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Volume 15 Issue 11, November 2018

Winner of the 2018 Nikon Small World photomicrography contest

Eye of a Metapocyrtus subquadrulifer beetle. This image was the winner of the 2018 Nikon Small World photomicrography contest.

Image: Yousef Al Habshi. Cover design: Erin Dewalt.

Editorial

  • The NIH BRAIN Initiative is currently in its fifth year. We reflect on its impact on methods development at a time when the program’s future direction is under discussion.

    Editorial

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This Month

  • An optogenetic tool for inhibiting neurons and how to sail across the Tree of Life.

    • Vivien Marx
    This Month
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Correspondence

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Comment

  • Public data archives are the backbone of modern biological research. Biomolecular archives are well established, but bioimaging resources lag behind them. The technology required for imaging archives is now available, thus enabling the creation of the first public bioimage datasets. We present the rationale for the construction of bioimage archives and their associated databases to underpin the next revolution in bioinformatics discovery.

    • Jan Ellenberg
    • Jason R. Swedlow
    • Ewan Birney
    Comment Open Access
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Research Highlights

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Technology Feature

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News & Views

  • A type of neural network first described in 2015 can be trained to translate between images of the same field of view acquired by different modalities. Trained networks can use information inherent in grayscale images of cells to predict fluorescent signals.

    • Roger Brent
    • Laura Boucheron
    News & Views
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Review Articles

  • A review of cellular barcoding fundamentals and applications, including powerful approaches for lineage reconstruction, genetic screening, and the recording of cellular activity and neuroanatomy.

    • Justus M. Kebschull
    • Anthony M. Zador
    Review Article
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Resources

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Brief Communications

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Articles

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Amendments & Corrections

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