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A method of time-resolved two-photon volume imaging with cellular resolution allows for the first time a comprehensive analysis of cortical microcircuits in vivo.
A new maximum likelihood–based algorithm allows cryo-EM structure determination of macromolecular complexes even when conformational heterogeneity is present.
ProteomeBinders is a new European consortium aiming to establish a comprehensive resource of well-characterized affinity reagents, including but not limited to antibodies, for analysis of the human proteome. Given the huge diversity of the proteome, the scale of the project is potentially immense but nevertheless feasible in the context of a pan-European or even worldwide coordination. NOTE: In the version of the article originally published, Manfred Koegl’s name was misspelled. Additionally, Zoltan Konthur's affiliation was listed incorrectly; it should be Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany. These errors have been corrected in the HTML and PDF versions of the article.
Advances in crystallographic methods, the rise of nuclear magnetic resonance, and the blossoming of global structural genomics initiatives have helped to fuel a renaissance in the development of methods for high-resolution protein structural biology. Michael Eisenstein reports.