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Cytoself is a self-supervised deep learning-based approach for profiling and clustering protein localization from fluorescence images. Cytoself outperforms established approaches and can accurately predict protein subcellular localization.
Recombinant adeno-associated virus tools for enhanced microglial transduction in mice are reported. These viruses can be used to express functional reporters or genome editing tools with high microglial specificity, with the help of microglia-specific Cre lines.
The Integrative Genome Modeling (IGM) platform incorporates information from multiple, complementary experimental data sources to accurately simulate whole diploid genome structures. We show that such structures have high predictive power and give access to a large variety of structural observables for the characterization of the gene microenvironment.
RAPToR (real age prediction from transcriptome staging on reference) is a new, broadly applicable method that can precisely estimate the age of a sample from a reference transcriptome time series.
The Integrative Genome Modeling platform is a tool for population-based three-dimensional genome structure modeling and analysis by integrating various experimental data sources.
Real age prediction from transcriptome staging on reference (RAPToR) precisely estimates the real age of a specimen on the basis of transcriptomic data. RAPToR is broadly applicable and can be used to remove age as a confounding variable.
Deep Visual Proteomics combines the power of deep-learning-based image analysis with microdissection and ultrasensitive mass spectrometry to provide insights into the spatial proteome.
This study demonstrates the feasibility of generating near-finished microbial genomes using only Oxford Nanopore R10.4 data from pure cultures or metagenomes.
A diagnostic fragment ion in tandem mass spectrometry enables confident protein lactylation assignment and the discovery of broad lysine modification beyond histones.
This article reports the cyclic immonium ion as a diagnostic fragment ion for lysine lactylation. The approach was used for identifying lactylation in various enriched and unenriched proteome databases, demonstrating prevalence of lactylation beyond histones.
