• Virus particle

    The COVID-19 pandemic has been marked by speedy scientific progress boosted by decades of methods development for basic biological research. Here, we highlight some of the key advancements that have facilitated the scientific response to SARS-CoV-2.

  • Complete human genome

    The Telomere-to-Telomere (T2T) Consortium has generated the first complete human genome. Some of the methods and results from the consortium are presented here along with expert commentary on this milestone.

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  • This paper proposes two new anisotropy metrics—the Fourier shell occupancy and the Bingham test—that can be used to understand the quality of cryogenic electron microscopy maps.

    • Jose-Luis Vilas
    • Hemant D. Tagare
    Brief Communication
  • SIMBA learns a co-embedding space of single cells and multiple features such as genes, chromatin-accessible regions and transcription-factor-binding sequences, boosting the performances of various analyses of cellular diversity and regulation.

    • Huidong Chen
    • Jayoung Ryu
    • Luca Pinello
    ArticleOpen Access
  • The miniature RNA-guided endonuclease IscB and its ωRNA were engineered for efficient gene editing in mammalian cells. Fusions of ‘enIscB’ to T5 exonuclease and cytosine or adenosine deaminase yield versatile tools for genome engineering.

    • Dingyi Han
    • Qingquan Xiao
    • Yingsi Zhou
  • This updated analysis of the Cell Tracking Challenge explores how algorithms for cell segmentation and tracking in both 2D and 3D have advanced in recent years, pointing users to high-performing tools and developers to open challenges.

    • Martin Maška
    • Vladimír Ulman
    • Carlos Ortiz-de-Solórzano
    AnalysisOpen Access

Method of the Year 2021: Protein structure prediction

Protein structure prediction is our Method of the Year 2021, for the remarkable levels of accuracy achieved by deep learning-based methods in predicting the 3D structures of proteins and protein complexes, essentially solving this long-standing challenge.


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