Volume 15

  • No. 12 December 2018

    Function-guided circuit manipulation

    Artistic representation of imaged brain activity in larval zebrafish.

    See Vladimirov et al.

  • No. 11 November 2018

    Winner of the 2018 Nikon Small World photomicrography contest

    Eye of a Metapocyrtus subquadrulifer beetle. This image was the winner of the 2018 Nikon Small World photomicrography contest.

  • No. 10 October 2018

    Analyzing neural activity in single trials

    Artistic representation of the dynamic nature of neuronal network activity.

    See Pandarinath et al.

  • No. 9 September 2018

    Cell segmentation on the cloud

    3D rendering of mitochondria in a single Purkinje cell, derived from cloud-based segmentation of volumetric electron microscopy data.

    See Haberl et al.

  • No. 8 August 2018

    Precise, automated neuron reconstruction

    Reconstruction of neurons in zebra finch area X using segmentation by flood-filling networks.

    See Januszewski et al.

  • No. 7 July 2018

    CRISPR off-target analysis in rodents

    A CRISPR-edited mosaic founder mouse with unique genetic editing events at targets and off-targets in subpopulations of cells. Cover art was inspired by the classic mosaic ‘unswept floor’.

    See Anderson et al.

  • No. 6 June 2018

    3D super-resolution microscopy at depth

    Composite of a depth-encoded super-resolution image of the actin cytoskeleton in a human fibroblast cell, as well as interferograms and intensity–phase images underlying the SELFI 3D super-resolution microscopy approach.

    See Bon et al.

  • No. 5 May 2018

    Escherichia coli depicted with the historical mechanical feedback system called the 'governor', commonly seen on engines. The governor is a proportional feedback controller that helps to autoregulate production/power tradeoffs. Artistic rendition by Ella Maru, adapted by Erin Dewalt.

  • No. 4 April 2018

    On the cover: a cellular model learned by an artificial neural network. Cover design by Erin Dewalt, based on a concept by Jianzhu Ma, Samson Fong, Michael Yu and Trey Ideker. p290

  • No. 3 March 2018

    Stylistic rendering of an array of nanopores sequencing single RNA molecules. Drawn by Peter Inkpen, iemedia solutions and adapted by Erin Dewalt, SpringerNature. p201

  • No. 2 February 2018

    A structural protein interactome may be used to map genomic variants that cause disease. The image is based on the epidemiological map generated by John Snow to trace the water pump source of an 1854 cholera outbreak in London. The Snow map was modified by Juan Felipe Beltrán and Haiyuan Yu, p107

  • No. 1 January 2018

    We have chosen organoids as the Method of the Year 2017, for their potential in human development and disease research. Stylized miniature organs lie above issue covers from 2017 in this cover design by Erin Dewalt.