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Volume 28 Issue 3, March 2022

Health in the Amazon

Local communities protect the Amazon rainforest from illegal logging and mining, but this is threatened by a lack of local healthcare. Journalist Sofia Moutinho traveled with a medical team who delivered vaccines for COVID-19 and other supplies during a monthlong boat trip along the Amazon River.

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Image credit: Sofia Moutinho Cover design: Marina Spence

Volume 28 Issue 3

Editorial

  • The use of transgenic pigs as a source of organs and tissues for patients in need could revolutionize medicine — but to achieve that goal, data from clinical trials and forthright assessment of the ethics of animal-to-human transplants will be critical.

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News & Views

  • New data confirm that the COVID-19 vaccine booster dose is crucial for the generation of neutralizing antibody responses against Omicron, while better therapeutic antibodies are needed for this and future variants.

    • Xiaoying Shen
    News & Views
  • New technologies are expanding the reach and accessibility of preimplantation genetic testing of human embryos. But what these advances can deliver is still unclear, and a frank assessment of their profound ethical implications is urgently needed.

    • Josephine Johnston
    • Lucas J. Matthews
    News & Views
  • A first-in-class therapeutic that targets neuroactive microbial metabolites in the gut shows promising target engagement, safety and behavioral improvements in adolescents with autism spectrum disorder.

    • Rochellys Diaz Heijtz
    • Pierre Gressens
    • Jonathan R. Swann
    News & Views
  • A prospective meta-analysis supports the cardiovascular safety of the dual incretin receptor agonist tirzepatide, after promising clinical outcomes in the SURPASS-4 study.

    • Filipe A. Moura
    • Benjamin M. Scirica
    • Christian T. Ruff
    News & Views
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Research Briefings

  • Bone marrow transplantation causes peripheral cells to engraft the brain by an unclear mechanism. Microglia, the brain’s immune cells, lose their regenerative capacity when the bone marrow transplantation chemotherapy agent busulfan arrests their cell cycle. This causes a gradual decrease in microglial density, creating a niche for peripheral donor cells to engraft the brain and become resident macrophages.

    Research Briefing
  • Analyses of primary myelodysplastic syndrome (MDS) samples from the largest cohort ever evaluated demonstrate that the hematopoietic stem cell populations that originate MDS have distinct differentiation phenotypes and associated signaling pathways. These differences can be targeted with selective therapies that could benefit patients with progressed disease.

    Research Briefing
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Amendments & Corrections

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