Research Highlights

Engineering human centromeres will allow versatile applications.

BODIPY dimerization is exploited for super-resolution imaging and single-particle tracking of lipids in living cells.

T-scan allows discovery of epitopes that define T-cell-based immunity.

A DNA origami rotor amplifies and tracks DNA movements during biochemical reactions, uncovering action mechanisms of genome-processing enzymes.

Tagging and sequencing RNAs that are in close spatial proximity in the nucleus shows how the transcriptome is partitioned.

An improved method to detect coevolving residues at protein interfaces allows proteome-wide screening of PPIs.

The development of biologically compatible microdisk lasers enables massively multiplexed cell tracking.

Single-cell sequencing of Hydra results in a resource for studying differentiation trajectories, regeneration and nervous system development.

Illuminating the brain for optogenetic experiments can have undesirable effects on neural activity.

The concept of reference frames inspires researchers to develop a differential ranking system for measuring relative differential abundance, which does not require information about absolute microbial load.

A newly developed method allows structure elucidation of proteins inside intact mammalian cells, using solid-state NMR spectroscopy.

A humanized version of the RNA-targeting Cas13 can regulate RNA abundance and translation.

DNA microscopy is an optics-free method for encoding physical images in DNA.

Multicolor calcium indicators pave the way to a better understanding of information processing in the brain.

Blocking the active sites of proteins with a photocaged tyrosine allows for temporally precise photoactivation of a wide range of proteins of interest.

Developments in genetically encoded voltage indicators and imaging strategies enable the recording of multiple neurons with good signal-to-noise ratios in behaving mice.

A library of degrons allows tuning of half-life and expression levels of proteins in genetic circuits.

A global-scale survey of the ocean viral metagenome (virome) broadens views on marine viruses and their roles in ecosystems.

Phase separation in combination with spatial targeting allows for selective translation of mRNA within synthetic membraneless organelles.

An improved sequential fluorescence in situ hybridization approach allows one to image the expression of 10,000 genes in single cells.