Volume 25 Issue 9, September 2019

Volume 25 Issue 9

Neuroprostheses with sensory feedback

Conventional leg prostheses do not convey sensory information about motion or interaction with the ground, to above-knee amputees, limiting their ability to recover confident prosthetic-assisted walking capacity. In this issue, Raspopovic et al report the development of a neuroprosthestic leg equipped with foot sensors of motion and ground touching that improves walking speed, confidence in walking, and reduces mental and physical fatigue associated with movement in two transfemoral amputees.

See: Raspopovic et al

Image credit: Stanisa Raspopovic and Giacomo Valle (concept), Vlado Peric (art). Cover design: Erin Dewalt

Editorial

  • Editorial |

    As the clinical potential of RNA therapeutics begins to be unveiled, expanding the range of tissue types that can be targeted for delivery of these drugs is now the main hurdle to overcome.

News Feature

Turning Points

  • Turning Points |

    Jie Qiao is a reproductive physician and biologist who is President and Chief Physician of Peking University Third Hospital. She is also Director of the National Clinical Research Center on Obstetrics & Gynecology and a member of the Chinese Academy of Engineering. Additionally, Professor Qiao is President of China Women Doctors Association and Chair for the Reproductive Medical Society of Chinese Medical Doctor Association.

    • Jie Qiao
  • Turning Points |

    Eliezer Van Allen is an assistant professor at Harvard Medical School, medical oncologist at Dana-Farber Cancer Institute and associate member of the Broad Institute of MIT and Harvard.

    • Eliezer M. Van Allen
  • Turning Points |

    Serena Nik-Zainal is a CRUK Advanced Clinician Scientist and Honorary Consultant in Clinical Genetics. Her clinical work involves rare genetic disorders, and her research focuses on cancer genomics at the University of Cambridge, UK.

    • Serena Nik-Zainal

Research Highlights

News & Views

Perspectives

  • Perspective |

    In this Perspective, the authors present a framework, context and guidelines for accelerating the translation of machine-learning-based interventions in health care.

    • Jenna Wiens
    • , Suchi Saria
    • , Mark Sendak
    • , Marzyeh Ghassemi
    • , Vincent X. Liu
    • , Finale Doshi-Velez
    • , Kenneth Jung
    • , Katherine Heller
    • , David Kale
    • , Mohammed Saeed
    • , Pilar N. Ossorio
    • , Sonoo Thadaney-Israni
    •  & Anna Goldenberg

Review Articles

Letters

  • Letter |

    A new prosthetic leg that can transmit sensory signals via implanted electrodes is shown to restore meaningful sensory feedback that improves walking performance and lowers phantom limb pain during use in two human lower-limb amputees.

    • Francesco Maria Petrini
    • , Marko Bumbasirevic
    • , Giacomo Valle
    • , Vladimir Ilic
    • , Pavle Mijović
    • , Paul Čvančara
    • , Federica Barberi
    • , Natalija Katic
    • , Dario Bortolotti
    • , David Andreu
    • , Knut Lechler
    • , Aleksandar Lesic
    • , Sanja Mazic
    • , Bogdan Mijović
    • , David Guiraud
    • , Thomas Stieglitz
    • , Asgeir Alexandersson
    • , Silvestro Micera
    •  & Stanisa Raspopovic
  • Letter |

    Genetic predispositions and lifestyle factors can interact to either confer protection against, or elevate risk for, development of clinical dementia in a prospective cohort of over 6,000 individuals from the population-based Rotterdam Study.

    • Silvan Licher
    • , Shahzad Ahmad
    • , Hata Karamujić-Čomić
    • , Trudy Voortman
    • , Maarten J. G. Leening
    • , M. Arfan Ikram
    •  & M. Kamran Ikram
  • Letter |

    Mass antibiotic administration to preschool children in Nigerien communities alters the relative abundances of 35 bacterial species in the gut microbiome, including enteric pathogens, but also increases expression of macrolide resistance genes.

    • T. Doan
    • , A. Hinterwirth
    • , L. Worden
    • , A. M. Arzika
    • , R. Maliki
    • , A. Abdou
    • , S. Kane
    • , L. Zhong
    • , S. L. Cummings
    • , S. Sakar
    • , C. Chen
    • , C. Cook
    • , E. Lebas
    • , E. D. Chow
    • , I. Nachamkin
    • , T. C. Porco
    • , J. D. Keenan
    •  & T. M. Lietman
  • Letter |

    A new compound that inhibits HIV capsid assembly and nuclear transport functions offers potential as a long-acting antiretroviral.

    • Stephen R. Yant
    • , Andrew Mulato
    • , Derek Hansen
    • , Winston C. Tse
    • , Anita Niedziela-Majka
    • , Jennifer R. Zhang
    • , George J. Stepan
    • , Debi Jin
    • , Melanie H. Wong
    • , Jill M. Perreira
    • , Eric Singer
    • , Giuseppe A. Papalia
    • , Eric Y. Hu
    • , Jim Zheng
    • , Bing Lu
    • , Scott D. Schroeder
    • , Kevin Chou
    • , Shekeba Ahmadyar
    • , Albert Liclican
    • , Helen Yu
    • , Nikolai Novikov
    • , Eric Paoli
    • , Daniel Gonik
    • , Renee R. Ram
    • , Magdeleine Hung
    • , William M. McDougall
    • , Abraham L. Brass
    • , Wesley I. Sundquist
    • , Tomas Cihlar
    •  & John O. Link
  • Letter |

    Analysis of the UK Biobank reveals new genetic loci associated with estimated visceral adipose tissue (VAT) mass, and suggests that VAT is potentially an independent risk factor for various cardiovascular and metabolic diseases, such as hypertension and type 2 diabetes.

    • Torgny Karlsson
    • , Mathias Rask-Andersen
    • , Gang Pan
    • , Julia Höglund
    • , Claes Wadelius
    • , Weronica E. Ek
    •  & Åsa Johansson
  • Letter |

    In an early-phase lentiviral gene therapy trial, gene-corrected autologous hematopoietic stem cells show sustained engraftment and phenotypic correction in non-conditioned patients with Fanconi anemia.

    • Paula Río
    • , Susana Navarro
    • , Wei Wang
    • , Rebeca Sánchez-Domínguez
    • , Roser M. Pujol
    • , José C. Segovia
    • , Massimo Bogliolo
    • , Eva Merino
    • , Ning Wu
    • , Rocío Salgado
    • , María L. Lamana
    • , Rosa M. Yañez
    • , José A. Casado
    • , Yari Giménez
    • , Francisco J. Román-Rodríguez
    • , Lara Álvarez
    • , Omaira Alberquilla
    • , Anna Raimbault
    • , Guillermo Guenechea
    • , M. Luz Lozano
    • , Laura Cerrato
    • , Miriam Hernando
    • , Eva Gálvez
    • , Raquel Hladun
    • , Irina Giralt
    • , Jordi Barquinero
    • , Anne Galy
    • , Nagore García de Andoín
    • , Ricardo López
    • , Albert Catalá
    • , Jonathan D. Schwartz
    • , Jordi Surrallés
    • , Jean Soulier
    • , Manfred Schmidt
    • , Cristina Díaz de Heredia
    • , Julián Sevilla
    •  & Juan A. Bueren
  • Letter |

    An analysis of T cell specificities sufficient to sustain a neutralizing anti-drug antibody response offers a potential approach for enhancing the clinical efficacy of a therapeutic humanized antibody.

    • Antonino Cassotta
    • , Vincent Mikol
    • , Thomas Bertrand
    • , Stéphanie Pouzieux
    • , Josiane Le Parc
    • , Paul Ferrari
    • , Jacques Dumas
    • , Michael Auer
    • , Florian Deisenhammer
    • , Matteo Gastaldi
    • , Diego Franciotta
    • , Chiara Silacci-Fregni
    • , Blanca Fernandez Rodriguez
    • , Isabella Giacchetto-Sasselli
    • , Mathilde Foglierini
    • , David Jarrossay
    • , Roger Geiger
    • , Federica Sallusto
    • , Antonio Lanzavecchia
    •  & Luca Piccoli
  • Letter |

    New low-affinity anti-CD19 CAR T cells exhibit peripheral expansion and persistence without inducing severe cytokine-response syndrome in pediatric patients with relapsed or refractory B cell acute lymphoblastic leukemia.

    • Sara Ghorashian
    • , Anne Marijn Kramer
    • , Shimobi Onuoha
    • , Gary Wright
    • , Jack Bartram
    • , Rachel Richardson
    • , Sarah J. Albon
    • , Joan Casanovas-Company
    • , Fernanda Castro
    • , Bilyana Popova
    • , Krystle Villanueva
    • , Jenny Yeung
    • , Winston Vetharoy
    • , Aleks Guvenel
    • , Patrycja A. Wawrzyniecka
    • , Leila Mekkaoui
    • , Gordon Weng-Kit Cheung
    • , Danielle Pinner
    • , Jan Chu
    • , Giovanna Lucchini
    • , Juliana Silva
    • , Oana Ciocarlie
    • , Arina Lazareva
    • , Sarah Inglott
    • , Kimberly C. Gilmour
    • , Gulrukh Ahsan
    • , Mathieu Ferrari
    • , Somayya Manzoor
    • , Kim Champion
    • , Tony Brooks
    • , Andre Lopes
    • , Allan Hackshaw
    • , Farzin Farzaneh
    • , Robert Chiesa
    • , Kanchan Rao
    • , Denise Bonney
    • , Sujith Samarasinghe
    • , Nicholas Goulden
    • , Ajay Vora
    • , Paul Veys
    • , Rachael Hough
    • , Robert Wynn
    • , Martin A. Pule
    •  & Persis J. Amrolia
  • Letter |

    Direct prospective comparison of circulating tumor DNA and tissue biopsy sequencing shows the superiority of liquid biopsies for capturing clinically relevant alterations mediating resistance to targeted therapies in cancer patients.

    • Aparna R. Parikh
    • , Ignaty Leshchiner
    • , Liudmila Elagina
    • , Lipika Goyal
    • , Chaya Levovitz
    • , Giulia Siravegna
    • , Dimitri Livitz
    • , Kahn Rhrissorrakrai
    • , Elizabeth E. Martin
    • , Emily E. Van Seventer
    • , Megan Hanna
    • , Kara Slowik
    • , Filippo Utro
    • , Christopher J. Pinto
    • , Alicia Wong
    • , Brian P. Danysh
    • , Ferran Fece de la Cruz
    • , Isobel J. Fetter
    • , Brandon Nadres
    • , Heather A. Shahzade
    • , Jill N. Allen
    • , Lawrence S. Blaszkowsky
    • , Jeffrey W. Clark
    • , Bruce Giantonio
    • , Janet E. Murphy
    • , Ryan D. Nipp
    • , Eric Roeland
    • , David P. Ryan
    • , Colin D. Weekes
    • , Eunice L. Kwak
    • , Jason E. Faris
    • , Jennifer Y. Wo
    • , François Aguet
    • , Ipsita Dey-Guha
    • , Mehlika Hazar-Rethinam
    • , Dora Dias-Santagata
    • , David T. Ting
    • , Andrew X. Zhu
    • , Theodore S. Hong
    • , Todd R. Golub
    • , A. John Iafrate
    • , Viktor A. Adalsteinsson
    • , Alberto Bardelli
    • , Laxmi Parida
    • , Dejan Juric
    • , Gad Getz
    •  & Ryan B. Corcoran
  • Letter |

    A subset of patients treated with selective TRK inhibitors (including the newly approved larotrectinib) develop off-target resistance mediated by genomic acquisition of MAPK pathway-activating alterations, and may benefit from combined targeted therapy.

    • Emiliano Cocco
    • , Alison M. Schram
    • , Amanda Kulick
    • , Sandra Misale
    • , Helen H. Won
    • , Rona Yaeger
    • , Pedram Razavi
    • , Ryan Ptashkin
    • , Jaclyn F. Hechtman
    • , Eneda Toska
    • , James Cownie
    • , Romel Somwar
    • , Sophie Shifman
    • , Marissa Mattar
    • , S. Duygu Selçuklu
    • , Aliaksandra Samoila
    • , Sean Guzman
    • , Brian B. Tuch
    • , Kevin Ebata
    • , Elisa de Stanchina
    • , Rebecca J. Nagy
    • , Richard B. Lanman
    • , Brian Houck-Loomis
    • , Juber A. Patel
    • , Michael F. Berger
    • , Marc Ladanyi
    • , David M. Hyman
    • , Alexander Drilon
    •  & Maurizio Scaltriti

Articles

  • Article |

    Stress reduces the effects of various cancer therapies, such as chemotherapy and immunotherapy, in mice; this is mediated, at least partially, through Tsc22d3 upregulation in tumor-infiltrating dendritic cells, which leads to immunosuppression.

    • Heng Yang
    • , Lin Xia
    • , Jian Chen
    • , Shuqing Zhang
    • , Vincent Martin
    • , Qingqing Li
    • , Shangqing Lin
    • , Jinfeng Chen
    • , Joseph Calmette
    • , Min Lu
    • , Lingyi Fu
    • , Jie Yang
    • , Zhizhong Pan
    • , Kuai Yu
    • , Jingjing He
    • , Eric Morand
    • , Géraldine Schlecht-Louf
    • , Roman Krzysiek
    • , Laurence Zitvogel
    • , Boxi Kang
    • , Zeming Zhang
    • , Andrew Leader
    • , Penghui Zhou
    • , Laurence Lanfumey
    • , Minxin Shi
    • , Guido Kroemer
    •  & Yuting Ma

Resources

  • Resource |

    A comprehensive biobank of bacterial isolates with longitudinal and multi-omics characterization will advance understanding of the diversity and functions of human gut bacteria.

    • M. Poyet
    • , M. Groussin
    • , S. M. Gibbons
    • , J. Avila-Pacheco
    • , X. Jiang
    • , S. M. Kearney
    • , A. R. Perrotta
    • , B. Berdy
    • , S. Zhao
    • , T. D. Lieberman
    • , P. K. Swanson
    • , M. Smith
    • , S. Roesemann
    • , J. E. Alexander
    • , S. A. Rich
    • , J. Livny
    • , H. Vlamakis
    • , C. Clish
    • , K. Bullock
    • , A. Deik
    • , J. Scott
    • , K. A. Pierce
    • , R. J. Xavier
    •  & E. J. Alm

Technical Reports

Amendments & Corrections

  • Publisher Correction | | Open Access

    • Natalia V. Bhattacharjee
    • , Lauren E. Schaeffer
    • , Laurie B. Marczak
    • , Jennifer M. Ross
    • , Scott J. Swartz
    • , James Albright
    • , William M. Gardner
    • , Chloe Shields
    • , Amber Sligar
    • , Megan F. Schipp
    • , Brandon V. Pickering
    • , Nathaniel J. Henry
    • , Kimberly B. Johnson
    • , Celia Louie
    • , Michael A. Cork
    • , Krista M. Steuben
    • , Alice Lazzar-Atwood
    • , Dan Lu
    • , Damaris K. Kinyoki
    • , Aaron Osgood-Zimmerman
    • , Lucas Earl
    • , Jonathan F. Mosser
    • , Aniruddha Deshpande
    • , Roy Burstein
    • , Lauren P. Woyczynski
    • , Katherine F. Wilson
    • , John D. VanderHeide
    • , Kirsten E. Wiens
    • , Robert C. Reiner Jr
    • , Ellen G. Piwoz
    • , Rahul Rawat
    • , Benn Sartorius
    • , Nicole Davis Weaver
    • , Molly R. Nixon
    • , David L. Smith
    • , Nicholas J. Kassebaum
    • , Emmanuela Gakidou
    • , Stephen S. Lim
    • , Ali H. Mokdad
    • , Christopher J. L. Murray
    • , Laura Dwyer-Lindgren
    •  & Simon I. Hay