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Directly or indirectly, most cell biologists study cell signaling, a field whose complexity has grown geometrically with recent advances in molecular biology. Combining refinements of older techniques with innovative new methods can help researchers traverse this rapidly expanding field. Alan Dove reports.
Intracellular protein-protein interactions form the basis of most biological processes. Structural aspects of these reactions can now be analyzed in living prokaryotic cells and in atomic detail by nuclear magnetic resonance spectroscopy.