Research Highlights

  • Research Highlights |

    CasRx is a programmable CRISPR–Cas system that targets RNA for efficient knockdown and splicing modulation.

    • Stéphane Larochelle
  • Research Highlights |

    A double-deletion rabies virus variant overcomes the cytotoxicity that has previously limited long-term applications for retrograde labeling of projection neurons.

    • Nina Vogt
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    A deep-learning-based approach improves the speed, accuracy, and robustness of biomedical image reconstruction.

    • Rita Strack
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    A combination of heat denaturation and mass spectrometry is applied to monitor protein-complex dynamics in the cell.

    • Allison Doerr
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    Upconversion nanoparticles can serve as intermediaries to illuminate optogenetic tools in the mouse brain.

    • Nina Vogt
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    SUSHI is a new method for imaging the extracellular space with high resolution in living brain tissue to reveal insights into the structure and dynamics of the extracellular space.

    • Christian Schnell
  • Research Highlights |

    How to make large synthetic gene libraries out of some beads, an oligo array and an emulsion.

    • Tal Nawy
  • Research Highlights |

    The combination of photoactivatable fluorescent markers with single-cell RNA-seq allows transcriptome analysis of cells from specific tissue locations.

    • Irene Jarchum
  • Research Highlights |

    SNP-CLING enables determining the dynamics of alleles on different chromosomes in live cells.

    • Nina Vogt
  • Research Highlights |

    Acoustic reporter genes that produce gas vesicles offer a way to image and locate microorganisms in mammalian hosts.

    • Christian Schnell
  • Research Highlights |

    A computational framework enables automated annotation, analysis, and sharing of mouse brain data at single-cell resolution.

    • Kate Gao
  • Research Highlights |

    Cellular engineering that allows budding yeast to survive with the four core human histones opens the door to exploring the function of histone variants and their modifications.

    • Nicole Rusk
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    Virus stamping can target single cells in complex tissues, both in culture and in vivo.

    • Nina Vogt
  • Research Highlights |

    Reflective coverslips can improve spatiotemporal resolution and collection efficiency in diSPIM light-sheet fluorescence microscopy.

    • Christian Schnell
  • Research Highlights |

    Building redundancy into fluorogenic sequencing makes for error-free DNA sequence reads.

    • Tal Nawy
  • Research Highlights |

    Using antibodies to target specific proteins for rapid degradation is a versatile approach for studying the function of endogenous proteins.

    • Ada Yee
  • Research Highlights |

    Trans-Tango allows trans-synaptic mapping of presynaptic and postsynaptic partners in Drosophila.

    • Nina Vogt
  • Research Highlights |

    Combining red calcium indicators with an optimized illumination strategy enables neuronal activity to be imaged in deep layers of the mouse cortex and hippocampus.

    • Nina Vogt
  • Research Highlights |

    Ultradeep sequencing of Hi-C data from mouse cells in different developmental stages can address outstanding questions about 3D chromatin function.

    • Nicole Rusk
  • Research Highlights |

    A class of semiconductor polymer particles can be used for afterglow imaging to avoid autofluorescence when imaging deep structures in living animals.

    • Christian Schnell
  • Research Highlights |

    A technique combining mass spectrometry and infrared spectroscopy shows promise for unambiguous sequencing of linear oligosaccharides.

    • Allison Doerr
  • Research Highlights |

    Protein evolution yields a programmable base editor that can revert the most common pathogenic point mutations in the genome.

    • Tal Nawy
  • Research Highlights |

    Ultralow concentrations of DNA can be optically sequenced with SMRT DNA sequencing.

    • Zachary J Lapin
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    Antibodies that initiate signaling cascades and thereby replace reprogramming factors promise an efficient and safe way to produce pluripotent stem cells.

    • Nicole Rusk
  • Research Highlights |

    An optical setup for observing targeted fluorophores lasing from within tissue.

    • Rita Strack
  • Research Highlights |

    A method to analyze intact glycopeptides on a proteome-wide scale almost doubles the number of confirmed glycoproteins.

    • Richard Pattison
  • Research Highlights |

    Image-guided targeting of fluorescently labeled neurons enables automated electrophysiological recordings of defined neuronal cell types.

    • Nina Vogt
  • Research Highlights |

    An integrated workflow allows the quantitative interrogation of the impact of alternative splicing at the proteome level.

    • Stéphane Larochelle
  • Research Highlights |

    A method to detect highly reactive lysine residues in the proteome helps spot those ripe for targeting by covalent ligands.

    • Allison Doerr
  • Research Highlights |

    A recombinase-based barcoding approach enables fate mapping in the hematopoietic system under physiological conditions.

    • Nina Vogt
  • Research Highlights |

    Single-particle reconstruction algorithms can be used to obtain 3D structures from 2D localization microscopy images.

    • Rita Strack
  • Research Highlights |

    DNA and chromatin structures can be visualized in situ with electron tomography.

    • Zachary J Lapin
  • Research Highlights |

    As more phage-derived Cas9 inhibitors are discovered, their detailed characterization is a prerequisite to using them as research tools.

    • Nicole Rusk
  • Research Highlights |

    Through scattering, in situ metal particle growth enables biomolecule visualization within tissue.

    • Zachary J Lapin
  • Research Highlights |

    An intermediate cell state of chemical reprogramming can be induced to convert directly between cell types.

    • Tal Nawy
  • Research Highlights |

    A self-inactivating rabies virus enables long-term tracing of neural networks without toxicity.

    • Irene Jarchum
  • Research Highlights |

    A large-scale approach to analyze how protein sequence determines folding provides new insights into an old question.

    • Allison Doerr
  • Research Highlights |

    Spontaneously blinking membrane probes enable live-cell super-resolution imaging for up to half an hour.

    • Rita Strack
  • Research Highlights |

    Developments in data-independent-acquisition mass spectrometry allow efficient and accurate quantitation of peptidoforms across large sample cohorts.

    • Stéphane Larochelle