Collections

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    One of the fundamental biological processes in life is the cell cycle leading from DNA replication to cell division. While it has been studied for decades and our knowledge has matured, sophisticated experimental approaches have rejuvenated the field. In addition, cell cycle regulators have emerged as cancer therapy targets. This collection showcases ground-breaking cell cycle papers and reviews, ranging from basic discoveries to clinical applications.

    Image: Nicolas Plachta, NCB (2022)
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    Research interest is growing in profiling noncoding RNAs and understanding their biological functions in health and disease contexts.

    Image: Jeren (France) / Getty Images
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    The 2022 Nobel Prize in Chemistry has been awarded to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for the development of click chemistry and bioorthogonal chemistry.

    Image: Springer Nature/The Nobel Foundation/Imagesource
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    The Telomere-to-Telomere (T2T) Consortium has generated the first complete human genome.

    Image: Guilio Formenti (The Rockefeller University) and Camilla Cima (freshmilk.it)
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    Recent technological progress has facilitated the study of how embryos develop, how embryonic cells transition between different states, how adult stem cells are maintained and differentiate, at unprecedented resolution.

    Image: Deepti L Kumar and Tony DeFalco
  • Focus |

    The COVID-19 pandemic has been marked by speedy scientific progress boosted by decades of methods development for basic biological research.

    Image: Kateryna Kon / Science Photo Library | Iren Moroz / Alamy Stock Photo
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    Genome Engineering has great potential to change how we model, understand, and treat diseases.

    Image: XVIVO
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    Protein structure prediction is our Method of the Year 2021, for the remarkable levels of accuracy achieved by deep learning-based methods in predicting the 3D structures of proteins and protein complexes, essentially solving this long-standing challenge.

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    This Focus issue features a series of papers offering guidelines and tools for improving the tracking and reporting of microscopy metadata with an emphasis on reproducibility and data re-use.

    Image: Nilda Vanesa Ayala-Nunez (Institut de Recherche en Infectiologie à Montpellier), Orestis Faklaris (Montpellier Resources Imagerie, University of Montpellier), Caterina Strambio-De-Castillia (UMass Chan Medical School), Thao Do (Allen Institute of Cell Science)
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    Four years ago, the NIH’s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative Cell Census Network (BICCN) was launched, aiming to identify and catalog the diverse cells types in human, monkey and mouse brain.

    Image: Jasiek Krzysztofiak/Nature
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    Machine learning-based approaches are being increasingly applied in life sciences research. This series of articles propose community reporting standards, intended to help improve the reproducibility and useability of machine learning-based analyses.

    Image: Weiquan Lin/Getty Images