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Volume 27 Issue 2, February 2021

Volume 27 Issue 2

Neuromodulation for compulsive behavior

Grover and colleagues report that non-invasive modulation of high-frequency brain rhythms improves obsessive–compulsive behaviors. Using personalized high-definition transcranial alternating-current stimulation (HD-tACS), the team modulated brain rhythms in the reward-processing circuitry to reduce obsessive–compulsive symptoms. The cover depicts the neuromodulation electrodes placed on the scalp of the study participants, and represents the consequent improvements in mental health. The cover exemplifies the dawn of non-invasive neuromodulation in experimental psychiatric medicine.

See Grover and colleagues

Image credit: John Anh Nguyen. Cover design: Marina Spence.


  • Editorial |

    Diverging from tested vaccination regimens without scientific evidence could undermine public confidence in vaccines against COVID-19 and the success of a global vaccination strategy to curtail the pandemic.


  • News |

    In the past year, there has been more CRISPR news than the awarding of the Nobel Prize in Chemistry to Jennifer Doudna and Emmanuelle Charpentier. Gene editing has continued its forward momentum in major ways, and scientists are beginning to see results.

    • Carrie Arnold



  • Comment |

    Unexpected direct and indirect risks of participating in clinical trials have emerged during COVID-19 that investigators and institutional review boards may not be sure how to investigate. How should existing guidance and ethical frameworks for clinical trials be applied in a pandemic setting?

    • Nina S. Hsu
    • Saskia Hendriks
    • Christine Grady
  • Comment |

    An increasing amount of publications are recognizing that a person’s risk of diabetes and diabetes outcomes are influenced largely by social determinants of health. This renewed understanding of disease should influence health provision and diabetes research, but will it?

    • Jacqueline A. Seiglie
    • Devaki Nambiar
    • J. Jaime Miranda

News & Views


  • Perspective |

    A comprehensive strategy for the next steps to ensure vaccination of the global population against SARS-CoV-2 is now required, and key steps and challenges are detailed in this Perspective.

    • Jerome H. Kim
    • Florian Marks
    • John D. Clemens

Review Articles

Brief Communications



Amendments & Corrections


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