Method to Watch in 2010

The payoffs for efficient cargo delivery into living cells make the development of better methods worthwhile.

Targeted analysis of proteins on a broad scale with mass spectrometry is becoming a reality.

The use of adaptive optics to correct light distortions promises to greatly improve the imaging quality of thick biological tissues.

High-speed fluorescence imaging in all three dimensions at nanometer resolution will resolve, in finer detail, the workings of the living cell.

In 2011, we will see the arrival of new and improved sequencing technologies.

Genome-engineering tools with improved design and efficiency will become widely used.

X-ray free-electron lasers may enable single-molecule structure determination.

The application of systems approaches to human disease will continue to expand.