Collections

  • Special |

    The human reference genome is fundamental to basic, translational and clinical research.

    Image: Darryl Leja/NHGRI; Sequence map: Adam Novak/UCSC
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    Genome Engineering has great potential to change how we model, understand, and treat diseases.

    Image: XVIVO
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    How cells, tissues and organisms interpret the information encoded in the genome has vital implications for our understanding of development, health and disease. Launched in 2003, the ENCyclopedia of DNA Elements (ENCODE) project aims to map the functional elements in the human genome (later expanded to include model organisms).

    Image: StoryTK
  • Special |

    Our Method of the Year 2014 goes to light-sheet fluorescence microscopy. This series of papers discusses how this technology, in combination with increasingly sophisticated cameras and powerful computing, is dramatically changing and enabling the imaging of living biological samples from developing embryos to functioning brains. We also highlight methods worth watching in the upcoming years.

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    Nature Methods' choice for Method of the Year 2013 is single-cell sequencing. A collection of articles present the unique considerations related to sequencing single cells and highlight recent applications in biology and medicine. The Methods to Watch feature provides a look at possible future Methods of the Year.

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    Nature Methods' choice for Method of the Year 2012 is targeted proteomics. A collection of articles showcases how mass spectrometry technology is being developed and applied for targeted protein analysis in both basic and translational research.

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    Nature Methods' choice for Method of the Year 2011 is genome editing with engineered nucleases. This collection of articles—and the related video—highlights how the ability to use engineered nucleases to make precise, tailored and specific changes to coding and noncoding sequences of the genome, in cells and in organisms of many species, could revolutionize the study of gene function.

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    Autism spectrum disorder has attracted intense interest from the public and scientists over recent years. Nature sorts fact from fiction in this hot, but sometimes contentious, field: from the debate about soaring diagnoses, to the idea that scientists and engineers are at high risk of having a child with autism. The special includes news and comment fromNature, and articles fromNature Medicine,Nature NeuroscienceandNature Reviews Neuroscience.

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    We celebrate the 2011 International Year of Chemistry by highlighting the important contributions of chemistry to methods currently used in biology research. In a series of Commentaries, developers of chemistry-related tools and methods in three selected areas of research discuss their history and applications.

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    Nature Methods' choice of Method of the Year 2010 is optogenetics for its capacity to control cell function with light. A series of articles and a video describe how optogenetics has revolutionized the way experiments are conducted in neuroscience and showcase the potential the method has for the study of many signaling pathways in cell biology. The special feature also discusses how technological development will be needed to expand the possibilities of optogenetics.

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    Nature Methods' Method of the Year 2009 goes to induced pluripotency for its potential for biological discovery. This series of articles—and the related video—showcase how induced pluripotency is coming into its own in 2009 as a tool for discovery in both basic and disease biology and explore the incredible impact this area promises to have in biological research.

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    Nature Methods' Method of the Year 2008 goes to super-resolution fluorescence microscopy. This series of articles—and the related movie—showcase how these novel imaging methods came into their own in 2008 and the incredible impact they promise to have in biological research.