Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 9 Issue 4, April 2003

Neurogenesis in the adult brain has been an active topic of recent research. On page 439, Nunes et al. show that the subcortical white matter of the adult human brain harbors multipotential neural progenitor cells. These cells, selected with the A2B5 marker, are known to give rise to oligodendrocytes, but the new work suggests that multiple fates can be elicited under defined culture conditions. The cover depicts a white-matter progenitor-derived neurosphere giving rise in culture to multiple cell types, including ßIII-tubulin+ neurons (red), GFAP+ astrocytes (blue) and O4+ oligodendrocytes (green). Original magnification, x200.

Editorial

Top of page ⤴

Letters to the Editor

Top of page ⤴

News

Top of page ⤴

Commentary

Top of page ⤴

Book Review

Top of page ⤴

News & Views

  • The first examination of a brain from a patient enrolled in a halted clinical trial for an Alzheimer disease (AD) vaccine reveals striking—and potentially dangerous—effects.

    • S. M. Greenberg
    • B. J. Bacskai
    • B. T. Hyman
    News & Views
  • A new model addresses the evolutionary mechanisms for antibiotic resistance and comes up with some grim forecasts. In the United States, resistance of Streptococcus pneumoniae to two commonly prescribed antibiotics is predicted to reach 41% by 2004 (pages 424–430).

    • Allison McGeer
    • Donald E. Low
    News & Views
  • HIV-1 readily mutates to escape the immune response, evolving in ways that allow it to persist in the host. New findings reveal that HIV-1 protects itself from antibodies by putting up a shield of constantly shifting sugar moieties. This shield may be contributing to the poor performance of candidate HIV-1 vaccines.

    • John R. Mascola
    • David C. Montefiori
    News & Views
Top of page ⤴

Article

Top of page ⤴

On the Market

Top of page ⤴

Erratum

Top of page ⤴

Corrigendum

Top of page ⤴

Search

Quick links