Image: Daniel Castranova, Brant Weinstein & Bakary Samasa. Cover Design: Erin Dewalt.

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Latest Research

  • Article |

    A computational tool, Avant-garde, automates refinement of data-independent acquisition mass spectrometry-based quantitative proteomics data.

    • Alvaro Sebastian Vaca Jacome
    • , Ryan Peckner
    • , Nicholas Shulman
    • , Karsten Krug
    • , Katherine C. DeRuff
    • , Adam Officer
    • , Karen E. Christianson
    • , Brendan MacLean
    • , Michael J. MacCoss
    • , Steven A. Carr
    •  & Jacob D. Jaffe
  • Article |

    Engineered deubiquitinases (enDUBs) use nanobodies to bring deubiquitinases to target proteins for selective ubiquitin chain removal. enDUBs can rescue the functional expression of mutant ion channels like those responsible for cystic fibrosis.

    • Scott A. Kanner
    • , Zunaira Shuja
    • , Papiya Choudhury
    • , Ananya Jain
    •  & Henry M. Colecraft
  • Article |

    Simultaneous widefield calcium imaging and fMRI provide insight into neural activity at multiple scales and can be used to decipher the cellular origin of BOLD activity.

    • Evelyn M. R. Lake
    • , Xinxin Ge
    • , Xilin Shen
    • , Peter Herman
    • , Fahmeed Hyder
    • , Jessica A. Cardin
    • , Michael J. Higley
    • , Dustin Scheinost
    • , Xenophon Papademetris
    • , Michael C. Crair
    •  & R. Todd Constable
  • Article |

    O-Pair search identifies O-glycopeptides and localizes O-glycosites using a fragment-ion-indexed open modification search combined with a graph-based approach. It also introduces a classification scheme to unify data reporting for glycoproteomics.

    • Lei Lu
    • , Nicholas M. Riley
    • , Michael R. Shortreed
    • , Carolyn R. Bertozzi
    •  & Lloyd M. Smith
  • Article |

    Red and improved green versions of the genetically encoded dopamine sensor GRABDA have been developed. These neurotransmitter sensors are used alone or in combination with, for example, calcium sensors in behaving fruit flies and rodents.

    • Fangmiao Sun
    • , Jingheng Zhou
    • , Bing Dai
    • , Tongrui Qian
    • , Jianzhi Zeng
    • , Xuelin Li
    • , Yizhou Zhuo
    • , Yajun Zhang
    • , Yipan Wang
    • , Cheng Qian
    • , Ke Tan
    • , Jiesi Feng
    • , Hui Dong
    • , Dayu Lin
    • , Guohong Cui
    •  & Yulong Li

News & Comment

Collection

Expanding the CRISPR Toolbox

The CRISPR-Cas9 system is best known for its ability to knock out or replace specific genes, via targeted cleavage of the genome. But scientists are developing many more applications, typically by using an inactive Cas9 to target other enzymes to specific genomic sites. From transcriptional regulation to base editing, these developments are extending the range of biological questions that can be probed with CRISPR/Cas9.

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