Volume 26 Issue 9, September 2020

Volume 26 Issue 9

Guidelines for AI in clinical trials

The image on the cover illustrates the potential of artificial intelligence (AI) to enhance healthcare delivery. In this issue, new extensions of SPIRIT and CONSORT guidelines dedicated to randomized clinical trials involving AI delineate the reporting standards for these interventions, and Nimri and colleagues report the results of a randomized clinical trial evaluating the performance of an AI for optimizing insulin dosing in patients with type 1 diabetes.

See Revital Nimri et al.

Image credit: Zohar Nave. Cover design: Erin Dewalt.

Editorial

  • Editorial |

    Delivering the potential of artificial intelligence in clinical decision-making will require testing interventions in well-designed randomized clinical trials and reporting these results in a standardized and transparent fashion.

News Feature

Correspondence

World View

  • World View |

    Being a parent scientist can feel like a catch-22, feeling guilty for both the time spent away from the children and the time spent away from the bench. Embracing healthy boundaries can be liberating but will only go so far if childcare remains unaffordable.

    • Miriam Merad

Comment

  • Comment |

    With only a limited number of clinical trials of artificial intelligence in medicine thus far, the first guidelines for protocols and reporting arrive at an opportune time. Better protocol design, along with consistent and complete data presentation, will greatly facilitate interpretation and validation of these trials, and will help the field to move forward.

    • Eric J. Topol
  • Comment |

    Many widely used health algorithms have been shown to encode and reinforce racial health inequities, prioritizing the needs of white patients over those of patients of color. Because automated systems are becoming so crucial to access to health, researchers in the field of artificial intelligence must become actively anti-racist. Here we list some concrete steps to enable anti-racist practices in medical research and practice.

    • Kellie Owens
    •  & Alexis Walker
  • Comment |

    In the current COVID-19 pandemic, many researchers are applying to research ethics committees for deferred-consent procedures for protocols that aim either to test treatments or to obtain tissue or samples from research participants. However, the deferred-consent procedure has not been developed for pandemics. In this Comment, we interpret existing guidance documents and argue when and under which conditions deferred consent can be considered ethically acceptable in a pandemic.

    • Rieke van der Graaf
    • , Marie-Astrid Hoogerwerf
    •  & Martine C. de Vries

Research Highlights

News & Views

  • News & Views |

    In a study of 96,476 participants from the UK Biobank cohort who had their physical activity objectively measured by accelerometer, both the volume of physical activity and its intensity were associated with risk of mortality.

    • Jason M. R. Gill
  • News & Views |

    Modeling the impact of COVID-19-mitigation strategies on malarial case management and prevention by health services in sub-Saharan Africa predicts 81,000 additional deaths in Nigeria and 769,000 in sub-Saharan Africa in 2020.

    • Rashid Ansumana
    • , Osman Sankoh
    •  & Alimuddin Zumla
  • News & Views |

    Vaccines directed against SARS-CoV-2 have been administered to healthy volunteers and have been shown to stimulate a brisk humoral and cellular immune response. All vaccines were generally well tolerated with mostly mild to moderate local and systemic reactions.

    • Kathryn M. Edwards

Perspectives

  • Perspective |

    A strategy for assessing the effectiveness of different strategies for HIV cure is presented.

    • Mohamed Abdel-Mohsen
    • , Douglas Richman
    • , Robert F. Siliciano
    • , Michel C. Nussenzweig
    • , Bonnie J. Howell
    • , Javier Martinez-Picado
    • , Nicolas Chomont
    • , Katharine J. Bar
    • , Xu G. Yu
    • , Mathias Lichterfeld
    • , Jose Alcami
    • , Daria Hazuda
    • , Frederic Bushman
    • , Janet D. Siliciano
    • , Michael R. Betts
    • , Adam M. Spivak
    • , Vicente Planelles
    • , Beatrice H. Hahn
    • , Davey M. Smith
    • , Ya-Chi Ho
    • , Maria J. Buzon
    • , Christian Gaebler
    • , Mirko Paiardini
    • , Qingsheng Li
    • , Jacob D. Estes
    • , Thomas J. Hope
    • , Jay Kostman
    • , Karam Mounzer
    • , Marina Caskey
    • , Lawrence Fox
    • , Ian Frank
    • , James L. Riley
    • , Pablo Tebas
    • , Luis J. Montaner
    • , Mohamed Abdel-Mohsen
    • , Douglas Richman
    • , Robert F. Siliciano
    • , Michel C. Nussenzweig
    • , Bonnie J. Howell
    • , Javier Martinez-Picado
    • , Nicolas Chomont
    • , Katharine J. Bar
    • , Xu G. Yu
    • , Mathias Lichterfeld
    • , Jose Alcami
    • , Daria Hazuda
    • , Frederic Bushman
    • , Janet D. Siliciano
    • , Michael R. Betts
    • , Adam M. Spivak
    • , Vicente Planelles
    • , Beatrice H. Hahn
    • , Davey M. Smith
    • , Ya-Chi Ho
    • , Maria J. Buzon
    • , Christian Gaebler
    • , Mirko Paiardini
    • , Qingsheng Li
    • , Jacob D. Estes
    • , Thomas J. Hope
    • , Jay Kostman
    • , Karam Mounzer
    • , Marina Caskey
    • , Lawrence Fox
    • , Ian Frank
    • , James L. Riley
    • , Pablo Tebas
    •  & Luis J. Montaner

Consensus Statements

  • Consensus Statement | | Open Access

    The CONSORT-AI and SPIRIT-AI extensions improve the transparency of clinical trial design and trial protocol reporting for artificial intelligence interventions.

    • Samantha Cruz Rivera
    • , Xiaoxuan Liu
    • , An-Wen Chan
    • , Alastair K. Denniston
    • , Melanie J. Calvert
    • , Ara Darzi
    • , Christopher Holmes
    • , Christopher Yau
    • , David Moher
    • , Hutan Ashrafian
    • , Jonathan J. Deeks
    • , Lavinia Ferrante di Ruffano
    • , Livia Faes
    • , Pearse A. Keane
    • , Sebastian J. Vollmer
    • , Aaron Y. Lee
    • , Adrian Jonas
    • , Andre Esteva
    • , Andrew L. Beam
    • , Maria Beatrice Panico
    • , Cecilia S. Lee
    • , Charlotte Haug
    • , Christophe J. Kelly
    • , Christopher Yau
    • , Cynthia Mulrow
    • , Cyrus Espinoza
    • , John Fletcher
    • , David Moher
    • , Dina Paltoo
    • , Elaine Manna
    • , Gary Price
    • , Gary S. Collins
    • , Hugh Harvey
    • , James Matcham
    • , Joao Monteiro
    • , M. Khair ElZarrad
    • , Lavinia Ferrante di Ruffano
    • , Luke Oakden-Rayner
    • , Melissa McCradden
    • , Pearse A. Keane
    • , Richard Savage
    • , Robert Golub
    • , Rupa Sarkar
    •  & Samuel Rowley
  • Consensus Statement | | Open Access

    The CONSORT-AI and SPIRIT-AI extensions improve the transparency of clinical trial design and trial protocol reporting for artificial intelligence interventions.

    • Xiaoxuan Liu
    • , Samantha Cruz Rivera
    • , David Moher
    • , Melanie J. Calvert
    • , Alastair K. Denniston
    • , An-Wen Chan
    • , Ara Darzi
    • , Christopher Holmes
    • , Christopher Yau
    • , Hutan Ashrafian
    • , Jonathan J. Deeks
    • , Lavinia Ferrante di Ruffano
    • , Livia Faes
    • , Pearse A. Keane
    • , Sebastian J. Vollmer
    • , Aaron Y. Lee
    • , Adrian Jonas
    • , Andre Esteva
    • , Andrew L. Beam
    • , An-Wen Chan
    • , Maria Beatrice Panico
    • , Cecilia S. Lee
    • , Charlotte Haug
    • , Christopher J. Kelly
    • , Christopher Yau
    • , Cynthia Mulrow
    • , Cyrus Espinoza
    • , John Fletcher
    • , Dina Paltoo
    • , Elaine Manna
    • , Gary Price
    • , Gary S. Collins
    • , Hugh Harvey
    • , James Matcham
    • , Joao Monteiro
    • , M. Khair ElZarrad
    • , Lavinia Ferrante di Ruffano
    • , Luke Oakden-Rayner
    • , Melissa McCradden
    • , Pearse A. Keane
    • , Richard Savage
    • , Robert Golub
    • , Rupa Sarkar
    •  & Samuel Rowley

Brief Communications

Letters

  • Letter |

    The randomized-controlled trial ADVICE4U demonstrates non-inferiority of an automated AI-based decision support system compared with advice from expert physicians for optimal insulin dosing in youths with type 1 diabetes.

    • Revital Nimri
    • , Tadej Battelino
    • , Lori M. Laffel
    • , Robert H. Slover
    • , Desmond Schatz
    • , Stuart A. Weinzimer
    • , Klemen Dovc
    • , Thomas Danne
    • , Moshe Phillip
    • , Moshe Phillip
    • , Revital Nimri
    • , Shlomit Shalitin
    • , Rachel Bello
    • , Michal Nevo-Shenker
    • , Naama Fisch-Shvalb
    • , Galit Shiovitch-Mantzuri
    • , Orit Choresh
    • , Irit Drutz
    • , Yehiel Nava
    • , Alona Hemo
    • , Orna Hermon
    • , Rachel Nave
    • , Tadej Battelino
    • , Klemen Dovc
    • , Natasa Bratina
    • , Darja Smigoe-Schweiger
    • , Brigita Mali
    • , Ana Gianini
    • , Urska Sever
    • , Barbara Murn Berkopec
    • , Lori M. Laffel
    • , Michelle Katz
    • , Elvira Isganaitis
    • , Sanjeev Mehta
    • , Heidi Quinn
    • , Nisha Naik
    • , Zijing Guo
    • , Lisa Volkening
    • , Robert H. Slover
    • , Gregory Forlenza
    • , R. Paul Wadwa
    • , G. Todd Alonso
    • , Laurel Messer
    • , Lindsey Towers
    • , Katie Thivener
    • , Cari Berget
    • , Samantha Lange
    • , Emily Jost
    • , Maria Rossick-Solis
    • , Desmond Schatz
    • , Michael Haller
    • , Paul Hiers
    • , Laura Jacobsen
    • , Madison Smith
    • , Anastasia O’Neill
    • , Jennifer Hosford
    • , Alexis Perry
    • , Stuart A. Weinzimer
    • , Eda Cengiz
    • , Jennifer Sherr
    • , Kathryn Gibbons
    • , Lori Carria
    • , Melinda Zgorski
    • , Thomas Danne
    • , Torben Biester
    • , Olga Kordonouri
    • , Thekla von dem Berge
    • , Sarah Biester
    •  & Kerstin Remus
  • Letter |

    Analysis of UK Biobank participants with wearable physical activity monitors demonstrates that high-volume physical activity and high-intensity activity are associated with reduced mortality.

    • Tessa Strain
    • , Katrien Wijndaele
    • , Paddy C. Dempsey
    • , Stephen J. Sharp
    • , Matthew Pearce
    • , Justin Jeon
    • , Tim Lindsay
    • , Nick Wareham
    •  & Søren Brage
  • Letter |

    Whole-exome sequencing is not sensitive or specific enough to replace the gold standard of tandem mass spectrometry screening of rare inborn errors of metabolism, but can help to reduce false positives and facilitate the timely resolution of ambiguous cases.

    • Aashish N. Adhikari
    • , Renata C. Gallagher
    • , Yaqiong Wang
    • , Robert J. Currier
    • , George Amatuni
    • , Laia Bassaganyas
    • , Flavia Chen
    • , Kunal Kundu
    • , Mark Kvale
    • , Sean D. Mooney
    • , Robert L. Nussbaum
    • , Savanna S. Randi
    • , Jeremy Sanford
    • , Joseph T. Shieh
    • , Rajgopal Srinivasan
    • , Uma Sunderam
    • , Hao Tang
    • , Dedeepya Vaka
    • , Yangyun Zou
    • , Barbara A. Koenig
    • , Pui-Yan Kwok
    • , Neil Risch
    • , Jennifer M. Puck
    •  & Steven E. Brenner
  • Letter |

    The combination of nearly real-time genome sequencing of SARS-CoV-2 in infected patients during the first 10 weeks of COVID-19 containment in Australia and epidemiological modeling is helping in understanding the dynamics of the COVID-19 pandemic and potentially guiding public health decisions.

    • Rebecca J. Rockett
    • , Alicia Arnott
    • , Connie Lam
    • , Rosemarie Sadsad
    • , Verlaine Timms
    • , Karen-Ann Gray
    • , John-Sebastian Eden
    • , Sheryl Chang
    • , Mailie Gall
    • , Jenny Draper
    • , Eby M. Sim
    • , Nathan L. Bachmann
    • , Ian Carter
    • , Kerri Basile
    • , Roy Byun
    • , Matthew V. O’Sullivan
    • , Sharon C-A Chen
    • , Susan Maddocks
    • , Tania C. Sorrell
    • , Dominic E. Dwyer
    • , Edward C. Holmes
    • , Jen Kok
    • , Mikhail Prokopenko
    •  & Vitali Sintchenko
  • Letter |

    The combination of near to real-time whole-genome sequence analysis and epidemiology resulted in reliable assessments of the extent of SARS-CoV-2 transmission in the community, facilitating early decision-making to control local transmission of SARS-CoV-2 in the Netherlands.

    • Bas B. Oude Munnink
    • , David F. Nieuwenhuijse
    • , Mart Stein
    • , Áine O’Toole
    • , Manon Haverkate
    • , Madelief Mollers
    • , Sandra K. Kamga
    • , Claudia Schapendonk
    • , Mark Pronk
    • , Pascal Lexmond
    • , Anne van der Linden
    • , Theo Bestebroer
    • , Irina Chestakova
    • , Ronald J. Overmars
    • , Stefan van Nieuwkoop
    • , Richard Molenkamp
    • , Annemiek A. van der Eijk
    • , Corine GeurtsvanKessel
    • , Harry Vennema
    • , Adam Meijer
    • , Andrew Rambaut
    • , Jaap van Dissel
    • , Reina S. Sikkema
    • , Aura Timen
    • , Marion Koopmans
    • , G. J. A. P. M. Oudehuis
    • , Janke Schinkel
    • , Jan Kluytmans
    • , Marjolein Kluytmans-van den Bergh
    • , Wouter van den Bijllaardt
    • , Robbert G. Berntvelsen
    • , Miranda M. L. van Rijen
    • , Peter Schneeberger
    • , Suzan Pas
    • , Bram M. Diederen
    • , Anneke M. C. Bergmans
    • , P. A. Verspui van der Eijk
    • , Jaco J. Verweij
    • , Anton G. N. Buiting
    • , Roel Streefkerk
    • , A. P. Aldenkamp
    • , P. de Man
    • , J. G. M. Koelemal
    • , D. Ong
    • , S. Paltansing
    • , N. Veassen
    • , Jacqueline Sleven
    • , Leendert Bakker
    • , Heinrich Brockhoff
    • , Ariene Rietveld
    • , Fred Slijkerman Megelink
    • , James Cohen Stuart
    • , Anne de Vries
    • , Wil van der Reijden
    • , A. Ros
    • , Esther Lodder
    • , Ellen Verspui-van der Eijk
    • , Inge Huijskens
    • , E. M. Kraan
    • , M. P. M. van der Linden
    • , S. B. Debast
    • , N. Al Naiemi
    • , A. C. M. Kroes
    • , Marjolein Damen
    • , Sander Dinant
    • , Sybren Lekkerkerk
    • , Oscar Pontesilli
    • , Pieter Smit
    • , Carla van Tienen
    • , P. C. R. Godschalk
    • , Jorien van Pelt
    • , Alewijn Ott
    • , Charlie van der Weijden
    • , Heiman Wertheim
    • , Janette Rahamat-Langendoen
    • , Johan Reimerink
    • , Rogier Bodewes
    • , Erwin Duizer
    • , Bas van der Veer
    • , Chantal Reusken
    • , Suzanne Lutgens
    • , Peter Schneeberger
    • , Mirjam Hermans
    • , P. Wever
    • , A. Leenders
    • , Henriette ter Waarbeek
    •  & Christian Hoebe
  • Letter |

    Transmission dynamics models of COVID-19 and malaria reveal how different scenarios of COVID-19 spread and varying levels of interruption to antimalarial programs could result in increased deaths in sub-Saharan Africa.

    • Ellie Sherrard-Smith
    • , Alexandra B. Hogan
    • , Arran Hamlet
    • , Oliver J. Watson
    • , Charlie Whittaker
    • , Peter Winskill
    • , Fatima Ali
    • , Audu B. Mohammad
    • , Perpetua Uhomoibhi
    • , Ibrahim Maikore
    • , Nnenna Ogbulafor
    • , Jamilu Nikau
    • , Mara D. Kont
    • , Joseph D. Challenger
    • , Robert Verity
    • , Ben Lambert
    • , Matthew Cairns
    • , Bhargavi Rao
    • , Marc Baguelin
    • , Lilith K. Whittles
    • , John A. Lees
    • , Sangeeta Bhatia
    • , Edward S. Knock
    • , Lucy Okell
    • , Hannah C. Slater
    • , Azra C. Ghani
    • , Patrick G. T. Walker
    • , Okefu Oyale Okoko
    •  & Thomas S. Churcher
  • Letter |

    A new study that models the COVID-19 epidemic in France suggests that although a second peak is likely unavoidable, maintaining social distancing and wearing masks when lockdown restrictions are lifted, as well as continuing to shelter vulnerable individuals, will reduce mortality and avoid overwhelming ICU facilities.

    • Nicolas Hoertel
    • , Martin Blachier
    • , Carlos Blanco
    • , Mark Olfson
    • , Marc Massetti
    • , Marina Sánchez Rico
    • , Frédéric Limosin
    •  & Henri Leleu
  • Letter |

    A platform for rapid antibody discovery enabled the isolation of hundreds of human monoclonal antibodies against SARS-CoV-2 and the prioritization of potent antibody candidates for clinical trials in patients with COVID-19.

    • Seth J. Zost
    • , Pavlo Gilchuk
    • , Rita E. Chen
    • , James Brett Case
    • , Joseph X. Reidy
    • , Andrew Trivette
    • , Rachel S. Nargi
    • , Rachel E. Sutton
    • , Naveenchandra Suryadevara
    • , Elaine C. Chen
    • , Elad Binshtein
    • , Swathi Shrihari
    • , Mario Ostrowski
    • , Helen Y. Chu
    • , Jonathan E. Didier
    • , Keith W. MacRenaris
    • , Taylor Jones
    • , Samuel Day
    • , Luke Myers
    • , F. Eun-Hyung Lee
    • , Doan C. Nguyen
    • , Ignacio Sanz
    • , David R. Martinez
    • , Paul W. Rothlauf
    • , Louis-Marie Bloyet
    • , Sean P. J. Whelan
    • , Ralph S. Baric
    • , Larissa B. Thackray
    • , Michael S. Diamond
    • , Robert H. Carnahan
    •  & James E. Crowe Jr.
  • Letter |

    In a cohort of recovered patients with COVID-19, virus spike-specific antibodies were consistently elicited, but neutralizing activity was highly variable and inversely correlated with the proportion of CCR6+CXCR3 spike-specific circulating follicular helper T cells.

    • Jennifer A. Juno
    • , Hyon-Xhi Tan
    • , Wen Shi Lee
    • , Arnold Reynaldi
    • , Hannah G. Kelly
    • , Kathleen Wragg
    • , Robyn Esterbauer
    • , Helen E. Kent
    • , C. Jane Batten
    • , Francesca L. Mordant
    • , Nicholas A. Gherardin
    • , Phillip Pymm
    • , Melanie H. Dietrich
    • , Nichollas E. Scott
    • , Wai-Hong Tham
    • , Dale I. Godfrey
    • , Kanta Subbarao
    • , Miles P. Davenport
    • , Stephen J. Kent
    •  & Adam K. Wheatley
  • Letter |

    Culturable Mycobacterium tuberculosis can be detected in cough aerosol from a high proportion of individuals infected with drug-resistant M. tuberculosis and correlate with a strong cough and low symptom score, indicating the need to focus on targeted interventions.

    • Grant Theron
    • , Jason Limberis
    • , Rouxjeane Venter
    • , Liezel Smith
    • , Elize Pietersen
    • , Aliasgar Esmail
    • , Greg Calligaro
    • , Julian te Riele
    • , Marianna de Kock
    • , Paul van Helden
    • , Tawanda Gumbo
    • , Taane G. Clark
    • , Kevin Fennelly
    • , Robin Warren
    •  & Keertan Dheda
  • Letter |

    An antisense oligonucleotide induces exon skipping in cell lines derived from patients with CLN3 Batten disease, and reduces lysosomal impairment and ameliorates neurological phenotypes in a mouse model of the disease.

    • Jessica L. Centa
    • , Francine M. Jodelka
    • , Anthony J. Hinrich
    • , Tyler B. Johnson
    • , Joseph Ochaba
    • , Michaela Jackson
    • , Dominik M. Duelli
    • , Jill M. Weimer
    • , Frank Rigo
    •  & Michelle L. Hastings
  • Letter |

    By reprogramming innate immune cells to an immunosuppressive phenotype, myocardial infarction accelerates breast cancer progression in mice, and the clinical relevance of these findings was demonstrated in individuals with early-stage breast cancer who experienced cardiovascular events after cancer diagnosis.

    • Graeme J. Koelwyn
    • , Alexandra A. C. Newman
    • , Milessa S. Afonso
    • , Coen van Solingen
    • , Emma M. Corr
    • , Emily J. Brown
    • , Kathleen B. Albers
    • , Naoko Yamaguchi
    • , Deven Narke
    • , Martin Schlegel
    • , Monika Sharma
    • , Lianne C. Shanley
    • , Tessa J. Barrett
    • , Karishma Rahman
    • , Valeria Mezzano
    • , Edward A. Fisher
    • , David S. Park
    • , Jonathan D. Newman
    • , Daniela F. Quail
    • , Erik R. Nelson
    • , Bette J. Caan
    • , Lee W. Jones
    •  & Kathryn J. Moore
  • Letter |

    A phase 1 dose-escalating trial evaluating CD70 inhibition in combination with hypomethylating therapy results in the elimination of leukemia stem cells and achieves clinical activity in untreated patients with acute myeloid leukemia.

    • Carsten Riether
    • , Thomas Pabst
    • , Sabine Höpner
    • , Ulrike Bacher
    • , Magdalena Hinterbrandner
    • , Yara Banz
    • , Rouven Müller
    • , Markus G. Manz
    • , Walid H. Gharib
    • , David Francisco
    • , Remy Bruggmann
    • , Luc van Rompaey
    • , Mahan Moshir
    • , Tim Delahaye
    • , Domenica Gandini
    • , Ellen Erzeel
    • , Anna Hultberg
    • , Samson Fung
    • , Hans de Haard
    • , Nicolas Leupin
    •  & Adrian F. Ochsenbein

Articles

  • Article |

    In a phase II clinical trial of patients with classical Hodgkin lymphoma, peripheral CD4+ T cell receptor diversity and the abundance of mature natural killer cells and CD3CD68+CD4+GrB+ innate cells were associated with favorable responses to anti-PD-1 monotherapy.

    • Fathima Zumla Cader
    • , Xihao Hu
    • , Walter L. Goh
    • , Kirsty Wienand
    • , Jing Ouyang
    • , Elisa Mandato
    • , Robert Redd
    • , Lee N. Lawton
    • , Pei-Hsuan Chen
    • , Jason L. Weirather
    • , Ron C. J. Schackmann
    • , Bo Li
    • , Wenjiang Ma
    • , Philippe Armand
    • , Scott J. Rodig
    • , Donna Neuberg
    • , X. Shirley Liu
    •  & Margaret A. Shipp
  • Article |

    Multimodal single-cell profiling reveals heterogeneity of colonic CD8+ T cells in patients with ulcerative colitis, including expansion of a chronically activated IL-26-expressing subpopulation with innate-like features.

    • Daniele Corridoni
    • , Agne Antanaviciute
    • , Tarun Gupta
    • , David Fawkner-Corbett
    • , Anna Aulicino
    • , Marta Jagielowicz
    • , Kaushal Parikh
    • , Emmanouela Repapi
    • , Steve Taylor
    • , Dai Ishikawa
    • , Ryo Hatano
    • , Taketo Yamada
    • , Wei Xin
    • , Hubert Slawinski
    • , Rory Bowden
    • , Giorgio Napolitani
    • , Oliver Brain
    • , Chikao Morimoto
    • , Hashem Koohy
    •  & Alison Simmons

Amendments & Corrections

  • Author Correction |

    • Alexander W. Charney
    • , Nicole W. Simons
    • , Konstantinos Mouskas
    • , Lauren Lepow
    • , Esther Cheng
    • , Jessica Le Berichel
    • , Christie Chang
    • , Robert Marvin
    • , Diane Marie Del Valle
    • , Sharlene Calorossi
    • , Alona Lansky
    • , Laura Walker
    • , Manishkumar Patel
    • , Hui Xie
    • , Nancy Yi
    • , Alex Yu
    • , Gurpawan Kang
    • , Lora E. Liharska
    • , Emily Moya
    • , Matthew Hartnett
    • , Sandra Hatem
    • , Lillian Wilkins
    • , Melody Eaton
    • , Hajra Jamal
    • , Kevin Tuballes
    • , Steven T. Chen
    • , Jonathan Chung
    • , Jocelyn Harris
    • , Craig Batchelor
    • , Jose Lacunza
    • , Mahlet Yishak
    • , Kimberly Argueta
    • , Neha Karekar
    • , Brian Lee
    • , Geoffrey Kelly
    • , Daniel Geanon
    • , Diana Handler
    • , John Leech
    • , Hiyab Stefanos
    • , Travis Dawson
    • , Ieisha Scott
    • , Nancy Francoeur
    • , Jessica S. Johnson
    • , Akhil Vaid
    • , Benjamin S. Glicksberg
    • , Girish N. Nadkarni
    • , Eric E. Schadt
    • , Bruce D. Gelb
    • , Adeeb Rahman
    • , Robert Sebra
    • , Glenn Martin
    • , Charuta Agashe
    • , Priyal Agrawal
    • , Kasey Alesso-Carra
    • , Eziwoma Alibo
    • , Kelvin Alvarez
    • , Angelo Amabile
    • , Steven Ascolillo
    • , Rasheed Bailey
    • , Priya Begani
    • , Paloma Bravo Correra
    • , Stacey-Ann Brown
    • , Mark Buckup
    • , Larissa Burka
    • , Lena Cambron
    • , Gina Carrara
    • , Serena Chang
    • , Jonathan Chien
    • , Mashkura Chowdhury
    • , Cansu Cimen Bozkus
    • , Phillip Comella
    • , Dana Cosgrove
    • , Francesca Cossarini
    • , Liam Cotter
    • , Arpit Dave
    • , Bheesham Dayal
    • , Maxime Dhainaut
    • , Rebecca Dornfeld
    • , Katie Dul
    • , Nissan Eber
    • , Cordelia Elaiho
    • , Frank Fabris
    • , Jeremiah Faith
    • , Dominique Falci
    • , Susie Feng
    • , Brian Fennessy
    • , Marie Fernandes
    • , Sandeep Gangadharan
    • , Joanna Grabowska
    • , Gavin Gyimesi
    • , Maha Hamdani
    • , Manon Herbinet
    • , Elva Herrera
    • , Arielle Hochman
    • , Gabriel E. Hoffman
    • , Jaime Hook
    • , Laila Horta
    • , Etienne Humblin
    • , Subha Karim
    • , Jessica Kim
    • , Dannielle Lebovitch
    • , Grace Lee
    • , Gyu Ho Lee
    • , Jacky Lee
    • , Mike Leventhal
    • , Katherine Lindblad
    • , Alexandra Livanos
    • , Rosalie Machado
    • , Zafar Mahmood
    • , Kelcey Mar
    • , Shrisha Maskey
    • , Paul Matthews
    • , Katherine Meckel
    • , Saurabh Mehandru
    • , Cynthia Mercedes
    • , Dara Meyer
    • , Gurkan Mollaoglu
    • , Sarah Morris
    • , Kai Nie
    • , Marjorie Nisenholtz
    • , George Ofori-Amanfo
    • , Kenan Onel
    • , Merouane Ounadjela
    • , Vishwendra Patel
    • , Cassandra Pruitt
    • , Shivani Rathi
    • , Jamie Redes
    • , Ivan Reyes-Torres
    • , Alcina Rodrigues
    • , Alfonso Rodriguez
    • , Vladimir Roudko
    • , Evelyn Ruiz
    • , Pearl Scalzo
    • , Pedro Silva
    • , Alessandra Soares Schanoski
    • , Meghan Straw
    • , Sasha Tabachnikova
    • , Collin Teague
    • , Bhaskar Upadhyaya
    • , Verena Van Der Heide
    • , Natalie Vaninov
    • , Daniel Wacker
    • , Hadley Walsh
    • , C. Matthias Wilk
    • , Jessica Wilson
    • , Karen M. Wilson
    • , Li Xue
    • , Naa-akomaah Yeboah
    • , Sabina Young
    • , Nina Zaks
    • , Renyuan Zha
    • , Thomas Marron
    • , Noam Beckmann
    • , Seunghee Kim-Schulze
    • , Sacha Gnjatic
    •  & Miriam Merad

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