Research Highlights

Researchers explore the unique and puzzling photostability of DNA FluoroCubes. Moreover, they improve the probes’ performance and highlight their diverse applicability.

Different nucleotides and derivatives can be read out by MspA-PBA, an engineered nanopore.

A method to develop gastrulating embryoids from stem cells ex utero.

The NeuroCAAS platform simplifies data analysis in the neuroscience space for users and enhances reproducibility.

plexDIA increases throughput of proteomics analysis with low sample amounts.

Researchers describe Retro-Cascorder, a tool that employs prokaryotic retrons and CRISPR integrases to write transcriptional events into the genome of Escherichia coli.

VASA-seq offers a single cell sequencing tool for capturing full-length coverage of coding sequences and supplementing non-coding RNA molecules.

Researchers have discovered two naturally occurring channelrhodopsins for potassium ion transport that can be used in optogenetic applications.

Stem cell-derived endothelial cell subtypes enable study of viral tropism.

Imputing missing parental genotypes sharpens estimates of direct genetic effects.

FlipFlop mice harbor functionally reversed T cells due to a switch in CD4 and CD8 expression.

Researchers repurpose cytosine deaminase toxin DddA to measure DNA–protein interaction sites in bacteria.

Machine learning decodes the hidden rules of enhancers.

Deep Visual Proteomics combines the power of deep-learning-based image analysis with microdissection and ultrasensitive mass spectrometry to provide insights into the spatial proteome.

A newly described fluorescent protein, StayGold, is bright and extremely photostable, enabling extended time-lapse imaging.

TALE-fused deaminases enable C-to-T or A-to-G base editing in human mitochondria.

A coarse-grained model enables simulating droplet formation with low-complexity RNA sequences.

To recapitulate some of the complexities of the human physiology, engineered tissues can be linked by vascular flow in a multi-organ chip.