• Confetti conceptually illustrates the broad diversity of noncoding RNAs

    Research interest is growing in profiling noncoding RNAs and understanding their biological functions in health and disease contexts. The articles featured in this collection highlight recent method developments and key resources that enable researchers to further explore the noncoding RNA field.

  • Virus particle

    The COVID-19 pandemic has been marked by speedy scientific progress boosted by decades of methods development for basic biological research. Here, we highlight some of the key advancements that have facilitated the scientific response to SARS-CoV-2.

  • Complete human genome

    The Telomere-to-Telomere (T2T) Consortium has generated the first complete human genome. Some of the methods and results from the consortium are presented here along with expert commentary on this milestone.

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  • Dramatic advances in protein structure prediction have sparked debate as to whether the problem of predicting structure from sequence is solved or not. Here, I argue that AlphaFold2 and its peers are currently limited by the fact that they predict only a single structure, instead of a structural distribution, and that this realization is crucial for the next generation of structure prediction algorithms.

    • Thomas J. Lane
  • Mechanoimmunology methods help dissect the mechanical forces within the immune system.

    • Madhura Mukhopadhyay
    Method to Watch
  • CRISPR systems can be leveraged to direct recombinases to integrate gene-sized DNA sequences.

    • Lei Tang
    Method to Watch
  • Strategies to overcome poor reproducibility in MRI studies are needed.

    • Nina Vogt
    Method to Watch
  • In vitro models and single-cell atlases help uncover the mysteries of human embryogenesis.

    • Madhura Mukhopadhyay
    Method to Watch

Method of the Year 2021: Protein structure prediction

Protein structure prediction is our Method of the Year 2021, for the remarkable levels of accuracy achieved by deep learning-based methods in predicting the 3D structures of proteins and protein complexes, essentially solving this long-standing challenge.


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