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This Perspective offers an overview of organic dyes commonly used as fluorescent labels and gives a chemist’s insight into their benefits and peculiarities.
This Perspective describes advances in computer science that enable the integration of deep learning with traditional knowledge-based modeling in biological sciences, and discusses how such integration might overcome the challenges of modeling sparse, incomplete and noisy experimental data.
This Perspective, from a large group of metabolomics experts, provides best practices and simplified reporting guidelines for practitioners of liquid chromatography– and gas chromatography–mass spectrometry-based metabolomics.
Comprehensive guidelines and resources to enable accurate reporting for the most common fluorescence light microscopy modalities are reported with the goal of improving microscopy reporting, rigor and reproducibility.
This Perspective describes new single-molecule protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell proteomics.
This Perspective describes advances that have enabled robust directed evolution in mammalian cells. These approaches are poised to improve the development of new generations of tools to probe or modulate mammalian biology.