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  • The DAQ score assesses the consistency of amino acid assignment in protein structure models with local density from cryo-EM maps. The method complements existing quality metrics and is a versatile tool for highlighting problematic regions of model structures.

    • Genki Terashi
    • Xiao Wang
    • Daisuke Kihara
    Article
  • PROBER is a fast and sensitive episome-based method to identify sequence-specific DNA-binding proteins from living cells using proximity proteomics. This method quantifies steady-state and inducible association of transcription factors and corresponding chromatin regulators to specific DNA sequences as well as binding quantitative trait loci present as a result of single nucleotide variants.

    Research Briefing
  • Researchers have discovered two naturally occurring channelrhodopsins for potassium ion transport that can be used in optogenetic applications.

    • Rita Strack
    Research Highlight
  • Stem cell-derived endothelial cell subtypes enable study of viral tropism.

    • Madhura Mukhopadhyay
    Research Highlight
  • In this issue, we are delighted to launch a new regular feature: the Creature Column.

    Editorial
  • Imputing missing parental genotypes sharpens estimates of direct genetic effects.

    • Lin Tang
    Research Highlight
  • Tardigrades are everywhere. They’re tiny — usually under a millimeter long — and they’re mostly transparent, so they’re easy to miss. But you probably walk by them every day. We’ve been grooming them as emerging models for studying how body forms evolve and how biological materials can survive extreme conditions.

    • Bob Goldstein
    This Month
  • Dipole–dipole crosstalk between fluorophores separated by a distance of less than 10 nm induces changes in their photophysics, which adds a challenge to localization microscopy in the sub-10-nm regime.

    • Karim Almahayni
    • Malte Spiekermann
    • Leonhard Möckl
    News & Views
  • Energy transfer between fluorophores is shown to impede SMLM at sub-10-nm spatial resolution. Time-resolved detection and photoswitching fingerprinting analysis are used to determine the number and separation of closely spaced fluorophores.

    • Dominic A. Helmerich
    • Gerti Beliu
    • Markus Sauer
    Article Open Access
  • Expeditions are delivering data wealth about our planet’s oceans, including its microbes. Some labs are now diving deep into the ocean virome.

    • Vivien Marx
    Technology Feature
  • Even without a stint on an ocean-faring vessel, scientists can trawl through data to explore marine viruses and address new puzzles and cultural shifts.

    • Vivien Marx
    Technology Feature
  • The study of human–animal chimeras is fraught with technical and ethical challenges. In this Comment, we discuss the importance and future of human–monkey chimera research within the context of current scientific and regulatory obstacles.

    • Alejandro De Los Angeles
    • Alan Regenberg
    • Elias T. Zambidis
    Comment