News & Comment

Organoids are an emerging way to model the fraught complexity of tumors.

Collaborations between researchers and companies can progress swimmingly and teams quickly validate findings and mature methods. All too often, things can’t advance and the ‘Valley of Death’ looms. New ways to collaborate, underpinned by computational muscle, can help.

Human cells contain crowds of protein variants, but, especially in a time of funding challenges, chasing these proteoforms takes dogged persistence.

As money pours into aging research, the field can combine its many methods to home in on what underpins aging. Approaches differ, but researchers share the desire to not overpromise quick-fix anti-aging methods.

Ultrasound-based modalities are revealing the brain’s inner workings with steadily increasing speed, resolution and depth.

Making biological research more sustainable requires an accurate assessment of its environmental impact, both at the bench and on the computer.

Researchers like the gene-editing method called prime editing for its precision and versatility. As they ask the method to do more, many factors shape what happens next.

To study soil with a view to ecosystems, researchers iterate between experiments in the lab, the field and controlled environments.

Wrangling big data is now part of being a biomedical scientist, and mandates on data sharing have entered the scene. Mandates can alter behavior, but data sharing also needs incentives and shifts in science culture.

As they pursue their puzzles of interest, scientists are inventive caretakers of the organisms in their keep, especially the young.

Chemical modifications to DNA, histones and RNA make changes happen. Scientists are exploring ways to track these modifications and how they interact.

The tumor microenvironment is a source of cancer’s strength. Multi-omics and new spatial techniques stand to find ways to weaken it.

New instruments are emerging in single-cell and single-molecule proteomics. This will offer labs a choice of technologies.

To gain insight into cell function, researchers are tracking the cytoskeleton and its parts, such as actin. They combine methods, find new trackers and validate them.

A rapidly evolving toolbox is helping researchers to get a handle on the biological and functional diversity of these ubiquitous — but still somewhat enigmatic — cell-secreted nanoparticles

Patch-seq delivers morphology, electrophysiology and transcriptomic data to those with skill, patience and persistence.

Researchers roll up their sleeves for the work ahead in the noncoding RNA field.

The research community focused on noncoding RNAs keeps growing. Skepticism about the field has some history.

As new technology enables researchers to find and characterize less-common post-translational modifications that drive gene expression and cellular metabolism, the movement to catalog the entire human proteome gains momentum

Expeditions are delivering data wealth about our planet’s oceans, including its microbes. Some labs are now diving deep into the ocean virome.