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Intracellular traffic of the HIV-1 transactivator protein Tat appears essential for pathogenesis, and interdiction by immunization-induced antibodies to Tat should prevent AIDS.
Inhibition of nitric oxide synthesis by 7-nitroindazole prevents destruction of dopamine neurons and parkinsonian symptoms in baboons treated with MPTP (page 1017–1021).
Insight into the molecular mechanism of rapamycin's immunosuppressive effects provides the basis for a novel approach to regulating therapeutic gene expression (pages 1028-1032).
