• Virus particle

    The COVID-19 pandemic has been marked by speedy scientific progress boosted by decades of methods development for basic biological research. Here, we highlight some of the key advancements that have facilitated the scientific response to SARS-CoV-2.

  • Abstract image

    The 2nd Frontiers in Electron Microscopy for Physical and Life Sciences will take place at Princeton University on September 28-30, 2022. Join researchers across physical and life sciences, plus editors from Nature Methods, Nature, Nature Materials and Nature Communications, to discuss cutting-edge technology developments in this field.

Nature Methods is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


  • Cameras are a crucial part of microscopes and are also built into many kinds of instruments. To make their output comparable takes standards.

    • Vivien Marx
    Technology Feature
  • A newly described fluorescent protein, StayGold, is bright and extremely photostable, enabling extended time-lapse imaging.

    • Rita Strack
    Research Highlight
  • To recapitulate some of the complexities of the human physiology, engineered tissues can be linked by vascular flow in a multi-organ chip.

    • Nina Vogt
    Research Highlight

Method of the Year 2021: Protein structure prediction

Protein structure prediction is our Method of the Year 2021, for the remarkable levels of accuracy achieved by deep learning-based methods in predicting the 3D structures of proteins and protein complexes, essentially solving this long-standing challenge.


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