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Post-infusion poly(ethylene glycol) surface modification of chimeric antigen receptor (CAR)-engineered T cells and a subcutaneous chemokine-adsorbing hydrogel address cytokine release syndrome and the neurotoxicity side effects of CAR T cell therapy against tumours.
Polymers made by click chemistry with spirocyclic building blocks form membranes that separate the components of crude oil based on molecular size and type, potentially using far less energy than distillation. Key enablers of this separation are moderate levels of polymer dynamic motion and frustrated chain packing.
A compact, time- and energy-efficient computing architecture — based on ferroelectric-defined reconfigurable two-dimensional photodiode arrays — is shown to be capable of in-memory sensing and computing.
Hybridized electron or hole states across semiconducting van der Waals monolayers in heterotrilayer systems enable the emergence of quadrupolar excitons. Quadrupolar excitons, unlike their dipolar counterparts, have a tunable static dipole moment that responds nonlinearly under an applied electric field.
The discovery of passivating agents for perovskite photovoltaics can be an arduous and time-consuming process. Now, a machine-learning model is reported that accelerates the selection of bifunctional pseudo-halide passivators. The identified pseudo-halide passivators were experimentally shown to enhance the performance of perovskite solar cells.
Heat treatment can transform some moiré superlattices into fully commensurate bilayers, where atoms in opposite layers align perfectly with each other. This structural transformation gives rise to markedly brighter interlayer excitons.
By inserting an epitaxial in-plane buffer layer of Bi5FeTi3O15, an artificial flux closure architecture enables ferroelectric polarization from a single unit cell of BaTiO3 or BiFeO3.
Three protein interaction surfaces are computationally designed into one protein subunit to enable their accurate assembly into three-dimensional crystals with user-specified lattice architectures.
A traditional physical-reservoir device has limited flexibility and cannot perform well across a range of computing tasks, owing to the fixed reservoir properties of the physical system. However, by exploiting the rich magnetic phase spaces of a single chiral magnet, reservoir properties can be reconfigured. This control enables on-demand optimization of computational performance across diverse machine-learning tasks.
Chiral single-photon emitters are desirable, versatile tools for quantum information processing. Exploiting proximity to a strain-induced local magnetic field in the van der Waals antiferromagnet NiPS3 enables the emission of high-purity chiral single photons from monolayer WSe2 at zero external magnetic field.
An approach to analyse the deformation behaviour of polymer networks provides an enhanced set of structural information, improving our understanding of the elasticity of soft materials.
Terahertz photoconductivity measurements coupled with theoretical modelling reveals that thermal transient excitations to more delocalized states enhances hole mobility in organic molecular semiconductors.
Lymphatic vessels within and near to tumours facilitate nanoparticle transport out of tumours, with ramifications in the design and implementation of next-generation clinical cancer nanomedicines.
