Exosome detection via the ultrafast-isolation system: EXODUS

  • Yuchao Chen
  • Qingfu Zhu
  • Fei Liu

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  • Beyond the well-known pantheon of model organisms are others. A shift is underway to level the playing field.

    • Vivien Marx
    Technology Feature
  • Global protein structure readouts help detect protein functional changes.

    • Arunima Singh
    Research Highlight
  • DeepLabCut-Live! performs pose estimation in real time and allows closed-loop feedback on behavior.

    • Nina Vogt
    Research Highlight
  • Loop-seq is a high-throughput sequencing assay that measures DNA looping and can help explain how DNA bendability contributes to nucleosome organization.

    • Lei Tang
    Research Highlight
  • DNA-PAINT with left-handed DNA oligomers enables imaging of nuclear structures with reduced background.

    • Rita Strack
    Research Highlight
  • New year, big changes: Nature Methods now offers authors the ability to publish research papers on an open access basis, including via a Guided Open Access pilot. Here’s how it works.

Expanding the CRISPR Toolbox

Expanding the CRISPR Toolbox

The CRISPR-Cas9 system is best known for its ability to knock out or replace specific genes, via targeted cleavage of the genome. But scientists are developing many more applications, typically by using an inactive Cas9 to target other enzymes to specific genomic sites. From transcriptional regulation to base editing, these developments are extending the range of biological questions that can be probed with CRISPR/Cas9.

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