Volume 26 Issue 6, June 2020

Volume 26 Issue 6

Diagnosis of skin diseases with AI

The cover illustration showcases the concept and functionality of the machine-learning model developed by Liu et al. to identify and assist in the diagnosis of skin conditions in routine clinical practice through everyday technology such as cellphones and laptops. By leveraging these devices, this research potentially expands universal access to high-quality information about skin conditions and may accelerate the deployment of digital solutions into clinical practice.

See Liu et al.

Image credit: Carson Young. Cover design: Erin Dewalt

Editorial

  • Editorial |

    Government officials who disseminate unsupported claims about the novel coronavirus undermine public trust in science and in the public-health efforts that are essential to bringing the COVID-19 pandemic under control.

Turning Points

Correspondence

World View

Comment

  • Comment |

    Necessity has been the mother of invention in the response to the COVID-19 pandemic, triggering many an innovation, often without the luxury of time to test these makeshift solutions to pressing problems. But there is much to be learned from times of crisis for times of plenty.

    • Matthew Harris
    • , Yasser Bhatti
    • , Jim Buckley
    •  & Dhananjaya Sharma
  • Comment |

    Researchers starting clinical trials of prevention measures for COVID-19 have a unique window of opportunity for collecting blood from the participants, at baseline and at the end of the trial, to be able to incorporate critical data into their analysis once serological tests for the causative coronavirus become available.

    • Marc Lipsitch
    • , Rebecca Kahn
    •  & Michael J. Mina
  • Comment |

    In the USA and around the world, the COVID-19 pandemic arrived as the population was fighting a devastating opioid overdose epidemic. Urgent and decisive action is needed to protect particularly vulnerable populations, such as those with opioid use disorder, to prevent a compounding effect on public health.

    • Sarah E. Wakeman
    • , Traci C. Green
    •  & Josiah Rich
  • Comment |

    Testing drug safety in people who are pregnant remains a wicked problem, but in the transition toward big data and machine learning, target trials could afford a viable alternative to randomized, controlled trials.

    • Anup P. Challa
    • , Robert R. Lavieri
    • , Ethan S. Lippmann
    • , Jeffery A. Goldstein
    • , Lisa Bastarache
    • , Jill M. Pulley
    •  & David M. Aronoff

Research Highlights

News & Views

Perspectives

Brief Communications

  • Brief Communication |

    Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8+ T cells in patients with moderate COVID-19.

    • Mingfeng Liao
    • , Yang Liu
    • , Jing Yuan
    • , Yanling Wen
    • , Gang Xu
    • , Juanjuan Zhao
    • , Lin Cheng
    • , Jinxiu Li
    • , Xin Wang
    • , Fuxiang Wang
    • , Lei Liu
    • , Ido Amit
    • , Shuye Zhang
    •  & Zheng Zhang
  • Brief Communication |

    A cross-sectional study of hospitalized patients with COVID-19 and a longitudinal follow-up study of patients with COVID-19 suggest that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset.

    • Quan-Xin Long
    • , Bai-Zhong Liu
    • , Hai-Jun Deng
    • , Gui-Cheng Wu
    • , Kun Deng
    • , Yao-Kai Chen
    • , Pu Liao
    • , Jing-Fu Qiu
    • , Yong Lin
    • , Xue-Fei Cai
    • , De-Qiang Wang
    • , Yuan Hu
    • , Ji-Hua Ren
    • , Ni Tang
    • , Yin-Yin Xu
    • , Li-Hua Yu
    • , Zhan Mo
    • , Fang Gong
    • , Xiao-Li Zhang
    • , Wen-Guang Tian
    • , Li Hu
    • , Xian-Xiang Zhang
    • , Jiang-Lin Xiang
    • , Hong-Xin Du
    • , Hua-Wen Liu
    • , Chun-Hui Lang
    • , Xiao-He Luo
    • , Shao-Bo Wu
    • , Xiao-Ping Cui
    • , Zheng Zhou
    • , Man-Man Zhu
    • , Jing Wang
    • , Cheng-Jun Xue
    • , Xiao-Feng Li
    • , Li Wang
    • , Zhi-Jie Li
    • , Kun Wang
    • , Chang-Chun Niu
    • , Qing-Jun Yang
    • , Xiao-Jun Tang
    • , Yong Zhang
    • , Xia-Mao Liu
    • , Jin-Jing Li
    • , De-Chun Zhang
    • , Fan Zhang
    • , Ping Liu
    • , Jun Yuan
    • , Qin Li
    • , Jie-Li Hu
    • , Juan Chen
    •  & Ai-Long Huang

Letters

  • Letter |

    A new study models the potential effects of preferentially deploying recovered individuals, who are seropositive for anti-SARS-CoV-2 antibodies, into the community to reduce the number of interactions between susceptible and infected people, thereby limiting transmission of the virus.

    • Joshua S. Weitz
    • , Stephen J. Beckett
    • , Ashley R. Coenen
    • , David Demory
    • , Marian Dominguez-Mirazo
    • , Jonathan Dushoff
    • , Chung-Yin Leung
    • , Guanlin Li
    • , Andreea Măgălie
    • , Sang Woo Park
    • , Rogelio Rodriguez-Gonzalez
    • , Shashwat Shivam
    •  & Conan Y. Zhao
  • Letter |

    A new epidemiological model, termed SIDARTHE, distinguishes between diagnosed and undiagnosed cases of SARS-CoV-2 infection, as well as modeling effects of social distancing and widespread testing, to predict possible outcomes of the COVID-19 epidemic in Italy.

    • Giulia Giordano
    • , Franco Blanchini
    • , Raffaele Bruno
    • , Patrizio Colaneri
    • , Alessandro Di Filippo
    • , Angela Di Matteo
    •  & Marta Colaneri
  • Letter |

    Detailed clinical and virologic characteristics of the first 12 individuals with COVID-19 in the United States from the US Centers for Disease Control and Prevention.

    • Stephanie A. Kujawski
    • , Karen K. Wong
    • , Jennifer P. Collins
    • , Lauren Epstein
    • , Marie E. Killerby
    • , Claire M. Midgley
    • , Glen R. Abedi
    • , N. Seema Ahmed
    • , Olivia Almendares
    • , Francisco N. Alvarez
    • , Kayla N. Anderson
    • , Sharon Balter
    • , Vaughn Barry
    • , Karri Bartlett
    • , Karlyn Beer
    • , Michael A. Ben-Aderet
    • , Isaac Benowitz
    • , Holly M. Biggs
    • , Alison M. Binder
    • , Stephanie R. Black
    • , Brandon Bonin
    • , Catherine H. Bozio
    • , Catherine M. Brown
    • , Hollianne Bruce
    • , Jonathan Bryant-Genevier
    • , Alicia Budd
    • , Diane Buell
    • , Rachel Bystritsky
    • , Jordan Cates
    • , E. Matt Charles
    • , Kevin Chatham-Stephens
    • , Nora Chea
    • , Howard Chiou
    • , Demian Christiansen
    • , Victoria Chu
    • , Sara Cody
    • , Max Cohen
    • , Erin E. Conners
    • , Aaron T. Curns
    • , Vishal Dasari
    • , Patrick Dawson
    • , Traci DeSalvo
    • , George Diaz
    • , Matthew Donahue
    • , Suzanne Donovan
    • , Lindsey M. Duca
    • , Keith Erickson
    • , Mathew D. Esona
    • , Suzanne Evans
    • , Jeremy Falk
    • , Leora R. Feldstein
    • , Martin Fenstersheib
    • , Marc Fischer
    • , Rebecca Fisher
    • , Chelsea Foo
    • , Marielle J. Fricchione
    • , Oren Friedman
    • , Alicia Fry
    • , Romeo R. Galang
    • , Melissa M. Garcia
    • , Susan I. Gerber
    • , Graham Gerrard
    • , Isaac Ghinai
    • , Prabhu Gounder
    • , Jonathan Grein
    • , Cheri Grigg
    • , Jeffrey D. Gunzenhauser
    • , Gary I. Gutkin
    • , Meredith Haddix
    • , Aron J. Hall
    • , George S. Han
    • , Jennifer Harcourt
    • , Kathleen Harriman
    • , Thomas Haupt
    • , Amber K. Haynes
    • , Michelle Holshue
    • , Cora Hoover
    • , Jennifer C. Hunter
    • , Max W. Jacobs
    • , Claire Jarashow
    • , Kiran Joshi
    • , Talar Kamali
    • , Shifaq Kamili
    • , Lindsay Kim
    • , Moon Kim
    • , Jan King
    • , Hannah L. Kirking
    • , Amanda Kita-Yarbro
    • , Rachel Klos
    • , Miwako Kobayashi
    • , Anna Kocharian
    • , Kenneth K. Komatsu
    • , Ram Koppaka
    • , Jennifer E. Layden
    • , Yan Li
    • , Scott Lindquist
    • , Stephen Lindstrom
    • , Ruth Link-Gelles
    • , Joana Lively
    • , Michelle Livingston
    • , Kelly Lo
    • , Jennifer Lo
    • , Xiaoyan Lu
    • , Brian Lynch
    • , Larry Madoff
    • , Lakshmi Malapati
    • , Gregory Marks
    • , Mariel Marlow
    • , Glenn E. Mathisen
    • , Nancy McClung
    • , Olivia McGovern
    • , Tristan D. McPherson
    • , Mitali Mehta
    • , Audrey Meier
    • , Lynn Mello
    • , Sung-sil Moon
    • , Margie Morgan
    • , Ruth N. Moro
    • , Janna’ Murray
    • , Rekha Murthy
    • , Shannon Novosad
    • , Sara E. Oliver
    • , Jennifer O’Shea
    • , Massimo Pacilli
    • , Clinton R. Paden
    • , Mark A. Pallansch
    • , Manisha Patel
    • , Sajan Patel
    • , Isabel Pedraza
    • , Satish K. Pillai
    • , Talia Pindyck
    • , Ian Pray
    • , Krista Queen
    • , Nichole Quick
    • , Heather Reese
    • , Roshan Reporter
    • , Brian Rha
    • , Heather Rhodes
    • , Susan Robinson
    • , Philip Robinson
    • , Melissa A. Rolfes
    • , Janell A. Routh
    • , Rachel Rubin
    • , Sarah L. Rudman
    • , Senthilkumar K. Sakthivel
    • , Sarah Scott
    • , Christopher Shepherd
    • , Varun Shetty
    • , Ethan A. Smith
    • , Shanon Smith
    • , Bryan Stierman
    • , William Stoecker
    • , Rebecca Sunenshine
    • , Regina Sy-Santos
    • , Azaibi Tamin
    • , Ying Tao
    • , Dawn Terashita
    • , Natalie J. Thornburg
    • , Suxiang Tong
    • , Elizabeth Traub
    • , Ahmet Tural
    • , Anna Uehara
    • , Timothy M. Uyeki
    • , Grace Vahey
    • , Jennifer R. Verani
    • , Elsa Villarino
    • , Megan Wallace
    • , Lijuan Wang
    • , John T. Watson
    • , Matthew Westercamp
    • , Brett Whitaker
    • , Sarah Wilkerson
    • , Rebecca C. Woodruff
    • , Jonathan M. Wortham
    • , Tiffany Wu
    • , Amy Xie
    • , Anna Yousaf
    • , Matthew Zahn
    •  & Jing Zhang
  • Letter | | Open Access

    Analysis of large genomic datasets, including gnomAD, reveals that partial LRRK2 loss of function is not strongly associated with diseases, serving as an example of how human genetics can be leveraged for target validation in drug discovery.

    • Nicola Whiffin
    • , Irina M. Armean
    • , Aaron Kleinman
    • , Jamie L. Marshall
    • , Eric V. Minikel
    • , Julia K. Goodrich
    • , Nicholas M. Quaife
    • , Joanne B. Cole
    • , Qingbo Wang
    • , Konrad J. Karczewski
    • , Beryl B. Cummings
    • , Laurent Francioli
    • , Kristen Laricchia
    • , Anna Guan
    • , Babak Alipanahi
    • , Peter Morrison
    • , Marco A. S. Baptista
    • , Kalpana M. Merchant
    • , Jessica Alföldi
    • , Irina M. Armean
    • , Eric Banks
    • , Louis Bergelson
    • , Kristian Cibulskis
    • , Ryan L. Collins
    • , Kristen M. Connolly
    • , Miguel Covarrubias
    • , Beryl Cummings
    • , Mark J. Daly
    • , Stacey Donnelly
    • , Yossi Farjoun
    • , Steven Ferriera
    • , Laurent Francioli
    • , Stacey Gabriel
    • , Laura D. Gauthier
    • , Jeff Gentry
    • , Namrata Gupta
    • , Thibault Jeandet
    • , Diane Kaplan
    • , Konrad J. Karczewski
    • , Kristen M. Laricchia
    • , Christopher Llanwarne
    • , Eric V. Minikel
    • , Ruchi Munshi
    • , Benjamin M. Neale
    • , Sam Novod
    • , Anne H. O’Donnell-Luria
    • , Nikelle Petrillo
    • , Timothy Poterba
    • , David Roazen
    • , Valentin Ruano-Rubio
    • , Andrea Saltzman
    • , Kaitlin E. Samocha
    • , Molly Schleicher
    • , Cotton Seed
    • , Matthew Solomonson
    • , Jose Soto
    • , Grace Tiao
    • , Kathleen Tibbetts
    • , Charlotte Tolonen
    • , Christopher Vittal
    • , Gordon Wade
    • , Arcturus Wang
    • , Qingbo Wang
    • , James S. Ware
    • , Nicholas A. Watts
    • , Ben Weisburd
    • , Nicola Whiffin
    • , Carlos A. Aguilar-Salinas
    • , Tariq Ahmad
    • , Christine M. Albert
    • , Diego Ardissino
    • , Gil Atzmon
    • , John Barnard
    • , Laurent Beaugerie
    • , Emelia J. Benjamin
    • , Michael Boehnke
    • , Lori L. Bonnycastle
    • , Erwin P. Bottinger
    • , Donald W. Bowden
    • , Matthew J. Bown
    • , John C. Chambers
    • , Juliana C. Chan
    • , Daniel Chasman
    • , Judy Cho
    • , Mina K. Chung
    • , Bruce Cohen
    • , Adolfo Correa
    • , Dana Dabelea
    • , Mark J. Daly
    • , Dawood Darbar
    • , Ravindranath Duggirala
    • , Josée Dupuis
    • , Patrick T. Ellinor
    • , Roberto Elosua
    • , Jeanette Erdmann
    • , Tõnu Esko
    • , Martti Färkkilä
    • , Jose Florez
    • , Andre Franke
    • , Gad Getz
    • , Benjamin Glaser
    • , Stephen J. Glatt
    • , David Goldstein
    • , Clicerio Gonzalez
    • , Leif Groop
    • , Christopher Haiman
    • , Craig Hanis
    • , Matthew Harms
    • , Mikko Hiltunen
    • , Matti M. Holi
    • , Christina M. Hultman
    • , Mikko Kallela
    • , Jaakko Kaprio
    • , Sekar Kathiresan
    • , Bong-Jo Kim
    • , Young Jin Kim
    • , George Kirov
    • , Jaspal Kooner
    • , Seppo Koskinen
    • , Harlan M. Krumholz
    • , Subra Kugathasan
    • , Soo Heon Kwak
    • , Markku Laakso
    • , Terho Lehtimäki
    • , Ruth J. F. Loos
    • , Steven A. Lubitz
    • , Ronald C. W. Ma
    • , Daniel G. MacArthur
    • , Jaume Marrugat
    • , Kari M. Mattila
    • , Steven McCarroll
    • , Mark I. McCarthy
    • , Dermot McGovern
    • , Ruth McPherson
    • , James B. Meigs
    • , Olle Melander
    • , Andres Metspalu
    • , Benjamin M. Neale
    • , Peter M. Nilsson
    • , Michael C. O’Donovan
    • , Dost Ongur
    • , Lorena Orozco
    • , Michael J. Owen
    • , Colin N. A. Palmer
    • , Aarno Palotie
    • , Kyong Soo Park
    • , Carlos Pato
    • , Ann E. Pulver
    • , Nazneen Rahman
    • , Anne M. Remes
    • , John D. Riou
    • , Samuli Ripatti
    • , Dan M. Roden
    • , Danish Saleheen
    • , Veikko Salomaa
    • , Nilesh J. Samani
    • , Jeremiah Scharf
    • , Heribert Schunkert
    • , Moore B. Shoemaker
    • , Pamela Sklar
    • , Hilkka Soininen
    • , Harry Sokol
    • , Tim Spector
    • , Patrick F. Sullivan
    • , Jaana Suvisaari
    • , E. Shyong Tai
    • , Yik Ying Teo
    • , Tuomi Tiinamaija
    • , Ming Tsuang
    • , Dan Turner
    • , Teresa Tusie-Luna
    • , Erkki Vartiainen
    • , James S. Ware
    • , Hugh Watkins
    • , Rinse K. Weersma
    • , Maija Wessman
    • , James G. Wilson
    • , Ramnik J. Xavier
    • , James S. Ware
    • , Aki S. Havulinna
    • , Bozenna Iliadou
    • , Jung-Jin Lee
    • , Girish N. Nadkarni
    • , Cole Whiteman
    • , Michelle Agee
    • , Adam Auton
    • , Robert K. Bell
    • , Katarzyna Bryc
    • , Sarah L. Elson
    • , Pierre Fontanillas
    • , Nicholas A. Furlotte
    • , Barry Hicks
    • , David A. Hinds
    • , Karen E. Huber
    • , Ethan M. Jewett
    • , Yunxuan Jiang
    • , Keng-Han Lin
    • , Nadia K. Litterman
    • , Matthew H. McIntyre
    • , Kimberly F. McManus
    • , Joanna L. Mountain
    • , Elizabeth S. Noblin
    • , Carrie A. M. Northover
    • , Steven J. Pitts
    • , G. David Poznik
    • , J. Fah Sathirapongsasuti
    • , Janie F. Shelton
    • , Suyash Shringarpure
    • , Chao Tian
    • , Joyce Y. Tung
    • , Vladimir Vacic
    • , Xin Wang
    • , Catherine H. Wilson
    • , Mark Daly
    • , Tõnu Esko
    • , Christina Hultman
    • , Ruth J. F. Loos
    • , Lili Milani
    • , Aarno Palotie
    • , Carlos Pato
    • , Michele Pato
    • , Danish Saleheen
    • , Patrick F. Sullivan
    • , Jessica Alföldi
    • , Paul Cannon
    •  & Daniel G. MacArthur

    Special:

  • Letter |

    Results from the phase IIa COMBAT trial combining CXCR4 and PD-1 inhibition in patients with metastatic cancer show encouraging clinical responses in association with enhanced antitumor immune activation.

    • Bruno Bockorny
    • , Valerya Semenisty
    • , Teresa Macarulla
    • , Erkut Borazanci
    • , Brian M. Wolpin
    • , Salomon M. Stemmer
    • , Talia Golan
    • , Ravit Geva
    • , Mitesh J. Borad
    • , Katrina S. Pedersen
    • , Joon Oh Park
    • , Robert A. Ramirez
    • , David G. Abad
    • , Jaime Feliu
    • , Andres Muñoz
    • , Mariano Ponz-Sarvise
    • , Amnon Peled
    • , Tzipora M. Lustig
    • , Osnat Bohana-Kashtan
    • , Stephen M. Shaw
    • , Ella Sorani
    • , Marya Chaney
    • , Shaul Kadosh
    • , Abi Vainstein Haras
    • , Daniel D. Von Hoff
    •  & Manuel Hidalgo
  • Letter |

    By using data from electrocardiograms, a deep learning algorithm outperforms traditional risk scores in predicting death over the course of the next year and identifies at-risk individuals with seemingly normal electrocardiograms.

    • Sushravya Raghunath
    • , Alvaro E. Ulloa Cerna
    • , Linyuan Jing
    • , David P. vanMaanen
    • , Joshua Stough
    • , Dustin N. Hartzel
    • , Joseph B. Leader
    • , H. Lester Kirchner
    • , Martin C. Stumpe
    • , Ashraf Hafez
    • , Arun Nemani
    • , Tanner Carbonati
    • , Kipp W. Johnson
    • , Katelyn Young
    • , Christopher W. Good
    • , John M. Pfeifer
    • , Aalpen A. Patel
    • , Brian P. Delisle
    • , Amro Alsaid
    • , Dominik Beer
    • , Christopher M. Haggerty
    •  & Brandon K. Fornwalt

Articles

  • Article |

    In individuals diagnosed with age-related macular degeneration in one eye, a deep learning model can predict progression to the ‘wet’, sight-threatening form of the disease in the second eye within a 6-month time frame.

    • Jason Yim
    • , Reena Chopra
    • , Terry Spitz
    • , Jim Winkens
    • , Annette Obika
    • , Christopher Kelly
    • , Harry Askham
    • , Marko Lukic
    • , Josef Huemer
    • , Katrin Fasler
    • , Gabriella Moraes
    • , Clemens Meyer
    • , Marc Wilson
    • , Jonathan Dixon
    • , Cian Hughes
    • , Geraint Rees
    • , Peng T. Khaw
    • , Alan Karthikesalingam
    • , Dominic King
    • , Demis Hassabis
    • , Mustafa Suleyman
    • , Trevor Back
    • , Joseph R. Ledsam
    • , Pearse A. Keane
    •  & Jeffrey De Fauw
  • Article |

    A deep learning system able to identify the most common skin conditions may help clinicians in making more accurate diagnoses in routine clinical practice

    • Yuan Liu
    • , Ayush Jain
    • , Clara Eng
    • , David H. Way
    • , Kang Lee
    • , Peggy Bui
    • , Kimberly Kanada
    • , Guilherme de Oliveira Marinho
    • , Jessica Gallegos
    • , Sara Gabriele
    • , Vishakha Gupta
    • , Nalini Singh
    • , Vivek Natarajan
    • , Rainer Hofmann-Wellenhof
    • , Greg S. Corrado
    • , Lily H. Peng
    • , Dale R. Webster
    • , Dennis Ai
    • , Susan J. Huang
    • , Yun Liu
    • , R. Carter Dunn
    •  & David Coz
  • Article |

    A pooled genetic, transcriptomic and immunopathologic analysis of over 500 tumors from patients with advanced renal cell cancer suggests that response to PD-1 blockade depends on both CD8+ T cell infiltration and enrichment of tumor-intrinsic somatic alterations.

    • David A. Braun
    • , Yue Hou
    • , Ziad Bakouny
    • , Miriam Ficial
    • , Miriam Sant’ Angelo
    • , Juliet Forman
    • , Petra Ross-Macdonald
    • , Ashton C. Berger
    • , Opeyemi A. Jegede
    • , Liudmilla Elagina
    • , John Steinharter
    • , Maxine Sun
    • , Megan Wind-Rotolo
    • , Jean-Christophe Pignon
    • , Andrew D. Cherniack
    • , Lee Lichtenstein
    • , Donna Neuberg
    • , Paul Catalano
    • , Gordon J. Freeman
    • , Arlene H. Sharpe
    • , David F. McDermott
    • , Eliezer M. Van Allen
    • , Sabina Signoretti
    • , Catherine J. Wu
    • , Sachet A. Shukla
    •  & Toni K. Choueiri
  • Article |

    Local microbiome composition influences treatment efficacy of chemotherapy in colon cancer via modulation of tolerogenic versus immunogenic ileal intestinal epithelial cell death, which in turn influences follicular helper T cell priming.

    • Maria Paula Roberti
    • , Satoru Yonekura
    • , Connie P. M. Duong
    • , Marion Picard
    • , Gladys Ferrere
    • , Maryam Tidjani Alou
    • , Conrad Rauber
    • , Valerio Iebba
    • , Christian H. K. Lehmann
    • , Lukas Amon
    • , Diana Dudziak
    • , Lisa Derosa
    • , Bertrand Routy
    • , Caroline Flament
    • , Corentin Richard
    • , Romain Daillère
    • , Aurélie Fluckiger
    • , Isabelle Van Seuningen
    • , Mathias Chamaillard
    • , Audrey Vincent
    • , Stephanie Kourula
    • , Paule Opolon
    • , Pierre Ly
    • , Eugénie Pizzato
    • , Sonia Becharef
    • , Juliette Paillet
    • , Christophe Klein
    • , Florence Marliot
    • , Filippo Pietrantonio
    • , Stéphane Benoist
    • , Jean-Yves Scoazec
    • , Peggy Dartigues
    • , Antoine Hollebecque
    • , David Malka
    • , Franck Pagès
    • , Jérôme Galon
    • , Ivo Gomperts Boneca
    • , Patricia Lepage
    • , Bernard Ryffel
    • , Didier Raoult
    • , Alexander Eggermont
    • , Tom Vanden Berghe
    • , François Ghiringhelli
    • , Peter Vandenabeele
    • , Guido Kroemer
    •  & Laurence Zitvogel
  • Article | | Open Access

    An HIV vaccine that elicits both antibodies and cellular immune responses confers long-lasting protection against viral challenge in nonhuman primates.

    • Prabhu S. Arunachalam
    • , Tysheena P. Charles
    • , Vineet Joag
    • , Venkata S. Bollimpelli
    • , Madeleine K. D. Scott
    • , Florian Wimmers
    • , Samantha L. Burton
    • , Celia C. Labranche
    • , Caroline Petitdemange
    • , Sailaja Gangadhara
    • , Tiffany M. Styles
    • , Clare F. Quarnstrom
    • , Korey A. Walter
    • , Thomas J. Ketas
    • , Traci Legere
    • , Pradeep Babu Jagadeesh Reddy
    • , Sudhir Pai Kasturi
    • , Anthony Tsai
    • , Bertrand Z. Yeung
    • , Shakti Gupta
    • , Mark Tomai
    • , John Vasilakos
    • , George M. Shaw
    • , Chil-Yong Kang
    • , John P. Moore
    • , Shankar Subramaniam
    • , Purvesh Khatri
    • , David Montefiori
    • , Pamela A. Kozlowski
    • , Cynthia A. Derdeyn
    • , Eric Hunter
    • , David Masopust
    • , Rama R. Amara
    •  & Bali Pulendran
  • Article | | Open Access

    Spatiotemporal characterization of microbial diversity and antibiotic resistance in a tertiary-care hospital reveals broad distribution and persistence of antibiotic-resistant organisms that could cause opportunistic infections in a healthcare setting.

    • Kern Rei Chng
    • , Chenhao Li
    • , Denis Bertrand
    • , Amanda Hui Qi Ng
    • , Junmei Samantha Kwah
    • , Hwee Meng Low
    • , Chengxuan Tong
    • , Maanasa Natrajan
    • , Michael Hongjie Zhang
    • , Licheng Xu
    • , Karrie Kwan Ki Ko
    • , Eliza Xin Pei Ho
    • , Tamar V. Av-Shalom
    • , Jeanette Woon Pei Teo
    • , Chiea Chuen Khor
    • , David Danko
    • , Daniela Bezdan
    • , Ebrahim Afshinnekoo
    • , Sofia Ahsanuddin
    • , Chandrima Bhattacharya
    • , Daniel J. Butler
    • , Kern Rei Chng
    • , Francesca De Filippis
    • , Jochen Hecht
    • , Andre Kahles
    • , Mikhail Karasikov
    • , Nikos C. Kyrpides
    • , Marcus H. Y. Leung
    • , Dmitry Meleshko
    • , Harun Mustafa
    • , Beth Mutai
    • , Russell Y. Neches
    • , Amanda Ng
    • , Marina Nieto-Caballero
    • , Olga Nikolayeva
    • , Tatyana Nikolayeva
    • , Eileen Png
    • , Jorge L. Sanchez
    • , Heba Shaaban
    • , Maria A. Sierra
    • , Xinzhao Tong
    • , Ben Young
    • , Josue Alicea
    • , Malay Bhattacharyya
    • , Ran Blekhman
    • , Eduardo Castro-Nallar
    • , Ana M. Cañas
    • , Aspassia D. Chatziefthimiou
    • , Robert W. Crawford
    • , Youping Deng
    • , Christelle Desnues
    • , Emmanuel Dias-Neto
    • , Daisy Donnellan
    • , Marius Dybwad
    • , Eran Elhaik
    • , Danilo Ercolini
    • , Alina Frolova
    • , Alexandra B. Graf
    • , David C. Green
    • , Iman Hajirasouliha
    • , Mark Hernandez
    • , Gregorio Iraola
    • , Soojin Jang
    • , Angela Jones
    • , Frank J. Kelly
    • , Kaymisha Knights
    • , Paweł P. Łabaj
    • , Patrick K. H. Lee
    • , Levy Shawn
    • , Per Ljungdahl
    • , Abigail Lyons
    • , Gabriella Mason-Buck
    • , Ken McGrath
    • , Emmanuel F. Mongodin
    • , Milton Ozorio Moraes
    • , Niranjan Nagarajan
    • , Houtan Noushmehr
    • , Manuela Oliveira
    • , Stephan Ossowski
    • , Olayinka O. Osuolale
    • , Orhan Özcan
    • , David Paez-Espino
    • , Nicolas Rascovan
    • , Hugues Richard
    • , Gunnar Rätsch
    • , Lynn M. Schriml
    • , Torsten Semmler
    • , Osman U. Sezerman
    • , Leming Shi
    • , Le Huu Song
    • , Haruo Suzuki
    • , Denise Syndercombe Court
    • , Dominique Thomas
    • , Scott W. Tighe
    • , Klas I. Udekwu
    • , Juan A. Ugalde
    • , Brandon Valentine
    • , Dimitar I. Vassilev
    • , Elena Vayndorf
    • , Thirumalaisamy P. Velavan
    • , María M. Zambrano
    • , Jifeng Zhu
    • , Sibo Zhu
    • , Christopher E. Mason
    • , Swaine L. Chen
    • , Christopher E. Mason
    • , Oon Tek Ng
    • , Kalisvar Marimuthu
    • , Brenda Ang
    •  & Niranjan Nagarajan
  • Article |

    An iPSC-based three-dimensional model of the human blood–brain barrier reveals that NFAT and APOE dysregulation in pericyte-like mural cells contributes to cerebral amyloid angiopathy and can potentially be targeted to treat Alzheimer’s disease.

    • Joel W. Blanchard
    • , Michael Bula
    • , Jose Davila-Velderrain
    • , Leyla Anne Akay
    • , Lena Zhu
    • , Alexander Frank
    • , Matheus B. Victor
    • , Julia Maeve Bonner
    • , Hansruedi Mathys
    • , Yuan-Ta Lin
    • , Tak Ko
    • , David A. Bennett
    • , Hugh P. Cam
    • , Manolis Kellis
    •  & Li-Huei Tsai
  • Article |

    The PREDICT 1 trial shows large inter-individual variations in postprandial metabolic responses to standardized meals in over 1,000 participants, demonstrating potential for development of personalized nutrition strategies.

    • Sarah E. Berry
    • , Ana M. Valdes
    • , David A. Drew
    • , Francesco Asnicar
    • , Mohsen Mazidi
    • , Jonathan Wolf
    • , Joan Capdevila
    • , George Hadjigeorgiou
    • , Richard Davies
    • , Haya Al Khatib
    • , Christopher Bonnett
    • , Sajaysurya Ganesh
    • , Elco Bakker
    • , Deborah Hart
    • , Massimo Mangino
    • , Jordi Merino
    • , Inbar Linenberg
    • , Patrick Wyatt
    • , Jose M. Ordovas
    • , Christopher D. Gardner
    • , Linda M. Delahanty
    • , Andrew T. Chan
    • , Nicola Segata
    • , Paul W. Franks
    •  & Tim D. Spector

Analysis

  • Analysis |

    A meta-analysis comparing primary efficacy outcomes of phase 2 and phase 3 randomized controlled trials in rheumatoid arthritis and psoriatic arthritis shows that phase 2 studies consistently overestimate the effect sizes anticipated in subsequent phase 3 trials.

    • Andreas Kerschbaumer
    • , Josef S. Smolen
    • , Harald Herkner
    • , Tijen Stefanova
    • , Eva Chwala
    •  & Daniel Aletaha

Amendments & Corrections