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  • A software platform for analyzing data-independent acquisition (DIA) proteomics data.

    • Arunima Singh
    Research Highlight
  • Constructing a fair and accurate author list can be one of the most fraught aspects of manuscript publication. We provide some advice and resources for authors at all career levels.

    Editorial
  • Researchers use an in vitro assay in combination with a polymer model to study protein–DNA condensation and how condensates bring distant DNA elements into close proximity.

    • Lei Tang
    Research Highlight
  • A co-culture system to mimic the development of functional mouse oocytes in vitro.

    • Madhura Mukhopadhyay
    Research Highlight
  • To make machine-learning analyses in the life sciences more computationally reproducible, we propose standards based on data, model and code publication, programming best practices and workflow automation. By meeting these standards, the community of researchers applying machine-learning methods in the life sciences can ensure that their analyses are worthy of trust.

    • Benjamin J. Heil
    • Michael M. Hoffman
    • Stephanie C. Hicks
    Comment
  • We present the AIMe registry, a community-driven reporting platform for AI in biomedicine. It aims to enhance the accessibility, reproducibility and usability of biomedical AI models, and allows future revisions by the community.

    • Julian Matschinske
    • Nicolas Alcaraz
    • David B. Blumenthal
    Comment
  • She connects equity, samurai swords, imaging and an automated way to count and track mitochondria.

    • Vivien Marx
    This Month
  • Researchers design DNA shells to trap virus particles and thus prevent interactions between viruses and host cells.

    • Lei Tang
    Research Highlight
  • A yeast cell culture approach mimics the benefits of somatic hypermutation to accelerate the discovery of desirable antibodies.

    • Katarzyna Marcinkiewicz
    Research Highlight
  • A neuroscientist who jams, plays and builds a way to capture animal movement.

    • Vivien Marx
    This Month
  • Professional editing can be a rewarding career. Here we discuss what the job entails, highs and lows, how to prepare for this career, the interview process and more.

    Editorial
  • Life scientists in Africa have had limited opportunity to participate in international advanced scientific training programs and workshops, which largely benefit researchers in North America, Europe and the Asia–Pacific region. Here, we chronicle the strategies adopted and challenges encountered in organizing Imaging Africa, an all-expenses-paid, continent-wide practical workshop in optical microscopy hosted in South Africa from 13 to 17 January 2020. Our experience can help steer other groups who similarly seek to organize impactful and sustainable training initiatives in Africa.

    • Michael A. Reiche
    • Digby F. Warner
    • Teng-Leong Chew
    Comment
  • I do not think you can start with anything precise. You have to achieve such precision as you can, as you go along. —Bertrand Russell

    • Naomi Altman
    • Martin Krzywinski
    This Month
  • DOME is a set of community-wide recommendations for reporting supervised machine learning–based analyses applied to biological studies. Broad adoption of these recommendations will help improve machine learning assessment and reproducibility.

    • Ian Walsh
    • Dmytro Fishman
    • Silvio C. E. Tosatto
    Comment