News & Views in 2012

Filter By:

Article Type
Year
  • A new toolbox for structural biology that combines single-molecule fluorescence and molecular modeling is used to generate high-precision structures of protein complexes.

    • Timothy D Craggs
    • Achillefs N Kapanidis
    News & Views
  • The Genome Multitool (GEM) mapper rapidly and accurately provides all alignments of a read within a user-defined number of mismatches.

    • Gregory G Faust
    • Ira M Hall
    News & Views
  • A new high-throughput method for monitoring G protein–coupled receptor activation is highly suited to assaying Gα12/13-coupled receptors and is used to deorphanize a group of receptors activated by lysophosphatidylserine.

    • Marc Parmentier
    News & Views
  • Two studies plant a signpost on the road toward a robust and detailed chromatin interaction map.

    • Xianghong Jasmine Zhou
    • Frank Alber
    News & Views
  • Through a collaborative effort, engineers and neuroscientists have created a method, using electrospun nanofibers as surrogate neuronal axons, to piece together the complexities of myelination.

    • Ragnhildur Thóra Káradóttir
    • John Henry Stockley
    News & Views
  • An experimental infrastructure consisting of environmentally controlled and spatially linked habitat patches permits studies on terrestrial animal dispersal at an unprecedented scale for an experiment with such strict control.

    • Nick M Haddad
    News & Views
  • In toto imaging of living embryos has now become much faster. Light-sheet illumination and fluorescence detection with four objective lenses provide complete coverage of large samples in a snap.

    • Michael Weber
    • Jan Huisken
    News & Views
  • A precomputed database of lineage-restricted reference genes yields a fast and accurate tool that uses sequence similarity alone to compute clade abundances from shotgun metagenomic data sets.

    • Daniel H Haft
    • Andrey Tovchigrechko
    News & Views
  • Researchers describe an approach to predict microbial-community composition across broad spatial and temporal gradients, an important step to bringing microbial ecology into the 21st century.

    • Noah Fierer
    • Joshua Ladau
    News & Views
  • Fluorescence recording of neural activity in the magnetic resonance scanner is a new strategy for examining the cellular underpinnings of blood oxygenation level–dependent (BOLD) functional magnetic resonance imaging (fMRI).

    • Serge Charpak
    • Bojana Stefanovic
    News & Views
  • Integrating biochemical footprinting data with molecular dynamics yields more accurate RNA three-dimensional structure predictions.

    • Reza Behrouzi
    • Sarah A Woodson
    News & Views
  • A strategy that uses genetically encoded GFP-tagged antibodies allows in vivo imaging of extracellular non–genetically encoded molecules.

    • Gauri Kulkarni
    • William G Wadsworth
    News & Views
  • Current practice for the generation and maintenance of induced pluripotent stem cells (iPSCs) involves static culture in dishes. Two groups now report that mouse iPSCs can be generated efficiently in stirred suspension culture.

    • Jiekai Chen
    • Duanqing Pei
    News & Views
  • Single-molecule DNA sequencing takes an important step in a surprising new direction with a sequence-detection method based on magnetic tweezers.

    • Sten Linnarsson
    News & Views
  • Deletion of a genomic locus may affect the function of neighboring loci, creating genetic uncertainty. Researchers now present a computational algorithm for identifying such neighboring-gene effects and improving the quality of functional annotations.

    • Anastasia Baryshnikova
    • Brenda Andrews
    News & Views