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Volume 25 Issue 5, May 2019

Volume 25 Issue 5

Modeling injury in the developing human brain

Premature infants often undergo repeated episodes of hypoxia and can develop a condition called encephalopathy of prematurity with long-term neurodevelopmental impairments. In this issue, Paşca et al. use human pluripotent stem cells to develop a three-dimensional brain-organoid-based model of early brain injury and investigate the cellular effects of oxygen deprivation on human cortical development. The cover illustrates efforts to generate in vitro cellular models of the developing human brain to study and prevent injury.

Image credit: Andy Pots. Cover design: Erin Dewalt

Editorial

  • Editorial |

    Immune interventions capable of preventing or eradicating HIV infection have yet to achieve broad success in humans. Renewed vigor in the clinical trial arena may bring us closer to that goal.

News Feature

Turning Points

  • Turning Points |

    Ami Bhatt is a physician-scientist and assistant professor of medicine and genetics at Stanford University. Her research deploys next-generation sequencing to explore host–microbiome interactions, including those in cancer.

    • Ami S. Bhatt
  • Turning Points |

    Max Nieuwdorp is an internist, endocrinologist and vascular medicine specialist at Amsterdam University Medical Centers. He chairs the Diabetes Center there and is chief of the Department and Laboratory of Vascular Medicine.

    • Max Nieuwdorp

Research Highlights

News & Views

  • News & Views |

    Three innovative precision medicine studies show the utility of evidence beyond that from tumor DNA sequencing to guide therapy in patients with cancer.

    • Christophe Le Tourneau
    • Edith Borcoman
    • Maud Kamal
  • News & Views |

    Human survivors of Ebola virus disease are more likely than uninfected controls to develop memory loss, uveitis, and other abnormal conditions, and Ebola virus remains in semen much longer than previously thought.

    • Daniel S. Chertow

Perspectives

  • Perspective |

    The use and promotion of probiotics is widespread, but debatable in many cases. Prospective large-scale randomized studies that assess their effectiveness in promoting health and curing disease and take into account personalized responses of discrete human subpopulations will help clarify specific indications in which probiotics may be safe and beneficial.

    • Jotham Suez
    • Niv Zmora
    • Eran Elinav

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