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RNA-based therapeutics hold promise for the treatment of several diseases. This Review provides an overview of hydrogels for RNA delivery, discussing how the chemical nature and physical properties of hydrogels can be explored for tailored RNA loading and release, and highlighting the use of these materials in biomedical applications.
A bioengineered model incorporating a synthetic extracellular matrix recapitulates the lymphoid tumour microenvironment, making it a valuable tool for drug testing and designing personalized therapies.
Vibrational spectroscopy now allows for the exploration of lattice vibrational properties at the chemical-bond level, revealing the impact of chemical-bonding configurations and atomic mass on local phonon modes in graphene with a new level of sensitivity.
A hydrogel-based modular lymphoma organoid identifies how lymphoid microenvironment cues dampen the effect of MALT1 inhibitors and informs effective combination therapies to rescue the treatment response
We report the observation of narrowband terahertz emission from a quasi-one-dimensional charge-density-wave insulator, (TaSe4)2I. The origin of the emitted radiation is interpreted as a phason that obtains mass due to the long-range Coulomb interaction.
Large-size single-crystal van der Waals layered Bi2SeO5 has been synthesized with a high dielectric constant and high breakdown field strength for two-dimensional electronics applications.
The authors report on the emergence of intercell moiré exciton complexes where, in H-stacked WS2/WSe2 heterobilayers, the exciton’s hole from the WSe2 layer is surrounded by its bound electron’s wavefunction distributed among three adjacent moiré traps in the WS2 layer exhibiting an out-of-plane dipole and in-plane quadrupole.
The authors demonstrate optically induced ultrafast magnetization reversal taking place within less than a picosecond in rare-earth-free spin valves of [Pt/Co]/Cu/[Co/Pt].
The authors present scanning tunnelling spectroscopy data that show that the mechanism of superconductivity in overdoped cuprate superconductors is qualitatively different from conventional mean-field theory.
Time-dependent pump–probe studies of polaritonic transport — for polaritons formed by strong coupling between organic molecules and Bloch surface waves at the interface of a distributed Bragg reflector — reveal a transition between diffusive and ballistic behaviour.
A large-scale screening identifies an inhalable polymer nanoparticle formulation that safely and effectively delivers therapeutic mRNA molecules to the lungs of several animal species.
Targeting P-selectin enables safer and more effective nanomedicine delivery through caveolin-1-mediated endothelial transcytosis in preclinical medulloblastoma tumour models.
A measure of the impact of scientific papers indicates that they are on average becoming less disruptive — this could reflect changes in the scientific community.
