Volume 26 Issue 1, January 2020

Volume 26 Issue 1

Temperatures that deviate from long-term local norms affect human health and are projected to become more frequent as the global climate changes. In this issue, Parks et al. report an association between anomalously warm temperatures and deaths from intentional and unintentional injuries, with increases in deaths from drownings, transport, assault and suicide. The cover art is an illustrated portrayal of the association between rising temperatures and increased injury mortality, and how big data has made such insights possible.

See Parks et al.

Image credit: Amy Kate Wolfe. Cover design: Erin Dewalt

Editorial

  • Editorial |

    Large-scale multi-modal information on patients’ health is ever increasing, providing an opportunity to use big data for taking individualized medicine to a global scale.

News

News Feature

Turning Points

  • Turning Points |

    Xiling Shen is the Hawkins Family Associate Professor of Biomedical Engineering and director of the Woo Center for Big Data and Precision Health at Duke University. He is a National Science Foundation early-career awardee, chair of the National Cancer Institute’s Patient-Derived Models of Cancer consortium and an Israeli faculty fellow.

    • Xiling Shen

World View

Comment

Research Highlights

News & Views

Review Articles

Letters

  • Letter |

    Analysis of a mass cytometry dataset for different human solid tumors coupled with murine reverse translational experiments suggests that targeting CD73 could enhance the efficacy of checkpoint inhibitor therapy in glioblastoma.

    • Sangeeta Goswami
    • , Thomas Walle
    • , Andrew E. Cornish
    • , Sreyashi Basu
    • , Swetha Anandhan
    • , Irina Fernandez
    • , Luis Vence
    • , Jorge Blando
    • , Hao Zhao
    • , Shalini Singh Yadav
    • , Martina Ott
    • , Ling Y. Kong
    • , Amy B. Heimberger
    • , John de Groot
    • , Boris Sepesi
    • , Michael Overman
    • , Scott Kopetz
    • , James P. Allison
    • , Dana Pe’er
    •  & Padmanee Sharma
  • Letter |

    Results from an expansion cohort of the PROFILE 1001 trial describe the anti-tumor activity of crizotinib in people with non-small-cell lung cancer harboring a MET exon 14 alteration.

    • Alexander Drilon
    • , Jeffrey W. Clark
    • , Jared Weiss
    • , Sai-Hong Ignatius Ou
    • , D. Ross Camidge
    • , Benjamin J. Solomon
    • , Gregory A. Otterson
    • , Liza C. Villaruz
    • , Gregory J. Riely
    • , Rebecca S. Heist
    • , Mark M. Awad
    • , Geoffrey I. Shapiro
    • , Miyako Satouchi
    • , Toyoaki Hida
    • , Hidetoshi Hayashi
    • , Danielle A. Murphy
    • , Sherry C. Wang
    • , Sherry Li
    • , Tiziana Usari
    • , Keith D. Wilner
    •  & Paul K. Paik
  • Letter |

    A prospective, multicenter, case–control clinical trial evaluates the potential of artificial intelligence for providing accurate bedside diagnosis of patients with brain tumors.

    • Todd C. Hollon
    • , Balaji Pandian
    • , Arjun R. Adapa
    • , Esteban Urias
    • , Akshay V. Save
    • , Siri Sahib S. Khalsa
    • , Daniel G. Eichberg
    • , Randy S. D’Amico
    • , Zia U. Farooq
    • , Spencer Lewis
    • , Petros D. Petridis
    • , Tamara Marie
    • , Ashish H. Shah
    • , Hugh J. L. Garton
    • , Cormac O. Maher
    • , Jason A. Heth
    • , Erin L. McKean
    • , Stephen E. Sullivan
    • , Shawn L. Hervey-Jumper
    • , Parag G. Patil
    • , B. Gregory Thompson
    • , Oren Sagher
    • , Guy M. McKhann II
    • , Ricardo J. Komotar
    • , Michael E. Ivan
    • , Matija Snuderl
    • , Marc L. Otten
    • , Timothy D. Johnson
    • , Michael B. Sisti
    • , Jeffrey N. Bruce
    • , Karin M. Muraszko
    • , Jay Trautman
    • , Christian W. Freudiger
    • , Peter Canoll
    • , Honglak Lee
    • , Sandra Camelo-Piragua
    •  & Daniel A. Orringer
  • Letter |

    Expansion of pathogenic Candida species coupled with bacterial dysbiosis in the gut precedes Candida bloodstream infections in hematopoietic cell transplant recipients.

    • Bing Zhai
    • , Mihaela Ola
    • , Thierry Rolling
    • , Nicholas L. Tosini
    • , Sari Joshowitz
    • , Eric R. Littmann
    • , Luigi A. Amoretti
    • , Emily Fontana
    • , Roberta J. Wright
    • , Edwin Miranda
    • , Charlotte A. Veelken
    • , Sejal M. Morjaria
    • , Jonathan U. Peled
    • , Marcel R. M. van den Brink
    • , N. Esther Babady
    • , Geraldine Butler
    • , Ying Taur
    •  & Tobias M. Hohl
  • Letter |

    Leveraging the availability of nationwide electronic health records from over 500,000 pregnancies in Israel, a machine-learning approach offers an alternative means of predicting gestational diabetes at high accuracy in the early stages of pregnancy.

    • Nitzan Shalom Artzi
    • , Smadar Shilo
    • , Eran Hadar
    • , Hagai Rossman
    • , Shiri Barbash-Hazan
    • , Avi Ben-Haroush
    • , Ran D. Balicer
    • , Becca Feldman
    • , Arnon Wiznitzer
    •  & Eran Segal
  • Letter |

    A retrospective analysis of existing computed tomography scans shows the feasibility of an automated process for evaluating osteoporotic fracture risk that could be used as an initial screening tool when FRAX inputs are unavailable.

    • Noa Dagan
    • , Eldad Elnekave
    • , Noam Barda
    • , Orna Bregman-Amitai
    • , Amir Bar
    • , Mila Orlovsky
    • , Eitan Bachmat
    •  & Ran D. Balicer
  • Letter |

    Longitudinal multiomics profiling of a cohort of healthy people reveals distinct aging patterns—termed ageotypes—in different individuals.

    • Sara Ahadi
    • , Wenyu Zhou
    • , Sophia Miryam Schüssler-Fiorenza Rose
    • , M. Reza Sailani
    • , Kévin Contrepois
    • , Monika Avina
    • , Melanie Ashland
    • , Anne Brunet
    •  & Michael Snyder

Articles

  • Article |

    Cross-sectional analysis of data from the Adolescent Brain Cognitive Development Study shows that children from families with low income are at increased risk of cognitive impairment associated with high lead-exposure risk when compared with children from families with high income.

    • Andrew T. Marshall
    • , Samantha Betts
    • , Eric C. Kan
    • , Rob McConnell
    • , Bruce P. Lanphear
    •  & Elizabeth R. Sowell
  • Article |

    Integrated use of an animal model, a biobank for common diseases and a rare Mendelian disease leads to the discovery of a new syndrome and its pathological mechanism.

    • Gokhan Unlu
    • , Xinzi Qi
    • , Eric R. Gamazon
    • , David B. Melville
    • , Nisha Patel
    • , Amy R. Rushing
    • , Mais Hashem
    • , Abdullah Al-Faifi
    • , Rui Chen
    • , Bingshan Li
    • , Nancy J. Cox
    • , Fowzan S. Alkuraya
    •  & Ela W. Knapik
  • Article |

    Comprising data from over 18,000 people, a new atlas of drug–metabolite associations for 87 commonly prescribed drugs and 150 metabolites assessed by proton nuclear magnetic resonance provides a web-based tool to aid research on drug efficacy, safety and repurposing.

    • Jun Liu
    • , Lies Lahousse
    • , Michel G. Nivard
    • , Mariska Bot
    • , Lianmin Chen
    • , Jan Bert van Klinken
    • , Carisha S. Thesing
    • , Marian Beekman
    • , Erik Ben van den Akker
    • , Roderick C. Slieker
    • , Eveline Waterham
    • , Carla J. H. van der Kallen
    • , Irene de Boer
    • , Ruifang Li-Gao
    • , Dina Vojinovic
    • , Najaf Amin
    • , Djawad Radjabzadeh
    • , Robert Kraaij
    • , Louise J. M. Alferink
    • , Sarwa Darwish Murad
    • , André G. Uitterlinden
    • , Gonneke Willemsen
    • , Rene Pool
    • , Yuri Milaneschi
    • , Diana van Heemst
    • , H. Eka D. Suchiman
    • , Femke Rutters
    • , Petra J. M. Elders
    • , Joline W. J. Beulens
    • , Amber A. W. A. van der Heijden
    • , Marleen M. J. van Greevenbroek
    • , Ilja C. W. Arts
    • , Gerrit L. J. Onderwater
    • , Arn M. J. M. van den Maagdenberg
    • , Dennis O. Mook-Kanamori
    • , Thomas Hankemeier
    • , Gisela M. Terwindt
    • , Coen D. A. Stehouwer
    • , Johanna M. Geleijnse
    • , Leen M. ‘t Hart
    • , P. Eline Slagboom
    • , Ko Willems van Dijk
    • , Alexandra Zhernakova
    • , Jingyuan Fu
    • , Brenda W. J. H. Penninx
    • , Dorret I. Boomsma
    • , Ayşe Demirkan
    • , Bruno H. C. Stricker
    •  & Cornelia M. van Duijn
  • Article |

    Injection of AAV–shRNA below the pial surface of the spinal cord prevents onset or ameliorates progression in a mouse model of ALS, and achieves widespread delivery to the spinal cord and brain motor centers in adult pigs and non-human primates.

    • Mariana Bravo-Hernandez
    • , Takahiro Tadokoro
    • , Michael R. Navarro
    • , Oleksandr Platoshyn
    • , Yoshiomi Kobayashi
    • , Silvia Marsala
    • , Atsushi Miyanohara
    • , Stefan Juhas
    • , Jana Juhasova
    • , Helena Skalnikova
    • , Zoltan Tomori
    • , Ivo Vanicky
    • , Hana Studenovska
    • , Vladimir Proks
    • , PeiXi Chen
    • , Noe Govea-Perez
    • , Dara Ditsworth
    • , Joseph D. Ciacci
    • , Shang Gao
    • , Wenlian Zhu
    • , Eric T. Ahrens
    • , Shawn P. Driscoll
    • , Thomas D. Glenn
    • , Melissa McAlonis-Downes
    • , Sandrine Da Cruz
    • , Samuel L. Pfaff
    • , Brian K. Kaspar
    • , Don W. Cleveland
    •  & Martin Marsala
  • Article |

    Single-nucleus RNA sequencing in a mouse model of Aβ accumulation and postmortem brain tissue from people with Alzheimer’s disease reveals substantial species-specific differences in transcriptional signatures, but both point to the contribution of glia and the importance of TREM2.

    • Yingyue Zhou
    • , Wilbur M. Song
    • , Prabhakar S. Andhey
    • , Amanda Swain
    • , Tyler Levy
    • , Kelly R. Miller
    • , Pietro L. Poliani
    • , Manuela Cominelli
    • , Shikha Grover
    • , Susan Gilfillan
    • , Marina Cella
    • , Tyler K. Ulland
    • , Konstantin Zaitsev
    • , Akinori Miyashita
    • , Takeshi Ikeuchi
    • , Makoto Sainouchi
    • , Akiyoshi Kakita
    • , David A. Bennett
    • , Julie A. Schneider
    • , Michael R. Nichols
    • , Sean A. Beausoleil
    • , Jason D. Ulrich
    • , David M. Holtzman
    • , Maxim N. Artyomov
    •  & Marco Colonna
  • Article |

    Genetic analysis of paternal sperm from families with a child affected by autism reveals that the recurrent risk for transmitting disease-associated de novo mutations to future offspring is near 0% for most couples but is substantially higher for a small fraction of couples.

    • Martin W. Breuss
    • , Danny Antaki
    • , Renee D. George
    • , Morgan Kleiber
    • , Kiely N. James
    • , Laurel L. Ball
    • , Oanh Hong
    • , Ileena Mitra
    • , Xiaoxu Yang
    • , Sara A. Wirth
    • , Jing Gu
    • , Camila A. B. Garcia
    • , Madhusudan Gujral
    • , William M. Brandler
    • , Damir Musaev
    • , An Nguyen
    • , Jennifer McEvoy-Venneri
    • , Renatta Knox
    • , Evan Sticca
    • , Martha Cristina Cancino Botello
    • , Javiera Uribe Fenner
    • , Maria Cárcel Pérez
    • , Maria Arranz
    • , Andrea B. Moffitt
    • , Zihua Wang
    • , Amaia Hervás
    • , Orrin Devinsky
    • , Melissa Gymrek
    • , Jonathan Sebat
    •  & Joseph G. Gleeson