Research Highlights

Functional ultrasound imaging enables unbiased identification of behaviorally relevant brain regions across the whole brain.

A protein nanopore sensor detects transient protein–protein interactions at single-molecule resolution.

A three-component system of epigenetic writers and readers preserves memory over many generations of cells.

Researchers have developed two optogenetic tools for probing and controlling phase separation in living cells.

Researchers have developed the first fully genetically encodable eukaryotic bioluminescent system.

Synthetic small molecules can form liquid-phase condensates and simultaneously sequester intracellular enzymes.

A new development in high-speed atomic force microscopy enables microsecond resolution.

A vesicle-based mass spectrometry method enables the analysis of protein complexes in native membranes.

A macroscope mounted on the head of a freely moving transgenic rat can help shine light on complex behaviors.

A machine learning model predicts the genotype of CRISPR–Cas9 gene editing products, thereby enabling precise, template-free correction of disease-associated mutations.

Adaptive light-sheet microscopy enables imaging of mouse development through early organogenesis with single-cell resolution.

Flipping opsins within the membrane diversifies the array of available optogenetics tools.

Acquisition of RNA into CRISPR arrays allows the recording of transcriptional dynamics in cells.

A new computational method integrates RNA single-cell sequencing and spatial data.

The concept of massively parallel single-molecule protein sequencing emerges.

Dip-C, a descendent of the 3C method, reveals 3D genome structures of single diploid human cells.

Deep learning pushes the limits of accuracy in genomic variant calling.

Researchers have carried out the first de novo design of a β-barrel protein and engineered the interior to bind and activate a fluorogenic dye.

The European XFEL produces its first protein structures.

Phage biology yields useful anti-CRISPR proteins that may also lead to new CRISPR systems.