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This Focus issue features a series of papers offering guidelines and tools for improving the tracking and reporting of microscopy metadata with an emphasis on reproducibility and data re-use.
Image: Nilda Vanesa Ayala-Nunez (Institut de Recherche en Infectiologie à Montpellier), Orestis Faklaris (Montpellier Resources Imagerie, University of Montpellier), Caterina Strambio-De-Castillia (UMass Chan Medical School), Thao Do (Allen Institute of Cell Science)
Four years ago, the NIH’s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative Cell Census Network (BICCN) was launched, aiming to identify and catalog the diverse cells types in human, monkey and mouse brain.
Machine learning-based approaches are being increasingly applied in life sciences research. This series of articles propose community reporting standards, intended to help improve the reproducibility and useability of machine learning-based analyses.
In honor of the 50th anniversary of the Protein Data Bank, Nature Methods and Nature Structural & Molecular Biology present a collection that brings together reviews, classic papers, announcements and specially commissioned Comments by researchers from diverse areas of structural biology who share their views on both the past and future of the field.
Image: Illustration by David S. Goodsell, ‘THE MACHINERY OF LIFE’, published 2009 by Springer Nature.
This collection of primary research articles, reviews and protocols focuses on an emerging topic of mechanobiology, highlighting the broad involvement of mechanical forces in different biological contexts, their roles in development, physiology and disease, and how these forces are sensed and transduced to produce biologically-relevant responses. The collection also showcases new technical approaches to modulate mechanobiology, which in the future could be used to control cell fate and behaviour for therapeutic benefits.
How cells, tissues and organisms interpret the information encoded in the genome has vital implications for our understanding of development, health and disease. Launched in 2003, the ENCyclopedia of DNA Elements (ENCODE) project aims to map the functional elements in the human genome (later expanded to include model organisms).
New technologies to study stem cells have increased our knowledge about their physiological roles and contributions to development, ageing, regeneration and disease. This collection showcases research articles, reviews and protocols from across the Nature journals to highlight the striking advances made in basic and translational stem cell research.
Image: Benedetta Artegiani and Delilah Hendriks, Hubrecht Institute, Utrecht, The Netherlands.