Volume 17 Issue 6, June 2018

Volume 17 Issue 6

Harnessing the immune system

Immunotherapy offers a promising approach to treating a range of complications. This Review discusses strategies that employ bioengineering and immunological principles to develop engineered tissues for screening therapeutics and treating diseases.

See Gosselin et al.

Image: Copyright 2018, Fairman Studios, LLC. Concept: Jennifer E. Fairman, CMI, FAMI and Chris Jewell, PhD. Cover Design: David Shand.

Editorial

  • Editorial |

    As the interaction of the immune system with the tumour microenvironment becomes increasingly understood, more evidence indicates how immunotherapy can be employed to better eliminate cancers.

    Focus:

Feature

  • Feature |

    Darrell Irvine provides an overview of the recent advances in materials science that have enabled the use of innovative natural and synthetic compounds in vaccine development capable of regulating the potency and safety of new vaccines progressing towards the clinic.

    • Darrell Irvine

    Focus:

  • Feature |

    Camille M. Le Gall, Jorieke Weiden, Loek J. Eggermont and Carl G. Figdor provide an overview of immunotherapeutics for cancer treatment that harness dendritic cells, their challenges in clinical use, and approaches employed to enhance their recruitment and activation to promote effective anti-tumour immunity.

    • Camille M. Le Gall
    • , Jorieke Weiden
    • , Loek J. Eggermont
    •  & Carl G. Figdor

    Focus:

  • Feature |

    Tumour heterogeneity and off-target toxicity are current challenges of cancer immunotherapy. Karine Dzhandzhugazyan, Per Guldberg and Alexei Kirkin discuss how epigenetic induction of tumour antigens in antigen-presenting cells may form the basis for multi-target therapies.

    • Karine N. Dzhandzhugazyan
    • , Per Guldberg
    •  & Alexei F. Kirkin

    Focus:

News & Views

  • News & Views |

    Spin currents in magnetic trilayers exhibit an unexpected spin polarization that facilitates current-induced switching of magnetization.

    • Frank Freimuth
  • News & Views |

    By using high-concentration salt in electrolyte, water is replaced in the zinc solvation-sheath and a zinc anode is developed with high reversibility and stability

    • Enyuan Hu
    •  & Xiao-Qing Yang
  • News & Views |

    A strategy to enhance antigen immunogenicity was developed by adsorption of polyethyleneimine on a mesoporous silica microrod vaccine for the presentation of tumour viruses and neoantigens, demonstrating their ability to drive anti-tumour immunity.

    • Cornelis J. M. Melief

    Focus:

Review Articles

  • Review Article |

    Immunotherapy offers a promising approach to treating a range of complications. This Review discusses strategies that employ bioengineering and immunological principles to develop engineered tissues for screening therapeutics and treating diseases.

    • Emily A. Gosselin
    • , Haleigh B. Eppler
    • , Jonathan S. Bromberg
    •  & Christopher M. Jewell

    Focus:

Letters

  • Letter |

    Tunnelling spectroscopy reveals a continuous closing of the superconducting gap at low temperature and high in-plane magnetic field in few-layer NbSe2, due to the Ising spin–orbit coupling of these materials.

    • Egon Sohn
    • , Xiaoxiang Xi
    • , Wen-Yu He
    • , Shengwei Jiang
    • , Zefang Wang
    • , Kaifei Kang
    • , Ju-Hyun Park
    • , Helmuth Berger
    • , László Forró
    • , Kam Tuen Law
    • , Jie Shan
    •  & Kin Fai Mak
  • Letter |

    Spin–orbit torques are reported in ferromagnetic trilayers that lead to the switching of perpendicular magnetizations without an external magnetic field.

    • Seung-heon C. Baek
    • , Vivek P. Amin
    • , Young-Wan Oh
    • , Gyungchoon Go
    • , Seung-Jae Lee
    • , Geun-Hee Lee
    • , Kab-Jin Kim
    • , M. D. Stiles
    • , Byong-Guk Park
    •  & Kyung-Jin Lee
  • Letter |

    In situ transmission electron microscopy observations reveal atomistic mechanism of water-vapour-enhanced oxidation of Ni–Cr alloys. Protons derived from water promote vacancy formation, migration and clustering.

    • Langli Luo
    • , Mao Su
    • , Pengfei Yan
    • , Lianfeng Zou
    • , Daniel K. Schreiber
    • , Donald R. Baer
    • , Zihua Zhu
    • , Guangwen Zhou
    • , Yanting Wang
    • , Stephen M. Bruemmer
    • , Zhijie Xu
    •  & Chongmin Wang
  • Letter |

    Electron microscopy and modelling are used to study CO oxidation on oxide-supported Pd. The perimeter of the metal/oxide interface is shown to affect CO tolerance of the entire particle, demonstrating a long-range effect over micrometre length scales.

    • Yuri Suchorski
    • , Sergey M. Kozlov
    • , Ivan Bespalov
    • , Martin Datler
    • , Diana Vogel
    • , Zuzana Budinska
    • , Konstantin M. Neyman
    •  & Günther Rupprechter
  • Letter |

    Active rotational motion of pre-strained materials is achieved by elastic deformations that break rotational symmetry around their axes.

    • Arthur Baumann
    • , Antoni Sánchez-Ferrer
    • , Leandro Jacomine
    • , Philippe Martinoty
    • , Vincent Le Houerou
    • , Falko Ziebert
    •  & Igor M. Kulić
  • Letter |

    A strategy to enhance antigen immunogenicity is shown using polyethyleneimine adsorbed on mesoporous silica microrod vaccine as a platform for neoantigens, supporting potent humoral immune response and inhibition of tumour growth following vaccination.

    • Aileen Weiwei Li
    • , Miguel C. Sobral
    • , Soumya Badrinath
    • , Youngjin Choi
    • , Amanda Graveline
    • , Alexander G. Stafford
    • , James C. Weaver
    • , Maxence O. Dellacherie
    • , Ting-Yu Shih
    • , Omar A. Ali
    • , Jaeyun Kim
    • , Kai W. Wucherpfennig
    •  & David J. Mooney

    Focus:

Articles

  • Article |

    Monolayer MoS2 can be laterally grown in the vapour–liquid–solid mode, forming highly crystalline nano- and microribbon structures.

    • Shisheng Li
    • , Yung-Chang Lin
    • , Wen Zhao
    • , Jing Wu
    • , Zhuo Wang
    • , Zehua Hu
    • , Youde Shen
    • , Dai-Ming Tang
    • , Junyong Wang
    • , Qi Zhang
    • , Hai Zhu
    • , Leiqiang Chu
    • , Weijie Zhao
    • , Chang Liu
    • , Zhipei Sun
    • , Takaaki Taniguchi
    • , Minoru Osada
    • , Wei Chen
    • , Qing-Hua Xu
    • , Andrew Thye Shen Wee
    • , Kazu Suenaga
    • , Feng Ding
    •  & Goki Eda
  • Article |

    Metallic zinc is an ideal anode material for aqueous batteries but suffers from irreversibility issues. An aqueous electrolyte based on Zn and lithium salts using either LiMn2O4 or O2 cathodes now brings unprecedented flexibility and reversibility to Zn batteries.

    • Fei Wang
    • , Oleg Borodin
    • , Tao Gao
    • , Xiulin Fan
    • , Wei Sun
    • , Fudong Han
    • , Antonio Faraone
    • , Joseph A Dura
    • , Kang Xu
    •  & Chunsheng Wang
  • Article |

    Films of exfoliated crystals of two-dimensional hybrid metal halide perovskites with phenyl groups as organic cations show increased molecular rigidity, reduced electron–phonon interactions and blue emission with photoluminescence quantum yield approaching 80%.

    • Xiwen Gong
    • , Oleksandr Voznyy
    • , Ankit Jain
    • , Wenjia Liu
    • , Randy Sabatini
    • , Zachary Piontkowski
    • , Grant Walters
    • , Golam Bappi
    • , Sergiy Nokhrin
    • , Oleksandr Bushuyev
    • , Mingjian Yuan
    • , Riccardo Comin
    • , David McCamant
    • , Shana O. Kelley
    •  & Edward H. Sargent
  • Article |

    Quantitative analysis of polymer LED degradation under current stress provides insight on the role of hole traps and their formation. Blending of the emitting material with large-bandgap semiconductors leads to trap dilution and improved stability.

    • Quan Niu
    • , Roland Rohloff
    • , Gert-Jan A. H. Wetzelaer
    • , Paul W. M. Blom
    •  & N. Irina Crăciun

Amendments & Corrections