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Volume 27 Issue 3, March 2021

Volume 27 Issue 3

Focus on outbreaks

The cover image was painted by Ali Al-Nasser, a medical laboratory technologist from Zahra (Kuwait), and portrays him working at the bench while preparing SARS-CoV-2 nasopharyngeal swabs for DNA extraction. The COVID-19 pandemic disrupted the course of normal life; like Ali Al-Nasser, many scientists turned to art to provide them with an escape from the stress of everyday life in lockdown.

See Focus

Image credit: Ali Al-Nasser. Cover design: Marina Spence.


News Feature

  • News Feature |

    Although many health experts around the world must stay focused on the ongoing viral pandemic caused by SARS-CoV-2, similar viruses and microbial organisms such as bacteria could create the next global killer. Experts discuss the most likely culprits.

    • Mike May


World View


News & Views

  • News & Views |

    A large genomic surveillance effort in South Africa produced 1,365 high-quality whole genomes of SARS-CoV-2; this has identified 16 new lineages of the virus that had not been identified in other countries.

    • Anise N. Happi
    • Chinedu A. Ugwu
    • Christian T. Happi
  • News & Views |

    An analysis of life expectancy and cause of death in 363 Latin American cities unveils wide differences between cities in the same country, and sheds light on the socioeconomic factors that determine how long people live and how they die.

    • Fernando Lanas
    • Pamela Seron
  • News & Views |

    Antisense oligonucleotides that target lamin A/C pre-mRNA decrease both progerin transcript levels and progerin protein levels and extend lifespan in an animal model of Hutchinson–Gilford progeria syndrome.

    • Gwladys Revêchon
    • Daniel Whisenant
    • Maria Eriksson


Review Articles


  • Letter | | Open Access

    Single-cell transcriptomic analysis of metastatic castration-resistant prostate cancer uncovers pervasive coexpression of androgen receptor isoforms and cancer cell–intrinsic and microenvironmental programs of treatment resistance

    • Meng Xiao He
    • Michael S. Cuoco
    • Eliezer M. Van Allen
  • Letter |

    Interrogation of 1,365 near whole-genome sequences of SARS-CoV-2 variants isolated in South Africa during the first 6 months of the global pandemic reveals three major monophyletic lineages responsible for more than half of the infections in the country and underscores the value of integrating genomic surveillance methods to inform the national pandemic response.

    • Houriiyah Tegally
    • Eduan Wilkinson
    • Tulio de Oliveira
  • Letter |

    New analysis tracking the course of the COVID-19 epidemic in sub-Saharan Africa shows high country-to-country variation in disease and mortality burdens, as well as demonstrating a minimal role for climate in the spread of SARS-CoV-2 when compared with other factors, such as human mobility.

    • Benjamin L. Rice
    • Akshaya Annapragada
    • C. Jessica E. Metcalf



  • Analysis |

    An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

    • Christoph Muus
    • Malte D. Luecken
    • Xiaohui Zhang

Amendments & Corrections


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