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  • fluorescent embryos

    Methods for modeling development is our Method of the Year 2023, for the remarkable insights that recent methodological advances have enabled in our understanding of the molecular mechanisms of human embryogenesis.

  • Conference banner

    Advances in electron microscopy have spurred progress in the physical and life sciences. The 3rd Frontiers in Electron Microscopy for Physical and Life Sciences will bring together researchers working on cutting-edge electron microscopy technologies, with an emphasis on identifying and addressing new challenges, promoting synergies and developing the next generation of instruments and tools.

  • a plant and a keyboard

    We are looking to expand our journal scope to include more ecology papers, particularly those describing methods for quantitative analysis of ecological and evolutionary data. Published papers will be added to this Collection.

    Open for submissions

Nature Methods is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.

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  • PINNACLE is a context-specific geometric deep learning model for generating protein representations. Leveraging single-cell transcriptomics combined with networks of protein–protein interactions, cell type-to-cell type interactions and a tissue hierarchy, PINNACLE generates high-resolution protein representations tailored to each cell type.

    • Michelle M. Li
    • Yepeng Huang
    • Marinka Zitnik
    ArticleOpen Access
  • Bayesian nonparametric Track (BNP-Track) simultaneously determines emitter numbers and their tracks alongside uncertainty, extending the superresolution paradigm from static samples to single-particle tracking even in dense environments.

    • Ioannis Sgouralis
    • Lance W. Q. Xu
    • Steve Pressé
    ArticleOpen Access
  • Onavg is a surface template of the human cortex. In contrast to existing templates, the cortical surface is uniformly sampled, which has advantages in numerous applications.

    • Ma Feilong
    • Guo Jiahui
    • James V. Haxby
    ArticleOpen Access
  • SwitchSeeker combines computational and experimental techniques to identify functional RNA structural switches. Applied to the human transcriptome, it identified a novel RNA switch in the 3ʹUTR of RORC, linked to nonsense-mediated decay.

    • Matvei Khoroshkin
    • Daniel Asarnow
    • Hani Goodarzi
    ArticleOpen Access
  • Bats, the only flying mammals, comprise almost 25% of mammalian species. They are excellent navigators, highly social, and extremely long-lived. Their sense of echolocation has been studied for many years — but many species possess also excellent vision and olfaction. In recent years, bats have emerged as new models for neurobiology of navigation, social neuroscience, aging, and immunity.

    • Liora Las
    • Nachum Ulanovsky
    This Month
  • Tissues and organs are inherently three-dimensional. Studies to understand their function and dysfunction should therefore aim to maintain the 3D spatial context.

    Editorial
  • Machine learning approaches can distinguish six different classes of presynapses from electron micrographs across the Drosophila brain.

    • Rita Strack
    Research Highlight
fluorescently labeled mouse blastocysts

Method of the Year 2023: Methods for modeling development

Methods for modeling development is our Method of the Year 2023, for the remarkable insights that recent methodological advances have enabled in our understanding of the molecular mechanisms of human embryogenesis.
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