 2019

Volume 16 Issue 5

Detecting proteins and RNAs in single cells

Artistic rendition of a high-content single-cell CRISPR screen enabled by a multimodal phenotyping tool.

See Mimitou et al.

Image: New York Genome Center / Vincent Dittmer. Cover design: Erin Dewalt.


  • Editorial |

    Dispelling stigmas and highlighting benefits of the Nature Research manuscript transfer service.

This Month

  • This Month |

    His enhancer-discovery tool cisTopic is both wet-lab and dry-lab. John Coltrane matters, too.

    • Vivien Marx

Research Highlights

Technology Feature


  • Perspective |

    This paper reviews the cryo-EM technique of microcrystal electron diffraction (MicroED), providing a broad overview of the technique, the unique structures determined, and the opportunities for future development.

    • Brent L. Nannenga
    •  & Tamir Gonen


  • Analysis |

    Among 17 measures of association tested, measures of proportionality consistently performed well for inference of gene and cellular networks, cell clusters and links to disease from scRNA-seq data. In contrast, several widely used measures of association performed well on only a subset of tasks.

    • Michael A. Skinnider
    • , Jordan W. Squair
    •  & Leonard J. Foster

Brief Communications


Amendments & Corrections


Quick links