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This analysis systematically evaluates cross-linking chemistry and chromatin fragmentation strategies commonly used in 3C assays and introduces an improved Hi-C protocol for detecting loops and compartments.
Many computational tools for metagenomic profiling have been developed, with different algorithms and features. This analysis shows that, when comparing these tools, the distinction of different types of relative sequence abundance should be taken into consideration.
This Analysis reports a computational approach to implement Hi-C, SPRITE and GAM, which allows researchers to assess the performances of the three technologies to capture DNA contacts in chromatin three-dimensional models.
Results are presented from the first Critical Assessment of protein Intrinsic Disorder prediction (CAID) experiment, a community-based blind test to determine the state of the art in predicting intrinsically disordered regions in proteins.
A multi-laboratory study in the form of a community challenge assesses the quality of models that can be produced from cryo-EM maps using different software tools, the reproducibility of models generated by different users and the performance of metrics used for model validation.